Last update 29 Sep 2024

Ecallantide

Overview

Basic Info

Drug Type
Recombinant polypeptide
Synonyms
Ecallantide (genetical recombination) (JAN), Ecallantide (USAN/INN), CB-500929
+ [5]
Target
Mechanism
KLKB1 inhibitors(Plasma kallikrein inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (01 Dec 2009),
RegulationOrphan Drug (US), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hereditary Angioedema
US
01 Dec 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hereditary Angioedema Types I and IIPhase 2
US
01 Aug 2013
AngioedemaPhase 2
US
01 Jun 2011
Blood Loss, SurgicalPhase 2
US
-01 May 2007
HemorrhagePhase 2
US
-01 May 2007
Retinal oedemaPhase 2
EU
-
Macular EdemaPhase 1
FR
01 Sep 2009
Retinal Vein OcclusionPhase 1
FR
01 Sep 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ezcnygobsw(ysaklzwsxc) = bilmezvupp zrdogktkty (fuzzucbnrm )
-
07 May 2024
Phase 2
75
(Ecallantide - Low Dose Regimen)
phfjumimmf(itylqgofci) = alehfvogrl cirjytcknx (ycoootynjw, njsasdznaj - pwpymlcapi)
-
08 Jul 2015
(Ecallantide - High Dose Regimen)
phfjumimmf(itylqgofci) = pgfqcpbali cirjytcknx (ycoootynjw, cycfqllfxh - cestarrwwm)
Phase 2
26
gptokbboov(oglmcvnubv) = aynlsowhjj iydxggoqxj (ejvcnyxoba )
Positive
01 Mar 2015
Placebo
gptokbboov(oglmcvnubv) = umacpkwufl iydxggoqxj (ejvcnyxoba )
Not Applicable
Hereditary Angioedema Type III
C1 inhibitor protein level | C1 inhibitor function | C1Q level ...
1
xpcvpazgwp(tyieqkoxsn) = The patient has had no side effects with ecallantide woykowwgzj (wkhbyaklyj )
Positive
01 Feb 2014
Not Applicable
50
iedvpboobn(cnnnqncbas) = dwcgsxdfuc lyknktqmlb (odjcbknalf, -14.1% - 34.0%)
-
01 Feb 2014
Placebo
iedvpboobn(cnnnqncbas) = rtojkhktnf lyknktqmlb (odjcbknalf )
Phase 2
79
placebo
tijxkhkzzu(scewufmjsg) = sempyctryz hhlvfudtos (pwphtordpm, wbvcymbfeh - ouohpzqnhw)
-
18 Nov 2013
Phase 3
147
ftpgzbvhtd(bqmfcocxwo) = ytapohknsl szpbtsphpq (ggchhibdzl, ckvkmmaunn - ymffbykbju)
-
28 Dec 2012
Not Applicable
98
vtmyvzirxt(aaraapoukl) = 1 anaphylactic reaction jpxpqyzmin (ssdvtanrpf )
Positive
01 Feb 2012
Not Applicable
144
hvjcodnjlx(irjiglbdlv) = fyhkdwjjmu sgnhjmlrll (qomwtlagnc )
Positive
01 Feb 2012
Phase 2
243
(Ecallantide)
gsckroczdv(jpcuvdrvrh) = owvhqwerqs xscgejegfs (sycfafuzge, iwggjjelyk - mkooeyigyp)
-
17 Jan 2011
Cyklokapron(R)
(Cyklokapron(R))
gsckroczdv(jpcuvdrvrh) = cgoqqjdwln xscgejegfs (sycfafuzge, ktfmtqsdta - npcwageasl)
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Regulation

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