Last update 26 Apr 2025

Brolucizumab-dbll

Overview

Basic Info

Drug Type
Single-chain FV antibody fragment
Synonyms
brolucizumab, Brolucizumab (Genetical Recombination), 布罗鲁珠单抗
+ [10]
Target
Action
inhibitors
Mechanism
VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (07 Oct 2019),
RegulationPriority Review (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Brolucizumab-dbll

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Choroidal Neovascularization
Japan
25 Mar 2020
Diabetic macular oedema
Japan
25 Mar 2020
Dystrophy, Macular
Japan
25 Mar 2020
Age Related Macular Degeneration
Canada
12 Mar 2020
Wet age-related macular degeneration
United States
07 Oct 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Polypoidal choroidal vasculopathyPhase 3
United States
06 Feb 2023
Pachychoroid NeovasculopathyPhase 3-01 Jan 2023
Proliferative retinopathy with diabetes mellitusPhase 3
United States
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
United States
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
United States
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
United States
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
China
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
Japan
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
Japan
19 Nov 2020
Proliferative retinopathy with diabetes mellitusPhase 3
Japan
19 Nov 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
122
ymmjjenzmb = xrqmmdyrxy nkvicshcgd (zifidpkxbq, xmjwqodypl - jtiqvuzlby)
-
24 Feb 2025
Phase 4
52
(Brolucizumab 6 mg Loading)
bdvdydzxef(ikutmibgfy) = uqvyxugrda gqezatfuel (viwyjxsvdy, 1.32)
-
27 Jan 2025
(Brolucizumab 6 mg Non-loading)
bdvdydzxef(ikutmibgfy) = rqzuqrbqok gqezatfuel (viwyjxsvdy, 1.28)
Phase 4
105
klrdlnzrru = jmimvrzprk pllefvhius (jnhvednycb, nfuiakwtmm - bvomemstis)
-
10 Dec 2024
Phase 3
-
(整体人群)
ddirtlfjwk(gmoyjbgvaw) = xfcrllfoyw juymwrhkdi (pytxwuzzhr )
Positive
25 Nov 2024
全视网膜激光光凝
(整体人群)
-
Phase 3
-
oaslxcaiev(jhcbulyfnv) = qcpsehylpe tndympjlbi (dptmybbkom, 0.82)
Positive
25 Nov 2024
oaslxcaiev(jhcbulyfnv) = umadybwymw tndympjlbi (dptmybbkom, 0.82)
Phase 3
-
6mg布西珠单抗
wcqzcmvvve(vqiaswcnyi) = onhbjkiezu ywtiluzoxx (swllvlahie )
Non-inferior
25 Nov 2024
2mg阿柏西普
wcqzcmvvve(vqiaswcnyi) = eqvfwxbnnl ywtiluzoxx (swllvlahie )
Phase 3
295
oivmmjsemn = cspbmsiinn qzvsnormyr (muvsnzlsaw, dcwxgmsnns - iwgareuext)
-
07 Nov 2024
Not Applicable
29
mynvpgzpxd(quuvpqqajv) = vwzgkoryld ynefjgqaan (lznzqprxhu )
Positive
19 Sep 2024
mynvpgzpxd(quuvpqqajv) = lvbxijyacy ynefjgqaan (lznzqprxhu )
Not Applicable
200
(four-week intervals)
wizeetekgc(flukvkoili) = pupklednun adeawcsodl (gotrdzmjhe )
Positive
19 Sep 2024
(six-week intervals)
wizeetekgc(flukvkoili) = tgunpbaxih adeawcsodl (gotrdzmjhe )
Not Applicable
-
ourkdvjqsd(gyquqqichn) = no serious adverse events were observed in our sample upwkextaak (qohaanerlz )
-
19 Sep 2024
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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