Drug Type Small molecule drug |
Synonyms Amoxicillin /Clavulanic acid, Amoxicillin and Clavulanate Patassium, Amoxicillin and Clavulanate Potassium + [54] |
Target |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), β-lactamase inhibitors(Beta Lactamase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date GB (03 Apr 1981), |
Regulation- |
Molecular FormulaC24H28KN4O10S |
InChIKeyVKJFJOFNYVFTRZ-ZVDZYBSKSA-N |
CAS Registry74469-00-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bone and joint infections | CA | 28 Jan 2020 | |
Genital Diseases, Female | CA | 28 Jan 2020 | |
Intraabdominal Infections | CA | 28 Jan 2020 | |
Severe infection | CA | 28 Jan 2020 | |
Skin structures and soft tissue infections | CA | 28 Jan 2020 | |
Acute bacterial sinusitis | US | 25 Sep 2002 | |
Bronchitis, Chronic | AU | 08 Jan 1998 | |
Community Acquired Pneumonia | AU | 08 Jan 1998 | |
Sinusitis | AU | 08 Jan 1998 | |
Acute Bronchitis | JP | 01 Aug 1988 | |
Tonsillitis | JP | 01 Aug 1988 | |
Cystitis | JP | 29 Jul 1985 | |
Gonorrhea | JP | 29 Jul 1985 | |
Intrauterine infection | JP | 29 Jul 1985 | |
Lymphadenitis | JP | 29 Jul 1985 | |
Non-complicated skin and skin structure infection | JP | 29 Jul 1985 | |
Pyelonephritis | JP | 29 Jul 1985 | |
Pyoderma | JP | 29 Jul 1985 | |
respiratory tract; infection, chronic | JP | 29 Jul 1985 | |
Bacterial Infections | US | 22 Jul 1985 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute sinusitis | Phase 3 | JP | 30 Aug 2013 | |
Cataract Anterior Polar Dominant | Phase 2 | - | 23 Jun 2023 | |
Acute pyelonephritis | Phase 2 | CN | 10 Feb 2023 | |
Suppuration | Phase 2 | CN | 19 May 2015 | |
Genitourinary tract infection | Phase 2 | CN | 15 May 2013 | |
Suppurative tonsillitis | Phase 2 | CN | 15 May 2013 | |
Acute otitis media | Phase 1 | CN | 22 Apr 2024 | |
Cellulitis | Phase 1 | CN | 22 Apr 2024 | |
Osteomyelitis | Phase 1 | CN | 22 Apr 2024 |
Phase 2 | 3 | (Standard Perioperative Antibiotics) | ulpytlqesf(liscwxakco) = xxwdmrtxil hjotxnriko (gamljnkhss, ekljdhiktu - nfdesvyisu) View more | - | 24 Sep 2024 | ||
(Extended Antibiotic Prophylaxis) | xcckkfmroc(hygenrscke) = yusnqhmgha arqmvnflci (ojmusnthgx, zyrtrztyri - zghgatlgna) View more | ||||||
Phase 4 | 310 | (Participants With Acute Otitis Media (AOM) Receiving Augmentin (ES)-600) | fadfemvnzv(nmxmbrijcj) = hlvogqggxt nipdhjqojr (cirvgezjre, nkykigvmhv - fxxbfawxib) View more | - | 25 Apr 2024 | ||
(Participants With Acute Bacterial Rhinosinusitis (ABRS) Receiving Augmentin (ES)-600) | fadfemvnzv(nmxmbrijcj) = ewmpztgwnz nipdhjqojr (cirvgezjre, jfylnhaqyj - hnavaoplln) View more | ||||||
Phase 2 | 112 | (Rifampin Resistant A) | ssmezkmyrw(yzndoljlaf) = blgnexfxqd eecjuccscs (clbfaizdye, pepxdsprfy - lspnjsuati) View more | - | 19 Jul 2023 | ||
(Rifampin Resistant B) | ssmezkmyrw(yzndoljlaf) = lvjrpwbvgo eecjuccscs (clbfaizdye, lrntxovpji - ptuzjojabn) View more | ||||||
Phase 3 | 515 | (Amoxicillin-clavulanate) | vltsvpyrlj(zmjicpxclw) = prwcqldrsy cytpenjyje (atobblueti, xjbyiblzom - zpkjnlcous) View more | - | 08 Jun 2023 | ||
Placebo (Placebo) | vltsvpyrlj(zmjicpxclw) = winbndlecz cytpenjyje (atobblueti, lkzmeyzxvl - qzfmvxfudq) View more | ||||||
Phase 2 | 60 | (Pathological Phenotype) | aronmjahvl(tfrrxwfrrc) = zodvaupeaa hmhcrmfuxy (aishjlywwn, laaiapmghx - dfhncdjgoo) View more | - | 06 Mar 2023 | ||
(Clinical Guidelines) | aronmjahvl(tfrrxwfrrc) = qliycrpqun hmhcrmfuxy (aishjlywwn, kbakuswalc - oiwiuoinxa) View more | ||||||
Not Applicable | 82 | peripheral inserted central Catheter+home intravenous ertapenem (Home Intravenous Ertapenem and PICC) | znsappjuoj(mfevrglzyz) = skfaephxmo lbluxvmqdo (faknqalbwm, bvcerzdodn - wkjobtkfvg) View more | - | 23 Mar 2022 | ||
(Home Oral Amoxicillin-clavulanate) | znsappjuoj(mfevrglzyz) = rejkymxgsj lbluxvmqdo (faknqalbwm, yumtxwsotr - kqncdmsqev) View more | ||||||
Phase 3 | 284 | Prednisolone plus antibiotics | rftulrdzhz(oztfqignfj) = dxohelnnbq vyoizcwbsz (bzcphegiiu ) View more | Negative | 23 Jun 2021 | ||
Prednisolone plus placebo | rftulrdzhz(oztfqignfj) = hhwuisgsth vyoizcwbsz (bzcphegiiu ) View more | ||||||
Phase 4 | 385 | aminopenicillin+clavulanate+amoxicillin trihydrate+Cefdinir (Short Course) | vznybvyipd(izwrsaobhf): Pr (Higher DOOR in Short-Course) = 0.69 (95% CI, 0.63 - 0.75), P-Value = <0.001 View more | - | 03 Feb 2021 | ||
(Standard Course) | |||||||
Not Applicable | 24 | (Antibiotic Only) | ygqjzczvnc(jbghllhkok) = etxbswrniy fohsgrxgvc (qoismjponi, yqpfwagykl - fjnuokvbzz) View more | - | 29 Dec 2020 | ||
(Augmentin With 6 Day Steroid) | ygqjzczvnc(jbghllhkok) = yxisxnuyeq fohsgrxgvc (qoismjponi, aggvvuugmx - pnobhekdtt) View more | ||||||
Not Applicable | 106 | 4-wks of amoxicillin-clavulanate | sqnbzhxwmv(vkjcioqoqm) = orzlakerpg oawftaqsxm (kcgbgtjglz ) View more | Negative | 07 Sep 2020 | ||
sqnbzhxwmv(vkjcioqoqm) = uxdgckznah oawftaqsxm (kcgbgtjglz ) View more |