Last update 21 Nov 2024

MTL-CEBPA

Overview

Basic Info

Drug Type
saRNAs
Synonyms
MTL CEBPA
Target
Mechanism
CEBPA stimulants(CCAAT enhancer binding protein alpha stimulants)
Inactive Indication
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Hepatocellular CarcinomaPhase 2
US
01 Jan 2022
Advanced Hepatocellular CarcinomaPhase 2
SG
01 Jan 2022
Hepatitis BPhase 2
US
01 Jan 2022
Hepatitis BPhase 2
SG
01 Jan 2022
Hepatitis CPhase 2
SG
01 Jan 2022
Hepatitis CPhase 2
US
01 Jan 2022
Hepatocellular CarcinomaPhase 1
TW
01 Mar 2016
Liver CancerPhase 1--
Liver CancerPhase 1--
Liver CancerPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
50
pembrolizumab+MTL-CEBPA
(dose escalation)
(guvqlbojhf) = rhsvanaigc wnzdyhqeyh (rkpgxqyagq )
Positive
12 Nov 2022
pembrolizumab+MTL-CEBPA
(dose expansion)
(guvqlbojhf) = vwirknawcc wnzdyhqeyh (rkpgxqyagq )
Phase 1
10
MTL-CEBPA+pembrolizumab
(emynoyreat) = 2AEs in 1 pt only were grade 3 (ALT and AST increases) zritoypuiy (pblzbvnkwq )
Positive
11 Nov 2021
Phase 1
38
(juihyvlhus) = jxjkvtulzh fhrnapkrof (eyoelkxwfl )
Positive
01 Aug 2020
Phase 1
19
(uibxathwzt) = one patient having an ongoing PR for 18 months associated with 73% decrease in tumour volume and reduction in IL-6, NF-κB and IFN-γ iqjuhdclvq (wmwszgqhtg )
Positive
01 Jun 2018
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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