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Last update 03 Mar 2026
Sosimerasib
Last update 03 Mar 2026
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms 硫酸索美来昔, HBI-2438, HBI2438 + [5] |
Target |
Action inhibitors |
Mechanism KRAS G12C inhibitors(GTPase KRas G12C inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date China (25 Feb 2026), |
RegulationBreakthrough Therapy (China), Conditional marketing approval (China), Priority Review (China) |
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Related
8
Clinical Trials associated with SosimerasibNCT07242274
A Multicenter, Randomized, Open-Label, Phase 3 Study Evaluating the Efficacy and Safety of JMKX001899 Versus Docetaxel in Previously Treated Patients With KRAS G12C-Mutant Advanced or Metastatic Non-Small Cell Lung Cancer
NCT06946927
A Phase Ib, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of JMKX001899 in Combination With Other Therapies in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With KRAS G12C Mutation.
NCT06473948
A Phase 1, Single Center, Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study to Evaluate the Effect of JMKX001899 on the QTc Interval in Healthy Subjects
100 Clinical Results associated with Sosimerasib
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100 Translational Medicine associated with Sosimerasib
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100 Patents (Medical) associated with Sosimerasib
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100 Deals associated with Sosimerasib
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R&D Status
Approved
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| KRAS G12C mutant Non-small Cell Lung Cancer | China | 25 Feb 2026 |
Developing
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| KRAS G12C mutation Solid Tumors | Phase 2 | China | 12 May 2022 | |
| Locally Advanced Lung Non-Small Cell Carcinoma | Phase 1 | China | 06 Jun 2025 | |
| Solid tumor | Phase 1 | - | 01 Apr 2024 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | United States | 01 Aug 2022 | |
| Colonic Cancer | Phase 1 | United States | 01 Aug 2022 | |
| Non-Small Cell Lung Cancer | Phase 1 | United States | 01 Aug 2022 | |
| Pancreatic Cancer | Phase 1 | United States | 01 Aug 2022 |
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