JMKX-001899

To evaluate the effect of JMKX001899 tablets on the QTc interval after a single oral administration in healthy adult subjects

Main purpose 1) To quantitatively analyze the total radioactivity in the excreta of male healthy subjects after a single oral administration of [14C]JMKX001899, and obtain the total recovery rate of human radioactivity and the main excretion pathway; 2) To quantitatively analyze the total radioactivity in whole blood and plasma of male healthy subjects after a single oral administration of [14C]JMKX001899, obtain the pharmacokinetic parameters of total radioactivity in plasma, and investigate the distribution of total radioactivity in whole blood and plasma; 3) To quantitatively analyze the radioactive metabolite profiles in human plasma, urine and feces of male healthy subjects after a single oral administration of [14C]JMKX001899, identify the main metabolites, and determine the metabolic pathways and elimination pathways of JMKX001899 in the human body. Secondary purpose 1) To quantitatively analyze the concentrations of JMKX001899 and metabolite M8 or other metabolites (if applicable) in plasma using a validated LC-MS/MS method, and obtain the pharmacokinetic parameters of JMKX001899 and metabolite M8 or other metabolites (if applicable) in plasma. 2) Obtain pharmacokinetic parameters of total radioactivity in whole blood (if applicable). 3) Observe the safety of [14C]JMKX001899 after a single oral administration in healthy male subjects.