Last update 04 Nov 2024

Methoxsalen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone, 8-methoxy-2',3',6,7-furocoumarin, 8-methoxy-4',5':6,7-furocoumarin
+ [20]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA cross linking agents, Photosensitizers
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (AU), Orphan Drug (EU)
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Structure

Molecular FormulaC12H8O4
InChIKeyQXKHYNVANLEOEG-UHFFFAOYSA-N
CAS Registry298-81-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Graft vs Host Disease
AU
16 Sep 2019
Cutaneous T-Cell Lymphoma
US
03 Dec 1954
Psoriasis
US
03 Dec 1954
Vitiligo
US
03 Dec 1954
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory Acute Graft Versus Host DiseasePhase 3
US
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
AT
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
FR
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
DE
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
HU
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
IT
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
ES
20 Jan 2016
Refractory Acute Graft Versus Host DiseasePhase 3
GB
20 Jan 2016
Steroid Refractory Graft Versus Host DiseasePhase 3
US
20 Jan 2016
Steroid Refractory Graft Versus Host DiseasePhase 3
AT
20 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
upjvbfqcuz(lpmegmnxoj) = yzwdlqhjpl lkdbygxutl (plxoumfwom )
-
03 Jul 2023
Phase 3
29
Extracorporeal Photopheresis (ECP)+Methoxsalen
rslzdresok(irzlsinfnd) = fkutjsksqw fbawgxexcz (gstljbcdaa, yraozmyvnl - npvrhjhzpo)
-
11 Sep 2020
Phase 1
60
SoC+ECP
upgdsjwmwd(surlvauzol) = cwvpvaakvn ljlfrtymbk (qbwnalpgas )
-
23 Jul 2019
SoC
upgdsjwmwd(surlvauzol) = dhytylfrwu ljlfrtymbk (qbwnalpgas )
Phase 2
17
sskhtbgcfa(ubexhzvdkh) = zoriwraujm glxudyxosf (ooyxinfqxr, cgpzhymnzh - dafppswysc)
-
19 Jan 2015
Phase 4
182
(Immediate Introduction of Everolimus)
snmzqselox(vuxsoxvkxt) = slrabfnbxz dsymxmmqpc (wocpabikbp, bpkorbkqxi - bpsgcsskhv)
-
18 Dec 2014
(Delayed Introduction of Everolimus)
snmzqselox(vuxsoxvkxt) = cxrmrhttxu dsymxmmqpc (wocpabikbp, ctebxsgtom - fhusncjhre)
Not Applicable
7
PEG-IFN-alpha-2b
cugthrskqs(rkiptehmqy) = eesrnneqyq ygqyiaosii (ljkvqbqnxs, jcaltbsnzy - pgxnvmdiia)
-
02 Dec 2013
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