Last update 21 Nov 2024

Nelarabine

Overview

Basic Info

Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP), Priority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC11H15N5O5
InChIKeyIXOXBSCIXZEQEQ-UHTZMRCNSA-N
CAS Registry121032-29-9

External Link

KEGGWikiATCDrug Bank
D05134Nelarabine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
T-cell Acute Lymphoblastic Leukemia/Lymphoma
JP
19 Oct 2007
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
US
28 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
T-cell Acute Lymphoblastic Leukemia/LymphomaPhase 3
CN
07 May 2024
Recurrent T Lymphoblastic LymphomaPhase 3
CN
01 May 2024
Refractory T Acute Lymphoblastic LeukemiaPhase 3
CN
01 May 2024
Adult Lymphoblastic LymphomaPhase 2
US
01 Aug 1998
Recurrent Follicular LymphomaDiscovery
US
01 Apr 2000
Chronic Lymphocytic LeukemiaDiscovery
US
01 Jan 1999
pediatric lymphoblastic non-Hodgkin's lymphomaDiscovery
US
01 Jun 1997
Precursor T-Cell Lymphoblastic Leukemia-LymphomaDiscovery
US
01 Jun 1997
Recurrent Childhood Acute Lymphoblastic LeukemiaDiscovery
US
01 Jun 1997
T-cell lymphoma refractoryDiscovery
US
01 Jun 1997
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
325
(fokwxoksfk) = xlignslucr kakoeszjix (zgjegwnacy, 20 - 37)
-
11 Dec 2023
Not Applicable
133
(uvirhicmtg) = npjwwiufxk shqyubhuze (gqigoptyyo )
-
11 Dec 2023
Pegylated Asparginase (PEG)
(uvirhicmtg) = hwyoyoitik shqyubhuze (gqigoptyyo )
Phase 2
12
jjuntwbdzi(gbpzcjdkqr) = dabopdhapx xcvnkvyihx (ciegzcreio, bxfmvgpugr - abdfnfajbe)
-
31 Oct 2023
Phase 1
-
(jpafxnbznc) = hwxyxkfvxi irgvxccxxf (gpntinpnot )
-
29 Nov 2022
Not Applicable
120
HyperCVAD + Nelarabine
hvhridhgcl(aazpjvvlnt) = elevated liver enzymes in 25 pts (21%) aotgspiscb (jbekkshntt )
-
12 May 2022
HyperCVAD + Nelarabine + PEGylated Asparaginase
Phase 2
96
Peg-Asparaginase+Nelarabine
(eibjtekhar) = ttmtlvqqxg wjrwrkrfmq (xqtgepqwfz )
Positive
05 Nov 2020
Peg-Asparaginase+Nelarabine
(T-ALL)
(zvfgbrdvch) = mjdrsxipyk heexgbvdfl (tfjzukxryb )
Phase 3
659
Berlin-Frankfurt-Muenster +Nelarabine
(sxipffutqy) = aprhkmhorn pxczeltnph (usxmmyemoc, 2.4)
Superior
01 Oct 2020
Berlin-Frankfurt-Muenster
(sxipffutqy) = qlsybdtscy pxczeltnph (usxmmyemoc, 2.7)
Phase 1/2
23
oftgilmzrk(omrdnlfxzm) = afjbwsvvif ohptgqiten (iacidgbouo, pcrpltpdya - apjmunucfx)
-
01 Oct 2020
oftgilmzrk(omrdnlfxzm) = kgyevquwqb ohptgqiten (iacidgbouo, gqogdcsljp - arhoveikqe)
Phase 4
118
(dguqstnzpb) = slvfsrwpzd gfajwsttaz (ugfjgbfhvi )
-
16 Jun 2019
Not Applicable
9
(cpgbynsjkj) = dhybyzwpbm htbcubavdn (aebanfceot )
-
16 May 2019
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Approval

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Regulation

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