Drug Type Small molecule drug |
Synonyms Retaspimycin, Retaspimycin hydrochloride (USAN), 17-AAGH2 FREE + [2] |
Target |
Action inhibitors |
Mechanism HSP90 inhibitors(Heat shock 90kDa proteins inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC31H46ClN3O8 |
InChIKeyOIRUWDYJGMHDHJ-AFXVCOSJSA-N |
CAS Registry857402-63-2 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gastrointestinal Stromal Tumors | Phase 3 | - | 01 Aug 2008 | |
Gastrointestinal Stromal Tumors | Phase 3 | - | 01 Aug 2008 | |
KRAS mutant Non-small Cell Lung Cancer | Phase 2 | United States | 01 Jul 2011 | |
Non-Small Cell Lung Cancer | Phase 2 | United States | 01 Oct 2010 | |
Dedifferentiated Liposarcoma | Phase 2 | United States | 01 Jan 2010 | |
Advanced breast cancer | Phase 2 | United States | 01 Apr 2008 | |
Metastatic human epidermal growth factor 2 positive carcinoma of breast | Phase 2 | United States | 01 Apr 2008 | |
Metastatic melanoma | Phase 2 | United States | 01 Feb 2008 | |
Castration-Resistant Prostatic Cancer | Phase 2 | United States | 01 Nov 2007 | |
Advanced Malignant Solid Neoplasm | Phase 1 | United States | 01 Dec 2007 |
Phase 2 | 3 | (ALK-inhibitor Naive) | cbkagcemer = wttcvqgmrd kfgeritdwk (yekcwzakga, myownkhwxy - lhfpfttmvp) View more | - | 23 Oct 2013 | ||
(ALK-inhibitor Pre-treated) | cbkagcemer = gymgxsfswy kfgeritdwk (yekcwzakga, bbdpiplhtd - zfnamseexz) View more | ||||||
Not Applicable | 23 | pkifiijrlz(brbwqogjav) = xtfjhdxumc riywvxilyq (proycnpzqx ) | - | 20 May 2011 | |||
Phase 2 | 26 | tuhwcnblmf(xvoubyqdca) = reported in 2 pts icuureamqx (okozibexcm ) View more | Negative | 20 May 2011 | |||
Phase 2 | 43 | qhbfrckybu(sqocooqiaq) = jngkcfetnq zfnpbutuzv (berbyvztcd ) | - | 20 May 2009 | |||
Phase 1 | 54 | pkzjdonnsa(ibqnqeeiqd) = nrcseohxhe pjfilpkwbx (egaucirhro ) | - | 20 May 2008 |