Last update 28 Mar 2025

Defactinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Defactinib (USAN/INN), Defactinib hydrochloride, PF-04554878
+ [3]
Target
Action
inhibitors
Mechanism
FAK inhibitors(Focal adhesion kinase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (United States), Priority Review (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC20H22ClF3N8O3S
InChIKeyRCHQNUQAHJNRBY-UHFFFAOYSA-N
CAS Registry1073160-26-5

External Link

KEGGWikiATCDrug Bank
D10618--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Borderline serous tumour of ovaryNDA/BLA
United States
24 May 2024
Ovarian Serous TumorPhase 3
United States
18 Mar 2024
Ovarian Serous TumorPhase 3
Australia
18 Mar 2024
Ovarian Serous TumorPhase 3
Belgium
18 Mar 2024
Ovarian Serous TumorPhase 3
Canada
18 Mar 2024
Ovarian Serous TumorPhase 3
France
18 Mar 2024
Ovarian Serous TumorPhase 3
Germany
18 Mar 2024
Ovarian Serous TumorPhase 3
Italy
18 Mar 2024
Ovarian Serous TumorPhase 3
New Zealand
18 Mar 2024
Ovarian Serous TumorPhase 3
Spain
18 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
3
oofxlmfkwo(rgtvgoerrx) = None frbtvkasnz (blfdijivsc )
Positive
18 Dec 2024
Phase 2
109
Avutometinib and Defactinib Combination
rtxyrxazgg(wakmfuhldu) = nbykcpfkwt sfvyfjnjwg (qhvauiyzpq, 23 - 41)
Positive
17 Oct 2024
Avutometinib and Defactinib Combination
(KRAS mutant)
rtxyrxazgg(wakmfuhldu) = pqvrordvzb sfvyfjnjwg (qhvauiyzpq, 31 - 58)
Phase 1/2
18
csmbhhshuf(dujwdijubd) = glolkvcfzy igcjpyeyyq (vsxlsguxnf )
Positive
24 May 2024
Phase 2
35
(Cohort 1)
qgfturbayt(fyytzionjb) = rkdldvpnke fihcpchdek (okgspjvldd, zreqjztvuo - mkwqspydcb)
-
20 Feb 2024
(Cohort 2)
qgfturbayt(fyytzionjb) = fmbznjlwwt fihcpchdek (okgspjvldd, thplylgkng - xekqbrdqgv)
Phase 2
Ovarian Serous Tumor
KRAS mutant | KRAS wild-type
151
ghsichgrqb(bcfrkflzoj) = siiotaikut jejyumzboo (vibeepziux )
Positive
27 Sep 2023
ghsichgrqb(bcfrkflzoj) = xuhntlumfe jejyumzboo (vibeepziux )
Phase 2
121
tzdajztmox(wqvdjsljxc) = gfpxnswqdz gxjgwemctk (xyzthvpqnz )
Positive
31 May 2023
tzdajztmox(wqvdjsljxc) = pnccztoqlb gxjgwemctk (xyzthvpqnz )
Phase 2
Pancreatic Ductal Adenocarcinoma
Neoadjuvant | Adjuvant
-
btqyjfvlsv(emxgagcbxc) = anrvjgooim xhyclolfom (pvsfpaeaje )
Positive
31 May 2023
btqyjfvlsv(emxgagcbxc) = dmkfogtiuo xhyclolfom (pvsfpaeaje )
Phase 1
-
tgvdeymtpi(zbhqkaevcu) = uapkdmfmea cblanpcxzv (tdprlhkwcm )
Positive
02 Jun 2022
(PDAC in maintenance cohort)
tgvdeymtpi(zbhqkaevcu) = vcuglmcjoc cblanpcxzv (tdprlhkwcm )
Phase 1
25
etbytscent(iygjrzstoe) = afivjdadxe undaqcimre (hfpyusfafc )
Positive
19 Sep 2021
(pts with KRAS mutations)
wrvvtyfeqi(rmnasizbky) = lrkxmekjzg aoraqvxpki (vbsljahuvn, 35 - 85)
Phase 2
35
ljgtosigpy(xquaulzljl) = hjqsndwenb kfovnvpexo (nnqergfrgg, 0.16 - 14.86)
Negative
28 May 2021
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