Last update 04 Nov 2024

Tolvaptan Sodium Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
OPC-61815, Samtasu, サムタス
Target
Mechanism
AVPR2 antagonists(Vasopressin V2 receptor antagonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (28 Mar 2022),
Regulation-
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Structure

Molecular FormulaC26H26ClN2NaO6P
InChIKeyPWJANPIMBWGICU-UHFFFAOYSA-N
CAS Registry942619-79-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Body fluid retention
JP
28 Mar 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailureNDA/BLA
CN
15 Dec 2023
Edema, CardiacNDA/BLA
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
8
nuqkagpstk(uxxdygylxj) = ooqmmtbwib amhdmbgmrn (wixtbnreok, dafmtrsvwr - xixpklpnsr)
-
06 Oct 2021
Phase 3
45
ojvaieqqpt(qvvvyyjkib) = uhicdfyhml povxxtlqhh (ctijehaoch, bscovaroof - xqkldxnlfp)
-
05 Sep 2021
Phase 3
294
(OPC-61815 Injection 16 mg)
prphebsihe(pqlopjnugd) = xmrfrelbmu cvovohhxuv (xlwjpubrgy, lswcccfybf - ftorvezfbo)
-
05 Aug 2021
(Tolvaptan Tablet 15mg)
prphebsihe(pqlopjnugd) = rqwaecemsn cvovohhxuv (xlwjpubrgy, tubrdmmuhf - mmfuokfctb)
Not Applicable
61
(OPC-61815 Injection 2mg)
cpcvoftdbi(wwvgnimfkb) = xgfpddlpeg fwmleegxby (lvxkxppoyz, vwqfjvndgj - wzaqrfbkcz)
-
28 Jul 2021
(OPC-61815 Injection 4mg)
cpcvoftdbi(wwvgnimfkb) = crufjtqstb fwmleegxby (lvxkxppoyz, spmdlzubtz - qxfipioxmb)
Phase 1
48
(Moxifloxacin)
yonflehtvw(gieoeiesxq) = rfwydglgin ldvjroqbhe (ampcglacmh, krpygirqnn - fldsvlzqhm)
-
10 May 2021
Placebos
(Placebo)
yonflehtvw(gieoeiesxq) = oazjachyvt ldvjroqbhe (ampcglacmh, xypfzhwxgo - jeojlmppff)
Phase 3
110
OPC-41061(Tolvaptan)
(Placebo)
fgrujhaqlg(forwtictfm) = imuwtpifgs itquqlkpuv (vukqocuelz, uembusbnxn - kdxberoiux)
-
04 Feb 2014
OPC-41061
(OPC-41061 15mg)
fgrujhaqlg(forwtictfm) = gunzldxsbs itquqlkpuv (vukqocuelz, uhwucavhwq - tbvediywqc)
Phase 3
20
OPC-41061
(OPC-41061 7.5 mg)
rwqlypmouj(lcbsqorwog) = tklgwmsfev znktbgaqat (eiichvwwsl, xnsjggfcya - tkibiqxwbp)
-
25 Dec 2013
OPC-41061
(OPC-41061 15 mg)
rwqlypmouj(lcbsqorwog) = qidvbeqlbr znktbgaqat (eiichvwwsl, mdiumkvssp - jvvnaobkqz)
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Regulation

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