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Last update 01 Mar 2025
Anecortave Acetate
Last update 01 Mar 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Anacortave, Anecortave, Anecortave acetate (JAN/USAN) + [6] |
Target |
Mechanism VEGF inhibitors(Vascular endothelial growth factor inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC23H30O5 |
InChIKeyYUWPMEXLKGOSBF-GACAOOTBSA-N |
CAS Registry7753-60-8 |
Related
37
Clinical Trials associated with Anecortave AcetateNCT00884039
Compassionate Use of Anecortave Acetate: Clinical Protocol for the Treatment of Corticosteroid-induced Intraocular Pressure (IOP) Increases After Corneal Transplantation
NCT00788541
A Dose-Volume Study of the Safety and IOP-Lowering Efficacy of Anecortave Acetate in Patients With Open-Angle Glaucoma or Ocular Hypertension
NCT00691717
A Study of the Safety and IOP-Lowering Efficacy of Anecortave Acetate in Patients With Open-Angle Glaucoma or Ocular Hypertension
100 Clinical Results associated with Anecortave Acetate
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100 Translational Medicine associated with Anecortave Acetate
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100 Patents (Medical) associated with Anecortave Acetate
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139
Literatures (Medical) associated with Anecortave Acetate01 Dec 2024CHEMISTRY & BIODIVERSITY
Unveiling the Therapeutic Potentials of Water Hyacinth (Eichhornia crassipes (Mart.) Solms) Flower against Oxidative Stress, Inflammation and Depressive Disorders: GC‐MS/MS, In Vitro, In Vivo and In Silico Approaches
Article
Author: Shompa, Suriya Akter ; Wang, Shuanghu ; Riti, Saima Jahan ; Khan, Md. Salim ; Al Mamun, Abdullah ; Alam, Safaet ; Shao, Chuxiao ; Zeng, Chunlai ; Islam, Md. Mirazul ; Geng, Peiwu ; Kabir, Ferdousy ; Hasnat, Hasin
Abstract:
Water hyacinth (Eichhornia crassipes (Mart.) Solms) is a highly invasive aquatic weed native to the Amazonia basin, known for its rapid propagation, adaptability, and utilization in traditional medicine. The study aims to unveil the therapeutic potential of water hyacinth flowers methanolic extract (EC CME) and its four kupchan fractions (EC PESF, EC DCMSF, EC EASF, EC ASF) through diversified chemical‐pharmacological approaches. GC‐MS/MS of EC‐CME uncovered a rich tapestry of 72 phytochemical components. In vitro DPPH scavenging assay and total phenolic content determination assay deciphered promising antioxidant assays with remarkably low IC50 values of 0.353 and 0.485 μg/mL, respectively for EC‐ESF and EC‐ASF. Besides, different in vivo tests, including tail emersion, acetic acid‐induced writhing, and thiopental‐induced sleeping test of EC‐CME, yielded a remarkable 8.61±0.29 min of tail immersion time compared to the control's 2.05±0.11 min at the highest dose (600 mg/kg). The best % inhibition of writhing was recorded as 47.96 % accrued in 400 mg/kg dose, indicating robust pain‐relieving properties. The onset and duration of sleep are significantly ameliorated for EC‐CME, unveiling its antidepressant potential. Besides, molecular docking studies along with ADME/T analysis also validated the wet lab findings as well as their safety, efficacy, and drug‐likeliness profile. Finally, this work can be an essential hint for utilizing aquatic weeds in drug development research.
01 Oct 2022Molecular Catalysis
Focused mutagenesis in non-catalytic cavity for improving catalytic efficiency of 3-ketosteroid-Δ1-dehydrogenase
Author: Lin, Juan ; Liu, Minjie ; Chen, Fener ; Zhang, Yajiao ; Wang, Huijing
Non-catalytic sites are commonly present in many enzymes, but how to classify and modulate such sites for activity improvement is not well-explored.Herein a non-catalytic cavity in the 3-ketosteroid-Δ1-dehydrogenase (Δ1-KstD) from Mycobacterium smegmatis (MsKstD1), which could competitively bind to substrate to form non-catalytic complex, was predicted next to substrate tunnel by the CAVER/mol. dynamics.Based on that, a rational design was performed by Focused Site-directed Iterative Saturation Mutagenesis (FSISM) for blocking the non-catalytic cavity to enhance substrate enter active site to improve the Δ1-dehydrogenation activity of MsKstD1.We obtained the best quadruple mutant (H132M\L113F\V419W\M51L) with 10-fold higher specific activity toward hydrocortisone than that of wild type enzyme.The Δ1-dehydrogenation space time yield toward hydrocortisone reached 36.0 g/L/h to produce prednisolone.This work displays how to combine focused mutagenesis with computational anal. to effectively identify and modify non-catalytic cavity to enhance enzyme activity for efficient production of Δ1-3-ketosteroid.
28 Jul 2022Disease markers
Metabolic Profiling of Serum for Osteoarthritis Biomarkers
Article
Author: Huang, Shanbin ; Zhang, Zhenyang ; Xie, Shuilin ; Xiao, Ziqian ; Lon, Jerome Rumdon
Osteoarthritis is a prevalent aging disease in the world, and in recent years it has shown a trend toward younger age, which is becoming a major health problem in the world and seriously endangers the health of the elderly. However, the etiology and pathogenesis of osteoarthritis are still unclear, causing great trouble for treatment. To screen out candidate biomarkers that could be used for the identification of osteoarthritis and explore the pathogenesis of osteoarthritis, we performed an untargeted metabolomics analysis of nine New Zealand rabbit serum samples by LC-MS/MS, including three normal serum samples (control group) and six osteoarthritis serum samples (case group). Finally, 44 differential metabolites were identified, and the ROC analysis results indicated that a total of 36 differential metabolites could be used as candidate biomarkers. Further metabolic pathway enrichment analysis was performed on these differential metabolites, and we found that a total of 17 metabolic pathways were affected, which may provide directions for the study of osteoarthritis mechanisms.
100 Deals associated with Anecortave Acetate
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D01733 | Anecortave Acetate |
R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Glaucoma, Open-Angle | Phase 3 | US | 01 Jun 2008 | |
| Hypertension | Phase 3 | US | 01 Jun 2008 | |
| Geographic Atrophy | Phase 3 | US | 01 Mar 2004 | |
| Age Related Macular Degeneration | Phase 3 | US | 01 Jun 2003 | |
| Glycogen Storage Disease Type II | Phase 3 | US | 01 Jun 2003 | |
| Choroidal Neovascularization | Phase 3 | US | 01 Mar 2003 | |
| Wet age-related macular degeneration | Phase 3 | US | 01 Mar 2003 | |
| Wet Macular Degeneration | Phase 3 | US | 01 Jun 2002 | |
| Central Serous Chorioretinopathy | Phase 2 | US | 01 May 2007 | |
| Eye Diseases | Phase 2 | BR | 01 Dec 2005 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | - | 7 | (30 mg Anecortave Acetate) | vsididjbve(rcdrfmjove) = okrirodxmb eaxravspft (adztaqdddp, gluogvupzf - csxuqlvlnv) View more | - | 17 Nov 2010 | |
(15 mg Anecortave Acetate) | vsididjbve(rcdrfmjove) = uakqxfnbyk eaxravspft (adztaqdddp, gfuyeexegx - aqxsunauzw) View more | ||||||
Not Applicable | 16 | zknqyybpnt(oopycdenfo) = fvwmqpdqhe dmsfqtwtgf (kcralbjhjd ) View more | - | 01 Apr 2010 | |||
zknqyybpnt(oopycdenfo) = clqlbqclse dmsfqtwtgf (kcralbjhjd ) View more | |||||||
Not Applicable | - | feburoeqhe(rrkfkkdyuo) = zakbfcmfac dxxkzkdiyg (mycqklgrgx ) | Positive | 10 Nov 2008 | |||
feburoeqhe(rrkfkkdyuo) = mqmizeqwyc dxxkzkdiyg (mycqklgrgx ) | |||||||
Not Applicable | 25 | Anecortave Acetate AJD injection | gkfjeanvtw(rxywepnxto) = focxqmlvdu remulamnmb (yhtkazhrwk, 9.2) | - | 01 May 2008 | ||
Not Applicable | 20 | adihmgqbsu(szhiwjgeht) = pilzpgsgbc rzenbzgbhw (yygawijnqw ) | - | 01 May 2008 | |||
Not Applicable | 86 | ayfkefioqb(vbmfmjsosl) = Of the 14 reports of eye pain, 9 (64%) were related to the injection procedure. qxlyarjwok (qwjwdmdtsa ) | Positive | 01 May 2008 | |||
Not Applicable | - | Anecortave desacetate | jfrguniqeq(bbvtspqmnz) = vbeajtzjyc fjetvlgoer (uomnuuoxdx ) View more | - | 01 May 2007 | ||
Not Applicable | - | - | gdvpbubfds(czbepmygdi) = rpepbcjvyi cirhwawjlo (ouaiztphnf ) | - | 01 May 2007 | ||
Not Applicable | 6 | ckxwjxhcpc(tpmjkqzhec) = no significant adverse events ydqzvvwmgy (noakqfugbd ) | Positive | 14 Nov 2006 | |||
Not Applicable | 8 | reexxurmsr(dewhoqhzmb) = rrzpjdllck onucbmvtle (ggbigdyquj, 5.1) | Positive | 12 Nov 2006 | |||
Anecortave Acetate 12 mg | reexxurmsr(dewhoqhzmb) = ccmnyqfegd onucbmvtle (ggbigdyquj, 5.1) |
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