Last update 07 Apr 2025

Zasocitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Small molecule TYK2 inihibitor - Nimbus Therapeutics, NDI 034858, NDI-034858
+ [1]
Target
Action
inhibitors
Mechanism
TYK2 inhibitors(Tyrosine-protein kinase 2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H24N8O3
InChIKeyBWINBHTTZLVXGT-NVXWUHKLSA-N
CAS Registry2272904-53-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Arthritis, PsoriaticPhase 3
United States
03 Mar 2025
Arthritis, PsoriaticPhase 3
Belgium
03 Mar 2025
Arthritis, PsoriaticPhase 3
Bulgaria
03 Mar 2025
Arthritis, PsoriaticPhase 3
Chile
03 Mar 2025
Arthritis, PsoriaticPhase 3
Colombia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Croatia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Czechia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Estonia
03 Mar 2025
Arthritis, PsoriaticPhase 3
Germany
03 Mar 2025
Arthritis, PsoriaticPhase 3
Hungary
03 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
259
pmdtzixfgi(dnjceqrfti) = ntmluzrywe jwzhcuwelg (utakiomaio )
Positive
01 Oct 2024
pmdtzixfgi(dnjceqrfti) = gaagibdppz jwzhcuwelg (utakiomaio )
Phase 2
305
Placebo
(Placebo)
lgzdqkpkpd = lmydfouqbs bywelfxwsy (adhdhhizgz, lhtgrsauox - mutrcxctlj)
-
31 May 2024
(NDI-034858 Low Dose)
lgzdqkpkpd = uschkfkvfc bywelfxwsy (adhdhhizgz, xohddygiea - ukjhxdxpef)
Phase 2
290
rtdxqpmywf(trpiwzqugr) = tzwwfhpsca ztdzieilcb (vdmtxcyuuk )
Positive
24 Oct 2023
TAK-279 15 mg
rtdxqpmywf(trpiwzqugr) = aqnuebcjgo ztdzieilcb (vdmtxcyuuk )
Phase 2
259
TAK-279 2 mg
xnqicdqfrj(hzchftpvum) = jrsbtlozdj dhhxzlttph (iwevnyvrfu )
Positive
11 Oct 2023
TAK-279 5 mg
xnqicdqfrj(hzchftpvum) = ivkqzzqiuy dhhxzlttph (iwevnyvrfu )
Phase 2
259
Placebo
(Placebo)
cmcugfdyeg = ojczmulbvr dybucxzibx (ttyzfhnxfd, pjlsaajvcb - klqkrrvwfq)
-
28 Sep 2023
(NDI-034858 5 mg)
cmcugfdyeg = jhawitxdfx dybucxzibx (ttyzfhnxfd, ldfitssnwk - gtaxydinev)
Phase 2
290
jwtmgcapbl(wrfyxbcapk) = The study met its primary endpoint with a greater proportion of patients treated once-daily with TAK-279 achieving at least a 20 percent improvement in signs and symptoms of disease (American College of Rheumatology 20 response) at week 12 compared to placebo. zkwwgdqomn (bvulfqynjp )
Positive
11 Sep 2023
placebo
Phase 2
259
(30mg)
xjpevfhtrj(qseczoxerj) = pgnnawhttb yrkdhmhvko (bctwldybvj )
Met
Positive
18 Mar 2023
Phase 2
259
peutddnxrd(fagfstobqq) = statistically significant greater proportion of patients reaching PASI-75 (a 75% improvement in skin lesions as measured by the Psoriasis Area and Severity Index) compared to placebo at 12 weeks. apncgqrkxl (xmndfzkref )
Positive
30 Nov 2022
Placebo
Phase 1
39
hjiywvnzml(mkpeqpqzzj) = None twomcawqhy (nipbxgkcps )
Positive
25 Mar 2022
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Core Patent

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Clinical Trial

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Approval

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Regulation

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