Last update 30 Mar 2025

Retaspimycin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Retaspimycin, Retaspimycin hydrochloride (USAN), 17-AAGH2 FREE
+ [2]
Target
Action
inhibitors
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC31H46ClN3O8
InChIKeyOIRUWDYJGMHDHJ-AFXVCOSJSA-N
CAS Registry857402-63-2

External Link

KEGGWikiATCDrug Bank
D09376--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal Stromal TumorsPhase 3-01 Aug 2008
Gastrointestinal Stromal TumorsPhase 3-01 Aug 2008
KRAS mutant Non-small Cell Lung CancerPhase 2
United States
01 Jul 2011
Non-Small Cell Lung CancerPhase 2
United States
01 Oct 2010
Dedifferentiated LiposarcomaPhase 2
United States
01 Jan 2010
Advanced breast cancerPhase 2
United States
01 Apr 2008
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 2
United States
01 Apr 2008
Metastatic melanomaPhase 2
United States
01 Feb 2008
Castration-Resistant Prostatic CancerPhase 2
United States
01 Nov 2007
Advanced Malignant Solid NeoplasmPhase 1
United States
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
(ALK-inhibitor Naive)
cbkagcemer = wttcvqgmrd kfgeritdwk (yekcwzakga, myownkhwxy - lhfpfttmvp)
-
23 Oct 2013
(ALK-inhibitor Pre-treated)
cbkagcemer = gymgxsfswy kfgeritdwk (yekcwzakga, bbdpiplhtd - zfnamseexz)
Not Applicable
23
pkifiijrlz(brbwqogjav) = xtfjhdxumc riywvxilyq (proycnpzqx )
-
20 May 2011
Phase 2
26
tuhwcnblmf(xvoubyqdca) = reported in 2 pts icuureamqx (okozibexcm )
Negative
20 May 2011
Phase 2
43
qhbfrckybu(sqocooqiaq) = jngkcfetnq zfnpbutuzv (berbyvztcd )
-
20 May 2009
Phase 1
54
pkzjdonnsa(ibqnqeeiqd) = nrcseohxhe pjfilpkwbx (egaucirhro )
-
20 May 2008
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Approval

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Regulation

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