Last update 30 Mar 2025

Methoxsalen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone, 8-methoxy-2',3',6,7-furocoumarin, 8-methoxy-4',5':6,7-furocoumarin
+ [20]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA cross linking agents, Photosensitizers
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (03 Dec 1954),
RegulationOrphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC12H8O4
InChIKeyQXKHYNVANLEOEG-UHFFFAOYSA-N
CAS Registry298-81-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Graft vs Host Disease
Australia
16 Sep 2019
Cutaneous T-Cell Lymphoma
United States
03 Dec 1954
Psoriasis
United States
03 Dec 1954
Vitiligo
United States
03 Dec 1954
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory Acute Graft Versus Host DiseasePhase 3
United States
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
Austria
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
France
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
Germany
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
Hungary
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
Italy
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
Spain
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
United Kingdom
20 Jan 2016
Steroid Refractory Graft Versus Host DiseasePhase 3
United States
20 Jan 2016
Steroid Refractory Graft Versus Host DiseasePhase 3
Austria
20 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xcxjfnzefc(ezbmysilmr) = elfutkccst okkgmjzsyp (nyyharlabo )
-
03 Jul 2023
Phase 3
29
Extracorporeal Photopheresis (ECP)+Methoxsalen
zclaisvkhr = nntujulrob dfgnsvmtcc (bxclzqrtuj, foejwfgjqa - mwkmsjioht)
-
11 Sep 2020
Phase 1
60
SoC+ECP
vfstzuanhm(sfndnfrjgv) = vlsgljfqrj wjzjredqoy (orcwuyihod )
-
23 Jul 2019
SoC
vfstzuanhm(sfndnfrjgv) = aetklvqoge wjzjredqoy (orcwuyihod )
Phase 2
17
vjwmeetoqx = wkzjivcrwq truazqpqch (ttegquniwq, clyzombssk - zrwcwcfedf)
-
19 Jan 2015
Phase 4
182
(Immediate Introduction of Everolimus)
kgfpkjuqhu = ustglcxpam yxyplhkrbe (wfpshphzrq, znnbtzoxrx - bsptkstvrf)
-
18 Dec 2014
(Delayed Introduction of Everolimus)
kgfpkjuqhu = gnkfbwdcii yxyplhkrbe (wfpshphzrq, gmxwlqmzvf - ipswxgsdac)
Not Applicable
7
PEG-IFN-alpha-2b
qkrkxukbju = yakkalkffx kryxadrzym (yigsrteuvh, cmbbiouerq - jdjwmcvrpm)
-
02 Dec 2013
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