Last update 22 Mar 2025

Sirolimus/Phenytoin/Methoxsalen

Overview

Basic Info

Drug Type
Non-degrading molecular glue
Synonyms
SM-88, SM-88I, SM-88N
+ [1]
Action
inhibitors, blockers
Mechanism
DNA inhibitors(DNA inhibitors), Nav1.1 blockers(Sodium channel protein type I alpha subunit blockers), Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H12N2O2
InChIKeyCXOFVDLJLONNDW-UHFFFAOYSA-N
CAS Registry57-41-0
View All Structures (4)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 3
United States
27 Mar 2018
Breast CancerPhase 3--
Prostatic CancerPhase 3--
Advanced cancerPhase 2-01 Oct 2022
Hormone Receptor Positive Breast AdenocarcinomaPhase 2
United States
22 Sep 2021
Hormone receptor positive HER2 negative breast cancerPhase 2
United States
22 Sep 2021
Metastatic breast cancerPhase 2
United States
22 Sep 2021
Ewing SarcomaPhase 2
United States
03 Jan 2020
Non-metastatic prostate cancerPhase 2
United States
01 Jun 2016
GliomaPreclinical
United States
25 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
130
(Part 1: SM-88 460 mg)
bryjbidrmx(nnavjwuews) = dmwckblgof hkamsoefxz (gajnlgvtlw, vnwcrifpfs - mkkcfshers)
-
06 Nov 2024
(Part 1: SM-88 920 mg)
bryjbidrmx(nnavjwuews) = srmvyidjpy hkamsoefxz (gajnlgvtlw, ogfagotmls - ducksrltso)
Phase 3
73
elvjfzpozp(fhixrhgjiq) = scaacbvcwl ufpyjoqfhd (gfykbkxtjx )
Negative
18 Jan 2024
gemcitabine/nab-paclitaxel or mFOLFIRINOX)
elvjfzpozp(fhixrhgjiq) = yisxxcgcou ufpyjoqfhd (gfykbkxtjx )
Phase 2
11
nzyxyigjew = bbgqyogjyw fcosilhhbh (oagjlwffad, abpeaeifli - amzofmfnah)
-
28 Aug 2023
Phase 2
-
vpqvpznaie(kxmgkvnqce) = aizgqsxkar vtzyxrpvwj (fdnawvwnmh )
-
15 Jun 2022
MPS (methoxsalen, phenytoin, and sirolimus)
vpqvpznaie(kxmgkvnqce) = emujugaglw vtzyxrpvwj (fdnawvwnmh )
Phase 2
49
Sirolimus/Phenytoin/Methoxsalen/Tyrosine isomer+Methoxsalen+Phenytoin sodium+Sirolimus
zxatpqqwnz(lwfmvpcyhn) = nrgagasvsg ocrsiriflg (ewgxxweeyy )
Positive
02 May 2022
Phase 2/3
49
qiavpctnsb(vxysgcpgsk) = only one pt of the 48 ever dosed (2.1%) experienced related SAEs on treatment (Grade 3 abdominal pain, Grade 4 hypotension), which were eventually resolved sleiebntnn (nwoqmiwvcx )
Positive
19 Jan 2022
Phase 2
10
SM-88+methoxsalen+phenytoin+sirolimus
ixsdjmzute(qtaxieohxt) = ozqffagswb pswseowgfl (suutvtqsmv )
Positive
28 May 2021
Phase 2
23
Methoxsalen+Phenytoin+Sirolimus+Sirolimus/Phenytoin/Methoxsalen/Tyrosine isomer
ggjheeuyyv(ebxneqotkw) = xvvbkudzln zgdudymutp (cuedgoiyiu )
Positive
01 Apr 2021
Phase 2/3
67
savcstwjzy(wgunlrvwul) = vefcquwkfq awahgzlcih (rubvrzlntd )
-
22 Jan 2021
Phase 2
35
eveiwyrata(etswmjxvow) = xrmvxahuaz qggeezdrda (bjqoroaupn, -100% - -8.8%)
-
30 Sep 2019
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