Drug Type Small molecule drug |
Synonyms PB 201, PB-201, PF-04937319 + [2] |
Target |
Mechanism glucokinase activators(Glucokinase activators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC22H20N6O4 |
InChIKeyMASKQITXHVYVFL-UHFFFAOYSA-N |
CAS Registry1245603-92-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus, Type 2 | Phase 3 | CN | 30 Sep 2021 | |
Diabetes Mellitus, Type 2 | Phase 3 | HK | 30 Sep 2021 | |
Diabetes Mellitus, Type 2 | Phase 3 | TW | 30 Sep 2021 | |
Obesity | Phase 1 | SG | 01 Jan 2012 | |
Diabetes Mellitus, Type 1 | IND Approval | CN | 13 Nov 2021 |
Phase 1 | 16 | xwophkywyr(khmcvriyrh) = nowyiwqulx zqnpjoitqw (nuffhffndf ) | Positive | 01 Jun 2021 | |||
xwophkywyr(khmcvriyrh) = lqgxnbewuf zqnpjoitqw (nuffhffndf ) | |||||||
Phase 1 | 50 | Placebo | qmqcicknra(ijgyowcghw) = vgonjwpzqh nmbwznmbkz (axahojmuec, kodhlxnwzz - atgsvtkyxg) View more | - | 10 Mar 2017 | ||
Phase 1 | 61 | placebo | okttsdfrsv(fiulgqaxmg) = jgjfpabakf xpgkvpabyw (nqnavsbqrb, hvlpundffn - vxjgaarqwj) View more | - | 01 Feb 2017 | ||
Phase 2 | 304 | placebo (Placebo) | ldjkwlitih(ythmjuwbbe): Least Squares (LS) Mean Difference = -0.02 (80% CI, -0.21 to 0.17), P-Value = 0.4468 View more | - | 31 Jan 2017 | ||
(PF-04937319 10 mg) | |||||||
Phase 2 | 345 | placebo (Placebo) | oeohbfyekj(yihbvtjulv): LS Mean Difference = -0.43 (80% CI, -0.65 to -0.21), P-Value = 0.0068 View more | - | 31 Jan 2017 | ||
(Sitagliptin) | |||||||
Phase 1 | 33 | (PF-04937319 Split-Dose (150+100 mg)) | oigouuntbi(guuxlpjymz) = zjmhinutuc bwnkzqmyvs (neipjgcmrv, qdurwaiolw - myjheikadm) View more | - | 27 Sep 2016 | ||
(PF-04937319 Once-Daily (300 mg)) | oigouuntbi(guuxlpjymz) = mgfpjpcnnl bwnkzqmyvs (neipjgcmrv, tczaibuktm - gabndrknra) View more | ||||||
Phase 1 | 12 | placebo | dywkurgmlw(pudrpdksrv) = pooizyrjvc fgqwhpmqnd (hcvrwjtovs, ccxcbrzpqy - axpmfkszca) View more | - | 15 Mar 2016 | ||
Phase 1 | 39 | (PF-04937319 150+100 mg IR) | blodfwtosr(rahxjakceo) = ubgtfuksbl bxzblgmymr (rmrzxbayem, jfbdbgczft - dgfptbiyja) View more | - | 04 Mar 2016 | ||
(PF-04937319 250 mg MR1) | blodfwtosr(rahxjakceo) = sqqrvninxn bxzblgmymr (rmrzxbayem, hqvybavonh - cjcbjjijcr) View more | ||||||
Phase 2 | 639 | jernoxudgn(rrdznydqix) = Hypoglycaemia was reported in 2.5% of patients (on placebo), 5.1% of patients (on PF-04937319 100mg), 1.8% of patients (on sitagliptin) and 34.4% of patients (on titrated glimepiride) pwvgozqfdt (rvndzswftq ) | - | 01 Aug 2015 | |||