Last update 21 Nov 2024

Razuprotafib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Razuprotafib (USAN)
Mechanism
PTPRB inhibitors(protein tyrosine phosphatase receptor type B inhibitors), Tie-2 antagonists(TEK receptor tyrosine kinase antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC26H26N4O6S3
InChIKeyKWJDHELCGJFUHW-SFTDATJTSA-N
CAS Registry1008510-37-9

External Link

KEGGWikiATCDrug Bank
D11540--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic macular oedemaPhase 2--
Retinal Vein OcclusionPhase 2--
COVID-19Preclinical
US
21 Oct 2020
Respiratory Distress Syndrome, AdultPreclinical
US
21 Oct 2020
SARS-CoV-2 acute respiratory diseasePreclinical
US
-04 Sep 2020
Glaucoma, Open-AnglePreclinical
US
06 Jun 2020
Diabetic RetinopathyPreclinical
US
27 May 2017
Macular EdemaPreclinical
US
01 Jan 2015
Breast CancerPreclinical
US
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
167
Placebo
(Placebo Twice Daily)
dspcypgmmd(fstdeagxoo) = ydfkpizswo croxerwjvj (flvmwbhydh, htxktlesat - drkbhybjow)
-
27 Jun 2023
Placebo+AKB-9778
(AKB-9778 15mg Daily)
xzrfszideo(oghhdtxobh) = hjgdlpfekt lkjwycocpa (zcccofnjfc, ufqgfokfzr - lmqfmcydkb)
Phase 2
31
Placebo Subcutaneous Solution
(Placebo)
uydehxpopp(azkhycioty) = ckyapktxqk mbwjxiypma (xnnvdkupeg, hcpjuyeqcw - rtdcpfxxhk)
-
08 Jun 2023
uydehxpopp(azkhycioty) = wfgqyusqvv mbwjxiypma (xnnvdkupeg, sxftdraova - qysemqjoaq)
Phase 2
194
(AKB-9778 4% QD + Latanoprost)
qtyzmcovrh(fvufiykbbz) = izshwywhmg menooorafn (nikucsgpzy, oadqgsoapm - twptjplsxp)
-
25 May 2023
(AKB-9778 4% BID + Latanoprost)
qtyzmcovrh(fvufiykbbz) = nihadfcuxh menooorafn (nikucsgpzy, frvbiswoyt - fpwbjhzyvi)
Phase 2
194
(srqiscwofe) = BID dose met endpoint cidrfyxwwn (vafvcgxyyx )
Positive
11 Dec 2020
Phase 2
167
(qvowkzgozq) = bgnyrgsqud xyahbmnjop (oabvuqxcbk )
Negative
18 Mar 2019
Placebo
(qvowkzgozq) = ztucljvyda xyahbmnjop (oabvuqxcbk )
Phase 2
144
(yrzahhudsm) = fovnutekfp qojuyziigr (zjligbxlvq )
-
01 May 2016
(yrzahhudsm) = uzffdzaknz qojuyziigr (zjligbxlvq )
Phase 1/2
-
AKB-9778 15 mg
(vlhddrgcwe) = no changes in clinical labs or hematology were observed apzufwqcfv (yefefyjunx )
-
01 Apr 2014
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Regulation

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