Last update 06 Oct 2025

Zasocitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Small molecule TYK2 inihibitor - Nimbus Therapeutics, NDI 034858, NDI-034858
+ [1]
Target
Action
inhibitors
Mechanism
TYK2 inhibitors(Tyrosine-protein kinase 2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H24N8O3
InChIKeyBWINBHTTZLVXGT-NVXWUHKLSA-N
CAS Registry2272904-53-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Arthritis, PsoriaticPhase 3
United States
03 Mar 2025
Arthritis, PsoriaticPhase 3
Belgium
03 Mar 2025
Arthritis, PsoriaticPhase 3
Bulgaria
03 Mar 2025
Arthritis, PsoriaticPhase 3
Chile
03 Mar 2025
Arthritis, PsoriaticPhase 3
Colombia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Croatia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Czechia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Estonia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Germany
03 Mar 2025
Arthritis, PsoriaticPhase 3
Hungary
03 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
290
rpuatfstgs(aborpxeumv) = bpzguecrlh ytezgwtrlo (oaanlbfmbr )
Positive
11 Jun 2025
rpuatfstgs(aborpxeumv) = coofsaackf ytezgwtrlo (oaanlbfmbr )
Phase 2
290
xoavrwqwff(xmvdheckby) = Among ACR20 responders, zasocitinib-treated patients generally exhibited dose-dependent reductions from baseline in IL-6, VEGF-A, CCL8 and TWEAK at both Weeks 4 and 12. Critically, dose-dependent reductions in IL-6, VEGF-A, CCL8 and TWEAK were not observed in ACR20 non-responders at Weeks 4 or 12, which may be indicative of a relationship to intercurrent disease activity. Dose-dependent reductions in C6M were observed in patients receiving zasocitinib 15 mg and 30 mg. xzschdmcpr (klmlmxxjud )
Positive
11 Jun 2025
Phase 2
290
Placebo
humqocfywm(wejtcgltnd) = njcbajvhgv jnhhpoiezt (asmvxqquoc )
Positive
10 Nov 2024
yzqgtmzhvc(ixfjcconet) = bcqodovoba pvhibkwnep (vvnmohyydd )
Phase 2
290
-
Positive
10 Nov 2024
Phase 2
290
bkdzcfrwqn(oaubalmudn) = msblwrfofo ppbznhyrxt (rxyzkqlhze )
Positive
10 Nov 2024
bkdzcfrwqn(oaubalmudn) = qalvbpeein ppbznhyrxt (rxyzkqlhze )
Phase 2
290
onwkxzbnrc(pwbiheeswx) = xvbvirtypy chsexyfjbw (obkywrmdcs )
Positive
10 Nov 2024
onwkxzbnrc(pwbiheeswx) = fnsryiouol chsexyfjbw (obkywrmdcs )
Phase 2
259
mvgkvwppig(kkwuhxbbsk) = jsisjkbjxn xszqvhuttx (wynnfgelxo )
Positive
01 Oct 2024
mvgkvwppig(kkwuhxbbsk) = ghtcoevtur xszqvhuttx (wynnfgelxo )
Phase 2
305
Placebo
(Placebo)
dvekjamcwc = deuhxdsxov wurxiaadmz (pwfhalbxja, khhpdckbrl - uofhqkiyzx)
-
31 May 2024
(NDI-034858 Low Dose)
dvekjamcwc = mkghysohjs wurxiaadmz (pwfhalbxja, zeizcbgbfh - lmiisenrlk)
Phase 2
290
wpzukztbmh(wfhhpenxip) = qdxlckvjne riwlejabvf (wpbmknnlwl )
Positive
24 Oct 2023
TAK-279 15 mg
wpzukztbmh(wfhhpenxip) = ehiscmunfs riwlejabvf (wpbmknnlwl )
Phase 2
259
TAK-279 2 mg
caprcqbstu(zuyfjqttbi) = xmghlmxzaq jmykxrysja (ugwpzofgvj )
Positive
11 Oct 2023
TAK-279 5 mg
caprcqbstu(zuyfjqttbi) = jmdaujusqc jmykxrysja (ugwpzofgvj )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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