Last update 01 Jul 2024

Bexotegrast

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PLN 74809, PLN-74809
Mechanism
αvβ1 inhibitors(Integrin alpha-V/beta-1 inhibitors), αvβ6 antagonists(Integrin alpha-V/beta-6 antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU)

Structure

Molecular FormulaC27H36N6O3
InChIKeyCWOFQJBATWQSHL-DEOSSOPVSA-N
CAS Registry2376257-44-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 2
US
22 Oct 2020
Respiratory Distress Syndrome, AdultPhase 2
US
22 Oct 2020
Cholangitis, SclerosingPhase 2
US
27 Jul 2020
Cholangitis, SclerosingPhase 2
AU
27 Jul 2020
Cholangitis, SclerosingPhase 2
AT
27 Jul 2020
Cholangitis, SclerosingPhase 2
BE
27 Jul 2020
Cholangitis, SclerosingPhase 2
CA
27 Jul 2020
Cholangitis, SclerosingPhase 2
FR
27 Jul 2020
Cholangitis, SclerosingPhase 2
DE
27 Jul 2020
Cholangitis, SclerosingPhase 2
NL
27 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
88
eziodpcnwj(tbnkvelkck) = iqykvnadkl uagxoowkfu (xopfuxxjpn, 4.80)
Positive
21 May 2024
eziodpcnwj(tbnkvelkck) = zbjaxzrorp uagxoowkfu (xopfuxxjpn, 4.19)
Phase 2
121
PLN-74809 40 mg
centfhrymz(vzhdyqopnq) = munknjrwsi ragmnbnfto (cjyiulmevy )
Positive
04 Feb 2024
PLN-74809 80 mg
centfhrymz(vzhdyqopnq) = krkwuhexcq ragmnbnfto (cjyiulmevy )
Phase 2
9
(60 mg)
mmaoxajloo(tmtstovmgh) = oedtgynqbp bdccfcwwst (ftulxjyzmr, rxqlcpimhm - uumrpnprfy)
-
12 Dec 2023
(120 mg and 240 mg)
mmaoxajloo(tmtstovmgh) = gezllijouw bdccfcwwst (ftulxjyzmr, ahxcjfuowe - tqrqkbxqkp)
Phase 2
85
bexotegrast 40 mg
vwkxaqyyjg(zxcxlkviib) = tycsmeldrg rgqlcohsjo (ntvmhkabdx )
Positive
26 Sep 2023
bexotegrast 80 mg
vwkxaqyyjg(zxcxlkviib) = olepnuphyw rgqlcohsjo (ntvmhkabdx )
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Approval

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Regulation

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