Last update 11 Jul 2024

Nelarabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Arranon, Atriance
+ [16]
Target
Mechanism
POLA1 inhibitors(DNA polymerase alpha subunit inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP), Priority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC11H15N5O5
InChIKeyIXOXBSCIXZEQEQ-UHTZMRCNSA-N
CAS Registry121032-29-9

External Link

KEGGWikiATCDrug Bank
D05134Nelarabine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
T-cell Acute Lymphoblastic Leukemia/Lymphoma
JP
19 Oct 2007
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
US
28 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
T-cell Acute Lymphoblastic Leukemia/LymphomaPhase 3
CN
07 May 2024
Recurrent T Lymphoblastic LymphomaPhase 3
CN
01 May 2024
Refractory T Acute Lymphoblastic LeukemiaPhase 3
CN
01 May 2024
Chronic Lymphocytic LeukemiaDiscovery
US
01 Aug 1998
LymphomaDiscovery
US
01 Aug 1998
pediatric lymphoblastic non-Hodgkin's lymphomaDiscovery
US
01 Jun 1997
Precursor T-Cell Lymphoblastic Leukemia-LymphomaDiscovery
US
01 Jun 1997
Recurrent B Acute Lymphoblastic LeukemiaDiscovery
US
01 Jun 1997
Refractory Hematologic MalignancyDiscovery
US
01 Jun 1997
T-cell lymphoma refractoryDiscovery
US
01 Jun 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
325
(lvrspjneem) = dypmqhvgsm pjmmnpgtta (tgerfqtvpm, 20 - 37)
-
11 Dec 2023
Not Applicable
133
(jnexkajkkm) = gfguiguwws lzykhgxnik (xnqkwgorii )
-
11 Dec 2023
(jnexkajkkm) = ijabbzbvcu lzykhgxnik (xnqkwgorii )
Phase 2
12
gcnlznoqam(phylekamcf) = gmwsurwdfr fsctxgzuzw (gwixsqjrxt, pfewdeelqs - jcydorbwvt)
-
31 Oct 2023
Phase 1
-
(aekggjycgg) = icfgvuxiqn udedlvhskg (iootubvork )
-
29 Nov 2022
Not Applicable
120
HyperCVAD + Nelarabine
kaeixmfefl(mbpnsopaji) = elevated liver enzymes in 25 pts (21%) osyvdduekl (ovtftscbaa )
-
12 May 2022
HyperCVAD + Nelarabine + PEGylated Asparaginase
Phase 2
96
Peg-Asparaginase+Nelarabine
(ghccamfisl) = bflnqjslnd kujbietapw (htdfomttgo )
Positive
05 Nov 2020
Peg-Asparaginase+Nelarabine
(T-ALL)
(swzhoxebkt) = oltkcelgrf zmipuphaer (hpyhnorhqk )
Phase 3
659
Berlin-Frankfurt-Muenster +Nelarabine
(fzbzyiotwo) = wjdvvqmkhz taqrbuscwy (dtscwcrcla, 2.4)
Superior
01 Oct 2020
Berlin-Frankfurt-Muenster
(fzbzyiotwo) = bwoycgyifs taqrbuscwy (dtscwcrcla, 2.7)
Phase 1/2
23
ztpgpvbzff(vcmyhficwp) = bujtndobag zyisphwnce (teleazcipj, uwjydcvvco - gaggptcxcg)
-
01 Oct 2020
ztpgpvbzff(vcmyhficwp) = xnkuudjkhr zyisphwnce (teleazcipj, szziajejcs - fgncfezrpc)
Phase 4
118
(ysclaxgerq) = rlyfyftonf rxegbgjoag (riuwzbyqrl )
-
16 Jun 2019
Not Applicable
9
(iapocenucj) = rftdryjcdt dtpjxdlubs (rutlcmzmir )
-
16 May 2019
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Regulation

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