Delving into the Latest Updates on AstraZeneca Pty Ltd. with Synapse

Overview

Tags

Other Diseases

Endocrinology and Metabolic Disease

Neoplasms

Small molecule drug

Monoclonal antibody

Prophylactic vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	8
Neoplasms	7
Nervous System Diseases	6
Infectious Diseases	6
Hemic and Lymphatic Diseases	5
Immune System Diseases	5

Top 5 Drug Type	Count

Small molecule drug	10
Monoclonal antibody	4
Antibody drug conjugate (ADC)	1
Recombinant vector vaccine	1
Prophylactic vaccine	1

Top 5 Target	Count

SARS-CoV-2 S protein	3
BTK(Tyrosine-protein kinase BTK)	1
Proton pump	1
AT1R(Angiotensin II Receptor Type 1)	1
Akt-1 x Akt-2 x Akt-3	1

Twenty seven adults and 20 children with previously diagnosed stable asthma, using a salbutamol pressurized metered dose inhaler (P-MDI) and living in Cairns, Townsville and Southport, Queensland, Australia participated in a randomized, open-label cross-over comparison of terbutaline administered via Turbuhaler and salbutamol administered via P-MDI. The aim of the study was to compare the clinical effectiveness and patient acceptance of the two treatments in hot, humid regions. Terbutaline was administered via Turbuhaler and salbutamol via P-MDI on at least two occasions per day during each four week treatment period. Spirometry was performed at the start of the study, after the two week run-in and at the end of each treatment period. Patients used diary cards to record morning and evening peak expiratory flows, daily symptom scores and daily intake of beta 2 agonist medication. At the end of the study, patients answered a treatment preference question. Forty six patients completed the study. No statistically significant differences were observed between the two treatments in peak expiratory flow, change in morning peak expiratory flow pre- and post-beta-agonist, daily symptom scores, diurnal variability and spirometry. Forty four percent of patients preferred the terbutaline Turbuhaler and 39% preferred salbutamol P-MDI. Both agents were similarly tolerated. Terbutaline delivered by Turbuhaler is as clinically effective as salbutamol delivered by P-MDI in patients with asthma living in hot, humid regions.

100 Deals associated with AstraZeneca Pty Ltd.

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100 Translational Medicine associated with AstraZeneca Pty Ltd.

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

NDA/BLA

1

16

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Candesartan Cilexetil ( AT1R )	Heart Failure More	Approved
Tremelimumab ( CTLA4 )	Unresectable Hepatocellular Carcinoma More	Approved
COVID-19 Vaccine (ChAdOx1-S [recombinant])(AstraZeneca Plc) ( SARS-CoV-2 S protein )	COVID-19 More	Approved
Cilgavimab/Tixagevimab ( SARS-CoV-2 S protein )	COVID-19 More	Approved
Andexanet alfa ( factor Xa )	Hemorrhage More	Approved