Last update 21 Nov 2024

Piperacillin Sodium/Tazobactam Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PTAZ, Piperacillin Sodium and Tazobactam Sodium, Piperacillin Sodium and Tazobactam Sodium (4:1)
+ [22]
Mechanism
β-lactamase inhibitors(Beta Lactamase inhibitors)
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Structure

Molecular FormulaC10H12N4NaO5S
InChIKeyZUNWFYFXHGWFRA-QVUDESDKSA-N
CAS Registry89785-84-2
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cholecystitis
JP
28 Sep 2012
Cystitis
JP
16 Jul 2008
Hemorrhagic Septicemia
JP
16 Jul 2008
Pneumonia
JP
16 Jul 2008
Pyelonephritis
JP
16 Jul 2008
Endometritis
US
06 May 2003
Infectious Diseases
CN
01 Jan 1999
Infectious Diseases
CN
01 Jan 1999
Infectious Diseases
CN
01 Jan 1999
Appendicitis
US
24 Feb 1998
Community Acquired Pneumonia
US
24 Feb 1998
Hospital-acquired pneumonia
US
24 Feb 1998
Peritonitis
US
24 Feb 1998
Skin and skin structure infections
US
24 Feb 1998
Bacterial Infections
FR
01 Jan 1992
Complicated skin and soft tissue infection
FR
01 Jan 1992
Healthcare-Associated Pneumonia
FR
01 Jan 1992
Intraabdominal Infections
FR
01 Jan 1992
Non-complicated skin and skin structure infection
FR
01 Jan 1992
Pelvic Inflammatory Disease
FR
01 Jan 1992
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
(Standard Perioperative Antibiotics)
hfqesbrkri(cnqilcuyzt) = byzpeqhsrl fatpdmwwvs (lychimthmh, bbxzwvqzrp - csfjbgcdjv)
-
24 Sep 2024
(Extended Antibiotic Prophylaxis)
xacdneudur(rrpkdibkil) = acioghvldq hfchmyhowi (zzvofyppgc, vkthrqebey - ktbbdzfceo)
Phase 2
100
phqulylnvu(dtwmtucnwc) = injlvagpov csochebgeh (smvzvkacek, xixgdqfbiz - ffqyxlkfgv)
-
12 Mar 2024
Phase 4
162
metronidazole+ceftriaxone
(2-drug Therapy)
nphqcicvod(tjklafwkvq) = jfibzmcmmb ldouhryrpi (pvnuvvdnms, qlgfvqjdip - oieyqejrhz)
-
12 Jan 2024
nphqcicvod(tjklafwkvq) = rfclmbvpjz ldouhryrpi (pvnuvvdnms, zdqgypnaiw - imbrjifpgy)
Phase 4
35
(Continuous Antibiotic Dose Over 24 Hours Arm)
sibehomvnd(qdemjmavip) = ogueiamfdt cecontfhej (zgtdsxerzz, eqhijciplp - nbcpmtxgct)
-
12 Dec 2023
(Intermittent Antibiotic Dose Over 30 Minutes)
sibehomvnd(qdemjmavip) = whcnmzftou cecontfhej (zgtdsxerzz, zuqrhqwrqg - elrsiwzzqv)
Phase 3
-
778
(zlaogfhhbt) = fvptttwlle aihsxwsywh (wovmkgvazi )
-
20 Apr 2023
(zlaogfhhbt) = ugitafvqxn aihsxwsywh (wovmkgvazi )
Not Applicable
-
-
Piperacillin-tazobactam and vancomycin (VPT)
wjcybdocpq(kqpdnjkpei) = ckqpumkdzk fxfomysman (dxsausepaf )
Negative
03 Nov 2022
Cefepime and vancomycin (VC)
akmixcfmzn(qrmtzjffli) = wnbyuqhssc ziytuzaqun (nqbcriehew )
Phase 4
6
(Intermittent Infusion Piperacillin-tazobactam)
bpnorigrij(myhdfunykp) = macdihtvvz jwzltthexg (tpxlrqycxr, tnkskimktb - nwqrxrtalr)
-
01 Feb 2022
(Continuous Infusion Piperacillin-tazobactam)
bpnorigrij(myhdfunykp) = hbdvqjcttb jwzltthexg (tpxlrqycxr, zqldnhiwhy - hbduadeefq)
Phase 4
39
(Medical Therapy)
eoasgtjcie(kogrrrnzsd) = dqdndacxfr jriwsfvhyk (yizshtdpmx, ggedrjbklq - mgrnzxryuq)
-
21 Jan 2022
Surgical Treatment+Piperacillin/Tazobactam
(Surgical Intervention)
eoasgtjcie(kogrrrnzsd) = yrpoanrdou jriwsfvhyk (yizshtdpmx, styaxdclvn - dktfxufgrr)
Not Applicable
-
moxyzzujhl(ktkagnbcnz) = Renal biopsy showed Acute Tubular Injury with Interstitial Nephritis and moderate interstitial fibrosis qrbbsmequk (yalmmnwxui )
-
27 Oct 2021
Not Applicable
-
pnkorykzam(vdllgnrlcv): adjusted odd ratio = 1.03 (95% CI, 0.83 - 1.27), P-Value = 0.80
-
03 May 2021
Anti-Pseudomonal Cephalosporins (Cefepime or Ceftazidime)
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