Delving into the Latest Updates on Zhejiang Hangyu Pharmaceutical Co., Ltd. with Synapse

Overview

Tags

Urogenital Diseases

Endocrinology and Metabolic Disease

Neoplasms

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	3
Neoplasms	3
Infectious Diseases	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	7

Top 5 Target	Count

KRAS G12C(GTPase KRas G12C)	1

主要目的：评价JMKX003801在健康成年受试者中单次和多次静脉输注给药剂量递增的安全性和耐受性。次要目的评价JMKX003801在健康成年受试者中单次和多次静脉输注给药的PK特征。评估不同剂量JMKX003801单次给药后对健康成年受试者QTc的影响。初步探索JMKX003801在健康成年受试者的代谢和排泄情况。

[Translation]

Primary objective: To evaluate the safety and tolerability of single and multiple intravenous infusions of JMKX003801 in healthy adult subjects. Secondary objective To evaluate the PK characteristics of single and multiple intravenous infusions of JMKX003801 in healthy adult subjects. To evaluate the effects of single administration of different doses of JMKX003801 on QTc in healthy adult subjects. To preliminarily explore the metabolism and excretion of JMKX003801 in healthy adult subjects.

Start Date14 Aug 2024

Sponsor / Collaborator

Zhejiang Hangyu Pharmaceutical Co., Ltd.

100 Clinical Results associated with Zhejiang Hangyu Pharmaceutical Co., Ltd.

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0 Patents (Medical) associated with Zhejiang Hangyu Pharmaceutical Co., Ltd.

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1

Literatures (Medical) associated with Zhejiang Hangyu Pharmaceutical Co., Ltd.

Huagong Sheji Tongxun

Study on the synthesis of the parent structure of flavanone

Author: Guo, Weiwei ; Zhu, Liang ; Guo, Zhichao ; Xia, Jie

The synthesis method of the parent structure of flavanone involves the selection of different starting materials and specific synthesis steps, such as aldol condensation and catalytic cyclization under weak alk. conditions.By comparing different starting materials and optimizing synthesis methods, an efficient and high-yield synthesis method for the parent structure of flavanone can be obtained, providing important reference and guidance for related research.This article reviews the literature on the synthesis of flavanone precursor structures and summarizes the synthesis methods of flavanone.Using benzaldehyde and ortho hydroxyacetophenone as starting materials, combined with exptl. conditions, the parent structure of flavanone was successfully synthesized through steps such as aldol condensation and catalytic cyclization under weak alk. conditions.This study provides a feasible method for the synthesis of flavanones and is expected to provide new ideas for research in related fields.

100 Deals associated with Zhejiang Hangyu Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Zhejiang Hangyu Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

IND Approval

3

Phase 1 Clinical

Phase 2 Clinical

2

1

Phase 3 Clinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

JMKX-001899 ( KRAS G12C )	KRAS G12C mutant Non-small Cell Lung Cancer More	Phase 3
JMKX-003142	Edema More	Phase 2
JMKX-003002	Hyperphosphatemia More	Phase 2
JMKX-000197	Malignant Pleural Effusion More	Phase 1
JMKX-003801	Complicated urinary tract infection More	Phase 1