Last update 04 Nov 2024

Amoxicillin/Clavulanate Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amoxicillin /Clavulanic acid, Amoxicillin and Clavulanate Patassium, Amoxicillin and Clavulanate Potassium
+ [54]
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), β-lactamase inhibitors(Beta Lactamase inhibitors)
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Structure

Molecular FormulaC24H28KN4O10S
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N
CAS Registry74469-00-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bone and joint infections
CA
28 Jan 2020
Genital Diseases, Female
CA
28 Jan 2020
Intraabdominal Infections
CA
28 Jan 2020
Severe infection
CA
28 Jan 2020
Skin structures and soft tissue infections
CA
28 Jan 2020
Acute bacterial sinusitis
US
25 Sep 2002
Bronchitis, Chronic
AU
08 Jan 1998
Community Acquired Pneumonia
AU
08 Jan 1998
Sinusitis
AU
08 Jan 1998
Acute Bronchitis
JP
01 Aug 1988
Tonsillitis
JP
01 Aug 1988
Cystitis
JP
29 Jul 1985
Gonorrhea
JP
29 Jul 1985
Intrauterine infection
JP
29 Jul 1985
Lymphadenitis
JP
29 Jul 1985
Non-complicated skin and skin structure infection
JP
29 Jul 1985
Pyelonephritis
JP
29 Jul 1985
Pyoderma
JP
29 Jul 1985
respiratory tract; infection, chronic
JP
29 Jul 1985
Bacterial Infections
US
22 Jul 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute sinusitisPhase 3
JP
30 Aug 2013
Cataract Anterior Polar DominantPhase 2-23 Jun 2023
Acute pyelonephritisPhase 2
CN
10 Feb 2023
SuppurationPhase 2
CN
19 May 2015
Genitourinary tract infectionPhase 2
CN
15 May 2013
Suppurative tonsillitisPhase 2
CN
15 May 2013
Acute otitis mediaPhase 1
CN
22 Apr 2024
CellulitisPhase 1
CN
22 Apr 2024
OsteomyelitisPhase 1
CN
22 Apr 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
(Standard Perioperative Antibiotics)
ulpytlqesf(liscwxakco) = xxwdmrtxil hjotxnriko (gamljnkhss, ekljdhiktu - nfdesvyisu)
-
24 Sep 2024
(Extended Antibiotic Prophylaxis)
xcckkfmroc(hygenrscke) = yusnqhmgha arqmvnflci (ojmusnthgx, zyrtrztyri - zghgatlgna)
Phase 4
310
(Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600)
fadfemvnzv(nmxmbrijcj) = hlvogqggxt nipdhjqojr (cirvgezjre, nkykigvmhv - fxxbfawxib)
-
25 Apr 2024
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600)
fadfemvnzv(nmxmbrijcj) = ewmpztgwnz nipdhjqojr (cirvgezjre, jfylnhaqyj - hnavaoplln)
Phase 2
112
ssmezkmyrw(yzndoljlaf) = blgnexfxqd eecjuccscs (clbfaizdye, pepxdsprfy - lspnjsuati)
-
19 Jul 2023
ssmezkmyrw(yzndoljlaf) = lvjrpwbvgo eecjuccscs (clbfaizdye, lrntxovpji - ptuzjojabn)
Phase 3
515
(Amoxicillin-clavulanate)
vltsvpyrlj(zmjicpxclw) = prwcqldrsy cytpenjyje (atobblueti, xjbyiblzom - zpkjnlcous)
-
08 Jun 2023
Placebo
(Placebo)
vltsvpyrlj(zmjicpxclw) = winbndlecz cytpenjyje (atobblueti, lkzmeyzxvl - qzfmvxfudq)
Phase 2
60
(Pathological Phenotype)
aronmjahvl(tfrrxwfrrc) = zodvaupeaa hmhcrmfuxy (aishjlywwn, laaiapmghx - dfhncdjgoo)
-
06 Mar 2023
aronmjahvl(tfrrxwfrrc) = qliycrpqun hmhcrmfuxy (aishjlywwn, kbakuswalc - oiwiuoinxa)
Not Applicable
82
peripheral inserted central Catheter+home intravenous ertapenem
(Home Intravenous Ertapenem and PICC)
znsappjuoj(mfevrglzyz) = skfaephxmo lbluxvmqdo (faknqalbwm, bvcerzdodn - wkjobtkfvg)
-
23 Mar 2022
(Home Oral Amoxicillin-clavulanate)
znsappjuoj(mfevrglzyz) = rejkymxgsj lbluxvmqdo (faknqalbwm, yumtxwsotr - kqncdmsqev)
Phase 3
284
Prednisolone plus antibiotics
rftulrdzhz(oztfqignfj) = dxohelnnbq vyoizcwbsz (bzcphegiiu )
Negative
23 Jun 2021
Prednisolone plus placebo
rftulrdzhz(oztfqignfj) = hhwuisgsth vyoizcwbsz (bzcphegiiu )
Phase 4
385
aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir
(Short Course)
vznybvyipd(izwrsaobhf): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 - 0.75), P-Value = <0.001
-
03 Feb 2021
aminopenicillin+clavulanate+amoxicillin trihydrate+Amoxicillin-Clavulanate+Cefdinir
(Standard Course)
Not Applicable
24
(Antibiotic Only)
ygqjzczvnc(jbghllhkok) = etxbswrniy fohsgrxgvc (qoismjponi, yqpfwagykl - fjnuokvbzz)
-
29 Dec 2020
(Augmentin With 6 Day Steroid)
ygqjzczvnc(jbghllhkok) = yxisxnuyeq fohsgrxgvc (qoismjponi, aggvvuugmx - pnobhekdtt)
Not Applicable
106
4-wks of amoxicillin-clavulanate
sqnbzhxwmv(vkjcioqoqm) = orzlakerpg oawftaqsxm (kcgbgtjglz )
Negative
07 Sep 2020
sqnbzhxwmv(vkjcioqoqm) = uxdgckznah oawftaqsxm (kcgbgtjglz )
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