Delving into the Latest Updates on BC-006 with Synapse

Overview

Basic Info

Drug Type

Monoclonal antibody

Synonyms

Target

CSF-1R

Action

antagonists

Mechanism

CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists)

Therapeutic Areas

NeoplasmsNervous System DiseasesRespiratory Diseases+ [2]

Active Indication

Idiopathic Pulmonary FibrosisAdvanced Malignant Solid NeoplasmGiant Cell Tumor of Tendon Sheath

Inactive Indication-

Originator Organization

Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.

Active Organization

Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.

Adagene, Inc.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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Structure/Sequence

Sequence Code 756220536VL

Sequence Code 432629055CDR3-H

Sequence Code 756220526VH

Sequence Code 432628977CDR2-H

Sequence Code 431762733CDR1-H

Sequence Code 756220519CDR3-L

Sequence Code 788347768L

Sequence Code 756220516CDR1-L

Sequence Code 788347770H

Sequence Code 319501096CDR2-L

This is a first in human, open-label, exploratory phase I clinical study including dose escalation (Ia) and dose expansion (Ib) stage. It aims to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of BC006 in giant cell tumor of tendon sheath (GCTTS) and other advanced solid tumors.

Start Date26 Nov 2021

Sponsor / Collaborator

Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.

[+1]

100 Clinical Results associated with BC-006

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100 Translational Medicine associated with BC-006

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100 Patents (Medical) associated with BC-006

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1

Literatures (Medical) associated with BC-006

01 Aug 2022·Food ChemistryQ1 · AGRICULTURAL & FORESTRY SCIENCE

Fungal digestive enzymes promote macronutrient hydrolysis in the INFOGEST static in vitro simulation of digestion

Q1 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Tinker, Kelly M ; Best, Caroline H ; Hollins, Morgan D ; Garvey, Sean M ; Guice, Justin L

The objective of this study was to test the hydrolytic efficacy of 6 fungal enzymes in the INFOGEST static in vitro simulation of gastrointestinal (GI) digestion. First, the INFOGEST protocol was adapted for testing of exogenous enzymes. Second, a dose-response study of 3 individual fungal proteases, a lipase, and an amylase with glucoamylase demonstrated improved dietary protein, lipid, and carbohydrate hydrolysis, respectively, from an oral nutritional supplement (ONS) under simulated gastric or GI conditions, compared to pepsin and pancreatin-based control conditions. Third, a combination of the 6 enzymes (BC-006) improved macronutrient digestion, including enhanced release of individual amino acids from ONS and mixed meal substrates. Finally, we validated digestive models of aging and proton pump inhibitor (PPI) use, and showed that BC-006 improved gastric digestion under these compromised digestive conditions. The INFOGEST static simulation is a feasible tool to rapidly screen and profile exogenous enzymes for digestive efficacy in vitro.

100 Deals associated with BC-006

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Idiopathic Pulmonary Fibrosis	Phase 1	China	Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.	14 Jul 2022
Advanced Malignant Solid Neoplasm	Phase 1	China	Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.	18 Sep 2021
Giant Cell Tumor of Tendon Sheath	Phase 1	China	Dragon Boat Pharmaceutical (Shanghai) Co., Ltd.	18 Sep 2021

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Clinical Result

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Biosimilar

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