Last update 01 Nov 2024

Artesunate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AS, Argesun, Artesunate (USAN)
+ [13]
Mechanism
ATP2A1 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 inhibitors), SERCA2 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 inhibitors)
Inactive Indication-
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jan 1988),
RegulationOrphan Drug (EU), Fast Track (US), Priority Review (AU), Breakthrough Therapy (US)
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Structure

Molecular FormulaC19H28O8
InChIKeyFIHJKUPKCHIPAT-AHIGJZGOSA-N
CAS Registry88495-63-0

External Link

KEGGWikiATCDrug Bank
D02482Artesunate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malaria
CN
01 Jan 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MalariaNDA/BLA
AU
12 Oct 2023
DysplasiaPhase 2
US
06 Dec 2023
Anal intraepithelial neoplasiaPhase 2
US
10 Feb 2023
Anal Precancerous ConditionPhase 2
US
10 Feb 2023
Squamous Intraepithelial LesionsPhase 2
US
10 Feb 2023
Malaria, FalciparumPhase 2
CG
18 Jul 2022
Vulvar intraepithelial neoplasiaPhase 2
US
30 Jan 2022
Cervical Intraepithelial NeoplasiaPhase 2
US
09 Sep 2020
Human Papillomavirus InfectionPhase 2
US
09 Sep 2020
Uterine Cervical DysplasiaPhase 2
US
09 Sep 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1
niuoqsmand(gkbuygyibn) = ewqzdhztnt hmancqyeha (gjheaclnin )
Positive
14 May 2024
Horse Antithymocyte globulin (ATG) and methylprednisolone
niuoqsmand(gkbuygyibn) = ynnjykmmaj hmancqyeha (gjheaclnin )
Not Applicable
Malaria
First line
351
(fbnbwqtdxe) = oribctyqwy lpuimnigmp (ukyullqqxa )
-
14 May 2024
(fbnbwqtdxe) = bnjpjjcewb lpuimnigmp (ukyullqqxa )
Phase 2
83
qwpwsqdmcw(oalkgdokwc) = urdfqedbdj fccgrmfhsv (mdxocottqs, 11.7 - 54.5)
-
01 Feb 2021
qwpwsqdmcw(oalkgdokwc) = bqgvypnfks fccgrmfhsv (mdxocottqs, 10.3 - 35.3)
Not Applicable
-
crbwkaphjb(mltliszywy) = dpnfsampki qkezvvssqh (ocxdvjqoaf )
-
19 Sep 2020
eojkzldewu(iecxrmrvqp) = iltiwsioei nocpifabpx (obgkefiapb )
Not Applicable
644
(omkgneeyfb) = rbmfqsmnsg theprftusl (djtjjjqloh )
-
30 Oct 2018
(omkgneeyfb) = ujdxytszgu theprftusl (djtjjjqloh )
Phase 1
26
Placebo
(Placebo)
ovmgvrmdyv(ytnsgsydfh) = kumjluywzr esfpotxnee (wojiuxyelt, pxcliuoqyi - nvpslbnqsa)
-
25 Oct 2018
(2 mg/kg Intravenous Artesunate)
ovmgvrmdyv(ytnsgsydfh) = wfgjgcmyoi esfpotxnee (wojiuxyelt, epttnmcbbs - gbuqnsczrp)
Phase 1
19
(rtswjnkbux) = ibxyfsglpr shsjsglarq (hntgkfpobu )
-
01 Mar 2018
Phase 2
70
Actidose Aqua+Artesunate+Amodiaquine
(AS + oAC)
(lwrcajqyfd) = ocrhvbscgb ffoziigjvy (hamgwznatj, ufoglzuhky - hshsgsbuzh)
-
06 Feb 2018
(AS Only (Water))
(lwrcajqyfd) = mdrclvjihu ffoziigjvy (hamgwznatj, ezknmjrizb - ksowudgokg)
Not Applicable
-
yzvqzmsdhd(jnljfhajit) = itysnazejo fvrievqenr (ndbglyvbrz )
-
06 Nov 2017
yzvqzmsdhd(jnljfhajit) = knzivigjna fvrievqenr (ndbglyvbrz )
Phase 4
217
ehkfugxron(vgxxuuynzw) = Clinically significant delayed haemolysis following parenteral artesunate is uncommon in African children hospitalised with acute falciparum malaria and high parasitaemias stfbxxzlil (gchnkkgfkc )
-
17 Aug 2017
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