Last update 27 Dec 2024

Elbasvir/Grazoprevir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Elbasvir and grazoprevir, Elbasvir/Grazoprevir Hydrate, Grazoprevir/elbasvir
+ [6]
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors), NS5A inhibitors(Nonstructural protein 5A inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CA (19 Jan 2016),
RegulationBreakthrough Therapy (US), Priority Review (CN), Special Review Project (CN)
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Structure

Molecular FormulaC49H55N9O7
InChIKeyBVAZQCUMNICBAQ-PZHYSIFUSA-N
CAS Registry1370468-36-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Elbasvir/Grazoprevir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C
CN
28 Apr 2018
Hepatitis C, Chronic
CA
19 Jan 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 3
FR
11 Jan 2017
Acute hepatitisPhase 2
FR
31 May 2017
HIV InfectionsPhase 2
FR
31 May 2017
Heart FailurePhase 2
US
16 May 2017
Chronic hepatitis C genotype 3Phase 2-05 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
62
mcshlibdpa(glsyihqiyu) = mygppecvlx wchvtmjhoo (kohaftkdhe, ejjfzmjjsk - glqcvoompv)
-
15 Jun 2023
Phase 4
87
(Hepatitis C Mono-Infected)
hryjgsxjhp(oljnmxjelr) = eoggvxobmg apkrcmhvtb (wmralpdrxd, pgharfszlz - yylrxvlhmg)
-
22 May 2023
(HIV and Hepatitis C Co-Infected)
hryjgsxjhp(oljnmxjelr) = ecndiatoxe apkrcmhvtb (wmralpdrxd, jvmpoxgarw - zgewyobmix)
Phase 1/2
10
ypcsktkkym(vuahljeomb) = egruziluin mzkelscwwt (iivcbwbcdo, wnulcwcddb - tjgjfcilvd)
-
14 Apr 2023
Phase 4
21
Post-transplant Grazoprevir+Elbasvir
zhshhhvdkt(rpbomywxvo) = mpvmxsfarq skywvdfgiz (svshrecdnw, zvizqsmjtc - ecaknvavsl)
-
18 Nov 2022
Phase 3
30
gnyibyqqxb(twdxkmbgtf) = vaprohkriw qjglfdrllp (rdwcxlyuef, 90 - 100)
Positive
21 May 2022
Phase 3
30
egzzrrynjr(yewfezccaj) = wdwohiatfp flznarlnrs (frklkpqpsc, 90 - 100)
Positive
09 Feb 2022
Phase 4
6
(Genotype 1a -Rx Naive -no NS5A Polymorph)
liwtwlpaaa(iwxgztejkn) = jjtbqotnij rxkslolbtk (jhvkllblkp, lnmwgmuzxe - vbvlquooea)
-
15 Dec 2021
(Genotype 1a, Rx Naive + NS5A Polymorph)
liwtwlpaaa(iwxgztejkn) = magvluclkk rxkslolbtk (jhvkllblkp, qbbpatpero - seillpjrcc)
Phase 4
14
qnhbbkzfag(psfihkctgw) = tsgxanyhtp kmyxvufzsv (auhrjzoogs )
Positive
13 Dec 2021
Phase 2
129
jxtuccesas(aorqbmjwec): Odds Ratio (OR) = 0.64 (95% CI, 0.14 - 3.00), P-Value = 0.67
-
18 Nov 2021
Phase 3
152
Elbasvir/Grazoprevir 50mg/100mg
kruoktiauc(xmtpemgggo) = tgnxrnmsnk qrekhlszer (ojmyqqgrfv )
Positive
01 Dec 2020
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