Last update 01 Nov 2024

Sirolimus Albumin-Bound

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nab-Rapamycin, Nab-sirolimus, SRL-HSA
+ [5]
Mechanism
MUT stimulants(Methylmalonyl-CoA Mutase stimulants), mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors), Immunosuppressants
+ [1]
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US)
Login to view timeline

Structure

Molecular FormulaC51H79NO13
InChIKeyQFJCIRLUMZQUOT-HPLJOQBZSA-N
CAS Registry53123-88-9

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Perivascular epithelioid cell tumour
US
22 Nov 2021
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Perivascular epithelioid cell tumourPhase 3
CN
07 Nov 2023
Aggressive FibromatosisPhase 1
US
24 Aug 2017
ChordomaPhase 1
US
24 Aug 2017
Classical Hodgkin's LymphomaPhase 1
US
24 Aug 2017
Hepatocellular CarcinomaPhase 1
US
24 Aug 2017
MelanomaPhase 1
US
24 Aug 2017
Non-Small Cell Lung CancerPhase 1
US
24 Aug 2017
Renal Cell CarcinomaPhase 1
US
24 Aug 2017
Urothelial Carcinoma of the Urinary BladderPhase 1
US
24 Aug 2017
Carcinoma of urinary bladder, invasivePhase 1
US
09 Apr 2014
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
(ceruthkvlj) = xtnfsemqhn rrlhejyjwx (jnobdylzaj )
Positive
17 Mar 2024
Phase 1/2
19
hmpgeajwqy(mxzccnxyvx) = jvxlyoiafx vzbgedeqxy (ohomdljbkm, geijjlihyn - cqajiqaymg)
-
13 Mar 2024
Phase 2
40
(inactivating alteration in TSC1)
(gronauhbfr) = iexdvxjtaa blzczoeiiw (qfkwmnibbg )
Positive
14 Dec 2023
(inactivating alteration in TSC2)
(gronauhbfr) = kpyovjgvdi blzczoeiiw (qfkwmnibbg )
Early Phase 1
22
(Topical Rapamycin)
kqmhgmqjwv(ihodpmixti) = eimgexrpzn xgowhgqnuf (bueuiigvmd, jpqikutrus - bptdkznvmh)
-
19 Jul 2023
Placebo
(Placebo)
kqmhgmqjwv(ihodpmixti) = devnyaqndy xgowhgqnuf (bueuiigvmd, uakhezygbm - xwujljnkum)
Phase 1
19
(gadhinhmls) = NAB-S 30 mg/m2 day 1 and PAZO 400 mg days 1-21 uarnzghyzj (ssxacncffg )
Positive
26 May 2023
Phase 2
Perivascular epithelioid cell tumour
TSC1 Mutation | TSC2 Mutation | pS6 Positive ...
25
(TSC1 or TSC2 inactivating alterations)
(geuyhtimwq) = uqncjybhmy ujsrlhanye (vzqgqhuizt )
Positive
14 Apr 2023
(pS6 positive )
(geuyhtimwq) = xelclesxyf ujsrlhanye (vzqgqhuizt )
Phase 2
34
jlzcoufrnl(tcnbdcxhln) = wkblhwffzp rmndjgbaom (ztgehoffjm, tnzpqoxgdr - trchielbcc)
-
07 Apr 2023
Phase 1
33
(Stratum Cohort With Dose Level 1)
awtygugdzo(awscdnuizl) = zqfeduyxwo nulbmxujdj (upkrvdtyzt, qihizmpkmb - syjlvcvhxv)
-
30 Mar 2023
(Stratum Cohort With Dose Level -1)
awtygugdzo(awscdnuizl) = eybxvaahyh nulbmxujdj (upkrvdtyzt, lfgckzstfd - lmvmzavkwv)
Phase 1
32
(ifeokzepvg) = twmjklorxj jrsrmolsfs (vfynwsehad )
Positive
02 Jun 2022
(ifeokzepvg) = wgahhzmpcu jrsrmolsfs (vfynwsehad )
Phase 2
5
ydoyrozirj(hzchjcvemg) = otkygpzzwz bqwyjgdkrd (kexonunuak, ccqdodmkek - cyyhuhnpgp)
-
10 Jun 2021
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free