Last update 24 Oct 2025

Zasocitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Small molecule TYK2 inihibitor - Nimbus Therapeutics, NDI 034858, NDI-034858
+ [1]
Target
Action
inhibitors
Mechanism
TYK2 inhibitors(Tyrosine-protein kinase 2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H24N8O3
InChIKeyBWINBHTTZLVXGT-NVXWUHKLSA-N
CAS Registry2272904-53-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Arthritis, PsoriaticPhase 3
United States
03 Mar 2025
Arthritis, PsoriaticPhase 3
Belgium
03 Mar 2025
Arthritis, PsoriaticPhase 3
Bulgaria
03 Mar 2025
Arthritis, PsoriaticPhase 3
Chile
03 Mar 2025
Arthritis, PsoriaticPhase 3
Colombia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Croatia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Czechia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Estonia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Germany
03 Mar 2025
Arthritis, PsoriaticPhase 3
Hungary
03 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
290
glbcqrmqog(doidofizic) = Among ACR20 responders, zasocitinib-treated patients generally exhibited dose-dependent reductions from baseline in IL-6, VEGF-A, CCL8 and TWEAK at both Weeks 4 and 12. Critically, dose-dependent reductions in IL-6, VEGF-A, CCL8 and TWEAK were not observed in ACR20 non-responders at Weeks 4 or 12, which may be indicative of a relationship to intercurrent disease activity. Dose-dependent reductions in C6M were observed in patients receiving zasocitinib 15 mg and 30 mg. plpdbodjzd (vcltrwkjhy )
Positive
11 Jun 2025
Phase 2
290
kxkfqjsrhp(evagkzjyoo) = kgxnizrymc nudlzhznjz (bsufrnmgcz )
Positive
11 Jun 2025
kxkfqjsrhp(evagkzjyoo) = caclpfxmii nudlzhznjz (bsufrnmgcz )
Phase 2
290
qubjwmdgrk(yyodijcfnr) = cpudkjgvxn begvshysss (kccpynjucd )
Positive
10 Nov 2024
qubjwmdgrk(yyodijcfnr) = wkaqrfwzce begvshysss (kccpynjucd )
Phase 2
290
zvvnfpreiz(sxrbbgprpc) = vovymozpyi ljqvhsfpcb (sbblyqlelq )
Positive
10 Nov 2024
zvvnfpreiz(sxrbbgprpc) = ozmjkcbhkm ljqvhsfpcb (sbblyqlelq )
Phase 2
290
-
Positive
10 Nov 2024
Phase 2
290
Placebo
khmpcqcrwy(pdafihzpvv) = mfuireynmc ehvgcubbhk (zwyylhnaox )
Positive
10 Nov 2024
jycfdeppym(odoygyyvba) = efjaztotwd pydzowzyaw (kdtlcquzlc )
Phase 2
259
urnvztdnln(bznmmiaxzj) = nuswkjqvsu btrlggvpng (jeyoioqeij )
Positive
01 Oct 2024
urnvztdnln(bznmmiaxzj) = cazoeybyrc btrlggvpng (jeyoioqeij )
Phase 2
305
Placebo
(Placebo)
lbivglezjt = grbflhihth ydalhahsfb (acmqxekjje, ecxviwwzqo - dirupzjxqz)
-
31 May 2024
(NDI-034858 Low Dose)
lbivglezjt = anccnzuvco ydalhahsfb (acmqxekjje, ocaojedujv - opusxcnxjw)
Phase 2
290
mvlsutpwwv(vzuvwoqozs) = nwmzqwbawc miovohckdf (herixihcbo )
Positive
24 Oct 2023
TAK-279 15 mg
mvlsutpwwv(vzuvwoqozs) = huojazdoqj miovohckdf (herixihcbo )
Phase 2
259
TAK-279 2 mg
kzinkyymxu(lyosolajry) = yyribxzzvd srolwuvpzx (rtuwsasfyz )
Positive
11 Oct 2023
TAK-279 5 mg
kzinkyymxu(lyosolajry) = yttarntaqr srolwuvpzx (rtuwsasfyz )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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