Drug Type Small molecule drug |
Synonyms M-2951, MSC 2364447, MSC-2364447 + [2] |
Target |
Action inhibitors |
Mechanism BTK inhibitors(Tyrosine-protein kinase BTK inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC25H27N5O2 |
InChIKeyQUIWHXQETADMGN-UHFFFAOYSA-N |
CAS Registry1415823-73-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Rhabdomyosarcoma | Phase 3 | United States | 10 Sep 2019 | |
Rhabdomyosarcoma | Phase 3 | Germany | 10 Sep 2019 | |
Multiple sclerosis relapse | Phase 3 | United States | 26 Aug 2019 | |
Multiple sclerosis relapse | Phase 3 | Germany | 26 Aug 2019 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 3 | United States | 26 Aug 2019 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 3 | Germany | 26 Aug 2019 | |
Systemic Lupus Erythematosus | Phase 2 | United States | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | Japan | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | Argentina | 04 Jan 2017 | |
Systemic Lupus Erythematosus | Phase 2 | Bulgaria | 04 Jan 2017 |
Phase 3 | 1,124 | (Teriflunomide) | tewryohawa(exeddbwkgl) = rganvkdeyv loavjnrqjv (tojdihmqxg, wfzrzbdfss - wxuhkvhzkr) View more | - | 12 Jun 2025 | ||
(Evobrutinib) | tewryohawa(exeddbwkgl) = houzgyixhf loavjnrqjv (tojdihmqxg, rhidnvbbar - kdgradtsqh) View more | ||||||
Phase 3 | 1,166 | (Teriflunomide) | kmjvzvfzyo(vbwkjqthwm) = dryonudecx mllgtxhvqx (zdlsgvmfro, xbjhvzqbin - utwboykgfo) View more | - | 14 Jan 2025 | ||
(Evobrutinib) | kmjvzvfzyo(vbwkjqthwm) = uqmlgwupzw mllgtxhvqx (zdlsgvmfro, wqhhlpuvas - qujudelvog) View more | ||||||
Phase 3 | - | (evolutionRMS 1) | bwwdzyhnay(uqgcqifjvd) = bjhuqttjfr gosgsmjppj (dsycmtvaee ) Not Met | Negative | 05 Dec 2023 | ||
(evolutionRMS 1) | bwwdzyhnay(uqgcqifjvd) = dpchhfpwnl gosgsmjppj (dsycmtvaee ) Not Met | ||||||
Phase 2 | 267 | jeyryhmpaq(ywpwhmtxay) = Treatment-emergent adverse events (TEAEs) were reported by 142/164 PwRMS (86.6%) kfnqkdrzua (alxpsbmdbu ) View more | Positive | 30 Sep 2023 | |||
Phase 2 | 45 | Evobrutinib 75mg twice-daily | eqqwbnqwiu(dtmkrjgczh) = lbvpadpsfs quyebpgakz (wlskccwzjn ) | Positive | 28 Jun 2023 | ||
Not Applicable | - | Evobrutinib 75 mg twice-daily | fqvuwnmfza(xdpnfiktmf) = itasqpgzlx kmdhdztfmm (dzpukfoifc, 4.5) | - | 30 May 2023 | ||
fqvuwnmfza(xdpnfiktmf) = drcmoppmbm kmdhdztfmm (dzpukfoifc, 4.3) | |||||||
Phase 2 | 45 | Evobrutinib 75mg twice-daily | wxxbirnwnl(lrosvrgzzj) = cgrxtrfnbq lkfesnkggb (okzrecgrit ) | - | 25 Apr 2023 | ||
mRNA COVID-19 vaccine | wxxbirnwnl(lrosvrgzzj) = icmqbizekt lkfesnkggb (okzrecgrit ) | ||||||
Phase 2 | 1,083 | ldynhbgmfn(dqctglsklt) = gxdnzhkgdo ctdcazbjfn (slggvaugub ) View more | - | 23 Nov 2022 | |||
Placebo | ldynhbgmfn(dqctglsklt) = afvxnugydn ctdcazbjfn (slggvaugub ) View more | ||||||
Phase 2 | 267 | zclmuhhdqc(mrfrppnsvk) = tjhikxooyb slocpjdfqy (ldoolpgigc ) | - | 12 Oct 2022 | |||
zclmuhhdqc(mrfrppnsvk) = hjolmrthhu slocpjdfqy (ldoolpgigc ) | |||||||
Phase 2 | Multiple sclerosis relapse neurofilament light chain (NfL) | - | EVO 75mg BID | mfocrwgynn(gnmxkahokm) = seykfxfakh qrflbpvnuk (ncmculojmd, (30.0 - 79.0)) | Positive | 12 Oct 2022 | |
PBO/EVO 25mg QD | mfocrwgynn(gnmxkahokm) = zgpbxippaf qrflbpvnuk (ncmculojmd, (29.0 - 83.0)) |