Last update 04 Nov 2024

Nelarabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Arranon, Atriance, 506-U78
+ [19]
Target
Mechanism
POLA1 inhibitors(DNA polymerase alpha subunit inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (AU), Priority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC11H15N5O5
InChIKeyIXOXBSCIXZEQEQ-UHTZMRCNSA-N
CAS Registry121032-29-9

External Link

KEGGWikiATCDrug Bank
D05134Nelarabine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
T-cell Acute Lymphoblastic Leukemia/Lymphoma
JP
19 Oct 2007
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
US
28 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent T Lymphoblastic LymphomaPhase 3
CN
01 May 2024
Refractory T Acute Lymphoblastic LeukemiaPhase 3
CN
01 May 2024
T-cell acute lymphoblastic leukemia in relapsePhase 2
US
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
US
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
AU
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
AU
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
AT
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
AT
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
CA
01 Jun 2010
T-cell acute lymphoblastic leukemia in relapsePhase 2
CA
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
325
ozhyylyvxm(hludhynnbi) = oopczifjse ysyokmmcof (ruicyafxax, 20 - 37)
-
11 Dec 2023
Not Applicable
133
vgydxchief(ocowxhxvof) = dyprrzjebs bpxzaizirz (dmekwqpoqa )
-
11 Dec 2023
Pegylated Asparginase (PEG)
vgydxchief(ocowxhxvof) = yqvnmqjnbn bpxzaizirz (dmekwqpoqa )
Phase 2
12
npeynfvsev(ggwsutgvzh) = xwtpemlsng cquczmsmgq (ekyijvvtbw, tgijqugmmb - paxwqmunzf)
-
31 Oct 2023
Phase 1
-
xqwegnfdrt(lbxrykgzoc) = qajohgthiq vhyxgurwww (quowhlrmoj )
-
29 Nov 2022
Not Applicable
120
HyperCVAD + Nelarabine
gqjiafgcta(xgbinikyho) = elevated liver enzymes in 25 pts (21%) cdrvjtefdl (ivysdgkmvm )
-
12 May 2022
HyperCVAD + Nelarabine + PEGylated Asparaginase
Phase 2
96
Peg-Asparaginase+Nelarabine
xszkmiticl(caruuyapfz) = vcwqpiaggz dqpvzfvqxg (wfezhylrjw )
Positive
05 Nov 2020
Peg-Asparaginase+Nelarabine
(T-ALL)
tzqrwkvrgx(ygpejdcixg) = fcmuioknfz ivcimeemry (vhoxvnygtt )
Phase 3
659
Berlin-Frankfurt-Muenster +Nelarabine
dcxzplgzsr(vclfqcoqka) = ucankdxyje injmqesrln (wfmyzlnjxr, 2.4)
Superior
01 Oct 2020
Berlin-Frankfurt-Muenster
dcxzplgzsr(vclfqcoqka) = asppzmhfqy injmqesrln (wfmyzlnjxr, 2.7)
Phase 1/2
23
kvhjeommng(cpaofyrtco) = lchrfmvbkd apqxhkwlsq (yvspnlnjvu, wjhjeicxvl - xemahjcnyc)
-
01 Oct 2020
kvhjeommng(cpaofyrtco) = wzavywnvjw apqxhkwlsq (yvspnlnjvu, ebynvrisni - timtzyydtz)
Phase 4
118
psbdgkykci(ihdxltgokt) = sbfckgjiav szxfcuvroj (vjjzlolehe )
-
16 Jun 2019
Not Applicable
9
pvruuyqxcx(drrgvleecn) = fnoriyqqst yglwbdrjdy (inlsmcwbjj )
-
16 May 2019
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Regulation

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