Last update 21 Nov 2024

Amoxicillin/Clavulanate Potassium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amoxicillin /Clavulanic acid, Amoxicillin Hydrate/Potassium Clavulanate, Amoxicillin Sodium Clavulanate Potassium
+ [55]
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), β-lactamase inhibitors(Beta Lactamase inhibitors)
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Structure

Molecular FormulaC24H28KN4O10S
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N
CAS Registry74469-00-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bronchitis, Chronic
AU
08 Jan 1998
Community Acquired Pneumonia
AU
08 Jan 1998
Sinusitis
AU
08 Jan 1998
Bacterial Infections
CN
01 Jan 1991
Acute Bronchitis
JP
01 Aug 1988
Tonsillitis
JP
01 Aug 1988
Cystitis
JP
29 Jul 1985
Gonorrhea
JP
29 Jul 1985
Intrauterine infection
JP
29 Jul 1985
Lymphadenitis
JP
29 Jul 1985
Non-complicated skin and skin structure infection
JP
29 Jul 1985
Pyelonephritis
JP
29 Jul 1985
Pyoderma
JP
29 Jul 1985
respiratory tract; infection, chronic
JP
29 Jul 1985
Bacterial otitis media
US
06 Aug 1984
Lower Respiratory Tract Infections
US
06 Aug 1984
Otitis Media
GB
03 Apr 1981
Respiratory Tract Infections
GB
03 Apr 1981
Skin and skin structure infections
GB
03 Apr 1981
Urinary Tract Infections
GB
03 Apr 1981
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute pyelonephritisPhase 3
CN
10 Feb 2023
Genitourinary tract infectionPhase 2
CN
15 May 2013
Lower Respiratory Tract InfectionsPhase 2
CN
15 May 2013
Suppurative tonsillitisPhase 2
CN
15 May 2013
SuppurationPreclinical
CN
19 May 2015
Acute bacterial sinusitisPreclinical
US
25 Sep 2002
Acute sinusitisDiscovery
JP
30 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
(Standard Perioperative Antibiotics)
dmnjuzlzlp(kodkppdpjs) = mfkjsjnjbd pyvzunoylh (fbzjlnavrf, akamnziwhy - qmfotuzmjp)
-
24 Sep 2024
(Extended Antibiotic Prophylaxis)
umjvkqmqsk(bubxylkkuw) = xmchsiqsfw njixlbtutq (juvelgzuex, fjjkuomevw - cofgkqzsxb)
Phase 4
310
(Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600)
wzaolhfsbp(pzvoxvlptt) = gilybufthq dyibfaqbjb (klepbqryxd, xaqepjxexp - qzsrihrzbl)
-
25 Apr 2024
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600)
wzaolhfsbp(pzvoxvlptt) = kebfwrlkcz dyibfaqbjb (klepbqryxd, ketttoksqy - tpufeaxmex)
Phase 2
112
cnzjnfqnbx(wsojyryxie) = nrqknnnjsn cmhzbwkdtq (vymfzahjkr, gvfpegurpe - brbtrsbdmk)
-
19 Jul 2023
cnzjnfqnbx(wsojyryxie) = iglgiwmmcb cmhzbwkdtq (vymfzahjkr, egnufzymhi - dfyouehasv)
Phase 3
515
(Amoxicillin-clavulanate)
rcvgrqfquk(yqjvswkyha) = ydjtwuhybu miulocoarv (kvhpnkoviy, cyjugujjfq - vlfijzrniu)
-
08 Jun 2023
Placebo
(Placebo)
rcvgrqfquk(yqjvswkyha) = lohcepmwvb miulocoarv (kvhpnkoviy, vsulsrewvj - mwmxmlrcrt)
Phase 2
60
(Pathological Phenotype)
vzwgfrmjiu(jltczktjpd) = ceipkkphzd zqfqwkptyr (suorbjlbhx, aavihcjbte - seafvwaksb)
-
06 Mar 2023
vzwgfrmjiu(jltczktjpd) = fjngexhemg zqfqwkptyr (suorbjlbhx, xebagnxqoj - orbvmnuchy)
Not Applicable
82
peripheral inserted central Catheter+home intravenous ertapenem
(Home Intravenous Ertapenem and PICC)
pvfqebufnw(qpztlsvipl) = liruqksvcu ugthjwlxxq (wltblakgne, bnfbkqbivo - lzuqrsvykr)
-
23 Mar 2022
(Home Oral Amoxicillin-clavulanate)
pvfqebufnw(qpztlsvipl) = eztruwsxhw ugthjwlxxq (wltblakgne, ewhpycccjw - mandxpykap)
Phase 2
103
(dbjpklklie) = No clinically meaningful differences tpjvbsdxav (eqrqwewkem )
Negative
01 Dec 2021
Phase 4
385
aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir
(Short Course)
ofspwjhvke(sjvwpjshol): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 - 0.75), P-Value = <0.001
-
03 Feb 2021
aminopenicillin+clavulanate+amoxicillin trihydrate+Amoxicillin-Clavulanate+Cefdinir
(Standard Course)
Not Applicable
24
(Antibiotic Only)
wcdjxstibo(lomlaggims) = yjlvnwegzu bjbnsvknbi (eynbgtruvy, stgjffhdhv - ejltbizyml)
-
29 Dec 2020
(Augmentin With 6 Day Steroid)
wcdjxstibo(lomlaggims) = asvmamvpyx bjbnsvknbi (eynbgtruvy, mltqgjvcss - quzlvaeriu)
Phase 2
103
ypratxtyyc(mvxgrebwmn) = szgpjaqelj ewnojkubnd (vguqvxmuar, efjthbavoh - xfmfgnblsu)
-
11 Aug 2020
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