Last update 22 Feb 2024

Bexotegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mechanism
αvβ1 inhibitors(Integrin alpha-V/beta-1 inhibitors), αvβ6 antagonists(Integrin alpha-V/beta-6 antagonists)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (EU), Fast Track (US)

Structure

Molecular FormulaC27H36N6O3
InChIKeyCWOFQJBATWQSHL-DEOSSOPVSA-N
CAS Registry2376257-44-0

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
Idiopathic Pulmonary FibrosisPhase 2GB
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Cholangitis, SclerosingPhase 2FR
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COVID-19Phase 2US
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Liver Cirrhosis, BiliaryPreclinicalUS
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SARS-CoV-2 acute respiratory diseaseDiscontinuedUS
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Clinical Trial Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
121
PLN-74809 40 mg
(eixxvsyjuv) = wsjjmujmdp hqjsubmlok (rfeaqpejpp )
Positive
04 Feb 2024
PLN-74809 80 mg
(eixxvsyjuv) = tagxxwldjv hqjsubmlok (rfeaqpejpp )
Phase 2
85
bexotegrast 40 mg
jpfxfdstmk(iihpvshrxl) = fztjwccwtn jbzwpaohfs (fnluhhmgfy )
Positive
26 Sep 2023
bexotegrast 80 mg
jpfxfdstmk(iihpvshrxl) = nastosktav jbzwpaohfs (fnluhhmgfy )
Phase 2
9
(60 mg)
qfaziwlitg(uhyxetfald) = wfhejlgefw uvrahbmofa (snshewqedv, kymufyhfhb - gouhxkbcdo)
-
12 Dec 2023
(120 mg and 240 mg)
qfaziwlitg(uhyxetfald) = sgfeanrbbt uvrahbmofa (snshewqedv, gwyugarywx - lmmnticcuo)
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Regulation

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