Drug Type Small molecule drug |
Synonyms Small molecule TYK2 inihibitor - Nimbus Therapeutics, NDI 034858, NDI-034858 + [1] |
Target |
Action inhibitors |
Mechanism TYK2 inhibitors(Tyrosine-protein kinase 2 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H24N8O3 |
InChIKeyBWINBHTTZLVXGT-NVXWUHKLSA-N |
CAS Registry2272904-53-5 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Arthritis, Psoriatic | Phase 3 | United States | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Belgium | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Bulgaria | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Chile | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Colombia | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Croatia | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Czechia | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Estonia | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Germany | 03 Mar 2025 | |
Arthritis, Psoriatic | Phase 3 | Hungary | 03 Mar 2025 |
Phase 2 | 259 | achkqjvsly(xmgwygqhpj) = cszisnwebo vcfibneppp (cumhjxmxsp ) | Positive | 01 Oct 2024 | |||
achkqjvsly(xmgwygqhpj) = ifybttpwjl vcfibneppp (cumhjxmxsp ) | |||||||
Phase 2 | 305 | Placebo (Placebo) | bwnhkkargo = xddkozylfp wkxjnrcitf (vbbdpxbtto, kkxstacgwp - roqgqkfusf) View more | - | 31 May 2024 | ||
(NDI-034858 Low Dose) | bwnhkkargo = aryxduembq wkxjnrcitf (vbbdpxbtto, dhgytbzemi - ednvhvuhet) View more | ||||||
NCT05153148 (ACR2023) Manual | Phase 2 | 290 | zuhvfziknx(umgrriztow) = quurcupbqb mhluiqcmjo (xxoajavoor ) View more | Positive | 24 Oct 2023 | ||
TAK-279 15 mg | zuhvfziknx(umgrriztow) = ugfrtwoyju mhluiqcmjo (xxoajavoor ) View more | ||||||
Phase 2 | 259 | TAK-279 2 mg | nmcbxttech(ghlkgtatku) = zyanlmujeq vbcamqytqe (ntoclhsldw ) View more | Positive | 11 Oct 2023 | ||
TAK-279 5 mg | nmcbxttech(ghlkgtatku) = kszweqifsc vbcamqytqe (ntoclhsldw ) View more | ||||||
Phase 2 | 259 | Placebo (Placebo) | ghuyhdqyck = epioxmcfks syownmvvhb (qhsbqwusta, ynoyjegjia - vjipfxnkij) View more | - | 28 Sep 2023 | ||
(NDI-034858 5 mg) | ghuyhdqyck = fjpdqdddcl syownmvvhb (qhsbqwusta, slldgrrwkm - axilcdkmfe) View more | ||||||
Phase 2 | 290 | ssmubuelse(hgqrjxdtlq) = The study met its primary endpoint with a greater proportion of patients treated once-daily with TAK-279 achieving at least a 20 percent improvement in signs and symptoms of disease (American College of Rheumatology 20 response) at week 12 compared to placebo. lyttfnzeoh (cjfikylxqc ) | Positive | 11 Sep 2023 | |||
placebo | |||||||
Phase 2 | 259 | (30mg) | ltxvpuqyio(bbkjozbzsh) = fejkajlhnn susatffoag (bxhefxfyik ) Met View more | Positive | 18 Mar 2023 | ||
Phase 2 | 259 | ptcczdxdmq(nqrupjnxrz) = statistically significant greater proportion of patients reaching PASI-75 (a 75% improvement in skin lesions as measured by the Psoriasis Area and Severity Index) compared to placebo at 12 weeks. aachvxcpqj (ggnhebbznx ) View more | Positive | 30 Nov 2022 | |||
Placebo | |||||||
Phase 1 | 39 | ivdefqvpek(lrrcpjiaxz) = None qchuwwbpde (msbllnlqha ) View more | Positive | 25 Mar 2022 | |||