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Last update 22 Nov 2025
BC-006
Last update 22 Nov 2025
Overview
Basic Info
Drug Type Monoclonal antibody |
Synonyms ADG125, BC-006, BC006 |
Target |
Action antagonists |
Mechanism CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Sequence Code 319501096CDR2-L
Sequence Code 431762733CDR1-H
Sequence Code 432628977CDR2-H
Sequence Code 432629055CDR3-H
Sequence Code 756220516CDR1-L
Sequence Code 756220519CDR3-L
Sequence Code 756220526VH
Sequence Code 756220536VL
Sequence Code 788347768L
Sequence Code 788347770H
Related
2
Clinical Trials associated with BC-006ISRCTN11223313
A phase 1, randomized, double-blind, placebo-controlled, single-dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of a subcutaneous injection of BC-006 in adults with obesity- part 1
NCT05212896
An Exploratory Clinical Study to Evaluate the Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of BC006 Monoclonal Antibody Injection in Patients With Advanced Solid Tumors Including Giant Cell Tumor of Tendon Sheath
100 Clinical Results associated with BC-006
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100 Translational Medicine associated with BC-006
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100 Patents (Medical) associated with BC-006
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1
Literatures (Medical) associated with BC-00601 Aug 2022Food chemistryQ1 · AGRICULTURAL & FORESTRY SCIENCE
Fungal digestive enzymes promote macronutrient hydrolysis in the INFOGEST static in vitro simulation of digestion
Q1 · AGRICULTURAL & FORESTRY SCIENCE
Article
Author: Hollins, Morgan D ; Best, Caroline H ; Tinker, Kelly M ; Guice, Justin L ; Garvey, Sean M
The objective of this study was to test the hydrolytic efficacy of 6 fungal enzymes in the INFOGEST static in vitro simulation of gastrointestinal (GI) digestion. First, the INFOGEST protocol was adapted for testing of exogenous enzymes. Second, a dose-response study of 3 individual fungal proteases, a lipase, and an amylase with glucoamylase demonstrated improved dietary protein, lipid, and carbohydrate hydrolysis, respectively, from an oral nutritional supplement (ONS) under simulated gastric or GI conditions, compared to pepsin and pancreatin-based control conditions. Third, a combination of the 6 enzymes (BC-006) improved macronutrient digestion, including enhanced release of individual amino acids from ONS and mixed meal substrates. Finally, we validated digestive models of aging and proton pump inhibitor (PPI) use, and showed that BC-006 improved gastric digestion under these compromised digestive conditions. The INFOGEST static simulation is a feasible tool to rapidly screen and profile exogenous enzymes for digestive efficacy in vitro.
100 Deals associated with BC-006
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Idiopathic Pulmonary Fibrosis | Phase 1 | China | 14 Jul 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | China | 18 Sep 2021 | |
| Giant Cell Tumor of Tendon Sheath | Phase 1 | China | 18 Sep 2021 |
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