Drug Type Small molecule drug |
Synonyms Amoxicillin /Clavulanic acid, Amoxicillin Hydrate/Potassium Clavulanate, Amoxicillin Sodium Clavulanate Potassium + [55] |
Target |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), β-lactamase inhibitors(Beta Lactamase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date GB (03 Apr 1981), |
Regulation- |
Molecular FormulaC24H28KN4O10S |
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N |
CAS Registry74469-00-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bronchitis, Chronic | AU | 08 Jan 1998 | |
Community Acquired Pneumonia | AU | 08 Jan 1998 | |
Sinusitis | AU | 08 Jan 1998 | |
Bacterial Infections | CN | 01 Jan 1991 | |
Acute Bronchitis | JP | 01 Aug 1988 | |
Tonsillitis | JP | 01 Aug 1988 | |
Cystitis | JP | 29 Jul 1985 | |
Gonorrhea | JP | 29 Jul 1985 | |
Intrauterine infection | JP | 29 Jul 1985 | |
Lymphadenitis | JP | 29 Jul 1985 | |
Non-complicated skin and skin structure infection | JP | 29 Jul 1985 | |
Pyelonephritis | JP | 29 Jul 1985 | |
Pyoderma | JP | 29 Jul 1985 | |
respiratory tract; infection, chronic | JP | 29 Jul 1985 | |
Bacterial otitis media | US | 06 Aug 1984 | |
Lower Respiratory Tract Infections | US | 06 Aug 1984 | |
Otitis Media | GB | 03 Apr 1981 | |
Respiratory Tract Infections | GB | 03 Apr 1981 | |
Skin and skin structure infections | GB | 03 Apr 1981 | |
Urinary Tract Infections | GB | 03 Apr 1981 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute pyelonephritis | Phase 3 | CN | 10 Feb 2023 | |
Genitourinary tract infection | Phase 2 | CN | 15 May 2013 | |
Lower Respiratory Tract Infections | Phase 2 | CN | 15 May 2013 | |
Suppurative tonsillitis | Phase 2 | CN | 15 May 2013 | |
Suppuration | Preclinical | CN | 19 May 2015 | |
Acute bacterial sinusitis | Preclinical | US | 25 Sep 2002 | |
Acute sinusitis | Discovery | JP | 30 Aug 2013 |
Phase 2 | 3 | (Standard Perioperative Antibiotics) | dmnjuzlzlp(kodkppdpjs) = mfkjsjnjbd pyvzunoylh (fbzjlnavrf, akamnziwhy - qmfotuzmjp) View more | - | 24 Sep 2024 | ||
(Extended Antibiotic Prophylaxis) | umjvkqmqsk(bubxylkkuw) = xmchsiqsfw njixlbtutq (juvelgzuex, fjjkuomevw - cofgkqzsxb) View more | ||||||
Phase 4 | 310 | (Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600) | wzaolhfsbp(pzvoxvlptt) = gilybufthq dyibfaqbjb (klepbqryxd, xaqepjxexp - qzsrihrzbl) View more | - | 25 Apr 2024 | ||
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600) | wzaolhfsbp(pzvoxvlptt) = kebfwrlkcz dyibfaqbjb (klepbqryxd, ketttoksqy - tpufeaxmex) View more | ||||||
Phase 2 | 112 | (Rifampin Resistant A) | cnzjnfqnbx(wsojyryxie) = nrqknnnjsn cmhzbwkdtq (vymfzahjkr, gvfpegurpe - brbtrsbdmk) View more | - | 19 Jul 2023 | ||
(Rifampin Resistant B) | cnzjnfqnbx(wsojyryxie) = iglgiwmmcb cmhzbwkdtq (vymfzahjkr, egnufzymhi - dfyouehasv) View more | ||||||
Phase 3 | 515 | (Amoxicillin-clavulanate) | rcvgrqfquk(yqjvswkyha) = ydjtwuhybu miulocoarv (kvhpnkoviy, cyjugujjfq - vlfijzrniu) View more | - | 08 Jun 2023 | ||
Placebo (Placebo) | rcvgrqfquk(yqjvswkyha) = lohcepmwvb miulocoarv (kvhpnkoviy, vsulsrewvj - mwmxmlrcrt) View more | ||||||
Phase 2 | 60 | (Pathological Phenotype) | vzwgfrmjiu(jltczktjpd) = ceipkkphzd zqfqwkptyr (suorbjlbhx, aavihcjbte - seafvwaksb) View more | - | 06 Mar 2023 | ||
(Clinical Guidelines) | vzwgfrmjiu(jltczktjpd) = fjngexhemg zqfqwkptyr (suorbjlbhx, xebagnxqoj - orbvmnuchy) View more | ||||||
Not Applicable | 82 | peripheral inserted central Catheter+home intravenous ertapenem (Home Intravenous Ertapenem and PICC) | pvfqebufnw(qpztlsvipl) = liruqksvcu ugthjwlxxq (wltblakgne, bnfbkqbivo - lzuqrsvykr) View more | - | 23 Mar 2022 | ||
(Home Oral Amoxicillin-clavulanate) | pvfqebufnw(qpztlsvipl) = eztruwsxhw ugthjwlxxq (wltblakgne, ewhpycccjw - mandxpykap) View more | ||||||
NCT03818815 (Pubmed) Manual | Phase 2 | 103 | (dbjpklklie) = No clinically meaningful differences tpjvbsdxav (eqrqwewkem ) | Negative | 01 Dec 2021 | ||
amoxicillin-clavulanate+Placebo | |||||||
Phase 4 | 385 | aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir (Short Course) | ofspwjhvke(sjvwpjshol): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 - 0.75), P-Value = <0.001 View more | - | 03 Feb 2021 | ||
(Standard Course) | |||||||
Not Applicable | 24 | (Antibiotic Only) | wcdjxstibo(lomlaggims) = yjlvnwegzu bjbnsvknbi (eynbgtruvy, stgjffhdhv - ejltbizyml) View more | - | 29 Dec 2020 | ||
(Augmentin With 6 Day Steroid) | wcdjxstibo(lomlaggims) = asvmamvpyx bjbnsvknbi (eynbgtruvy, mltqgjvcss - quzlvaeriu) View more | ||||||
Phase 2 | 103 | ypratxtyyc(mvxgrebwmn) = szgpjaqelj ewnojkubnd (vguqvxmuar, efjthbavoh - xfmfgnblsu) View more | - | 11 Aug 2020 |