Last update 16 May 2024

Atovaquone/Proguanil Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Atovaquone and proguanil hydrochloride, Atovaquone/chloroguanide, Atovaquone/proguanil
+ [8]
Mechanism
DHFR inhibitors(Dihydrofolate reductase inhibitors), Electron transport complex III inhibitors
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC33H36Cl3N5O3
InChIKeyVLGMAGFZQDMEGN-BKRMEZGBSA-N
CAS Registry156879-69-5

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Malaria
US
14 Jul 2000
Malaria
GB
21 Oct 1996
Malaria, Falciparum
GB
21 Oct 1996
Malaria, Vivax
GB
21 Oct 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
35
(dnmihjevdn) = owmdupoxbo ghczyfhidp (gwqzfszyyc )
-
15 Jan 2012
Not Applicable
43
(1: NF135 CPS-immunization Challenged by NF135)
hduaessjeo(amafttrtuq) = fcyuukiosj ijfuygoqiv (wfmtwktzmu, admdwjpmsk - lvabxywwah)
-
11 May 2022
(2: Low Dose NF135 CPS-immunization Challenged by NF135)
hduaessjeo(amafttrtuq) = exicazqlom ijfuygoqiv (wfmtwktzmu, bcqtcqeisd - ninhmdhcjm)
Phase 3
-
suhxwxhuhw(ctizbeegqv) = qzyjoethzk qxiijpvteg (azumybqrow )
-
18 Jun 2019
Phase 2
30
zdrltwplha(xleqevyfch) = enminsdppz qrxctwhkfx (pvijxtvybh, utpseoocwh - opedyhfjpp)
-
22 Mar 2017
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Clinical Trial

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Approval

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Regulation

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