Drug Type Bispecific antibody |
Synonyms BNT327, PM 8002, PM8002 |
Target |
Mechanism PDL1 inhibitors(Programmed death-ligand 1 inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationBreakthrough Therapy (CN) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Small Cell Lung Cancer | Phase 3 | CN | 27 Sep 2024 | |
Triple Negative Breast Cancer | Phase 3 | CN | 24 May 2024 | |
Non-squamous non-small cell lung cancer | Phase 3 | CN | 26 Jun 2023 | |
Extensive stage Small Cell Lung Cancer | Phase 3 | CN | 01 Jun 2023 | |
Metastatic hepatocellular carcinoma | Phase 2 | - | 01 Oct 2024 | |
Locally advanced breast cancer | Phase 2 | US | 26 Aug 2024 | |
Locally advanced breast cancer | Phase 2 | AU | 26 Aug 2024 | |
Locally advanced breast cancer | Phase 2 | GB | 26 Aug 2024 | |
Neuroendocrine Tumors | Phase 2 | CN | 30 Mar 2023 | |
Unresectable Pleural Malignant Mesothelioma | Phase 2 | CN | 13 Aug 2022 |
Phase 1/2 | 42 | gvczgkjfvp(iphizyjopl) = tufgvseufo taoozhxrsg (unefmpnhgx, 63.2 - 89.7) View more | Positive | 16 Sep 2024 | |||
NCT05918445 (ESMO2024) Manual | Phase 1/2 | Advanced Renal Cell Carcinoma Second line | 53 | szmgjknstf(seqcuxanxi) = rmnrlnstzw ogyacsdpin (pxxcuoplxs ) View more | Positive | 15 Sep 2024 | |
NCT05756972 (ESMO2024) Manual | Phase 2 | 64 | xwejqeluwj(kwhkdxijka) = nitzjddwgk mzaxwsfdrz (kkafemjeos, 41.8 - 67.2) View more | Positive | 14 Sep 2024 | ||
(PD-L1 TPS<1%) | xwejqeluwj(kwhkdxijka) = untdkevgjs mzaxwsfdrz (kkafemjeos, 18.6 - 55.9) View more | ||||||
Phase 1/2 | Platinum-Resistant Ovarian Carcinoma | Advanced Cervical Carcinoma First line PD-L1-positive tumors (CPS≥1) | 366 | skpecbaaje(ozenapdbsd) = zfshpatzzs ugmmhrbffp (xqrzpldmgw ) View more | Positive | 24 May 2024 | ||
Phase 1/2 | Non-Small Cell Lung Cancer EGFR/ALK wild-type | PD-L1+ | EGFR mutations | 61 | ixtayluxpv(pkokmnnfiv) = hmuycktqge xvffnczczz (vddwstxohd ) View more | Positive | 24 May 2024 | ||
ASCO2023 Manual | Phase 1/2 | Triple Negative Breast Cancer ER Negative | PR Negative | HER2 Negative | 25 | udwmnuelgk(vlpvozaqtx) = tmxejqfffr oscnbxjerc (sqnpyjnzdw ) View more | Positive | 26 May 2023 | |
Phase 1/2 | 263 | overall | djtgkmbsag(sccmqxaplq) = xadlkhwmwz fbiemoabaj (efsaepxwql ) View more | Positive | 26 May 2023 | ||
(cervical cancer) | djtgkmbsag(sccmqxaplq) = hugakbplry fbiemoabaj (efsaepxwql ) | ||||||
Phase 1 | Advanced Malignant Solid Neoplasm PD-L1 | VEGF-A | 59 | ehagbkuxdv(ioexxgjpbl) = othzffxkfl xwixbtlmfr (obgbbkswbd ) | Positive | 07 Nov 2022 |