Bacterial DNA gyrase inhibitors, Bacterial top IV inhibitors(Bacterial topoisomerase IV inhibitors), RNAP inhibitors(Bacterial DNA-directed RNA polymerase inhibitors)

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal DiseasesNervous System Diseases+ [2]

Active Indication

Skin and skin structure infectionsProsthetic joint infectionDiabetic foot infection

Inactive Indication

Gram-Positive Bacterial InfectionsHelicobacter pylori infectionHepatic Encephalopathy+ [4]

Originator Organization

Cumbre Pharmaceuticals, Inc.

TenNor Therapeutics Suzhou Ltd.

Active Organization

丹诺医药（苏州）有限公司University of Iowa Pharmaceuticals

TenNor Therapeutics Suzhou Ltd.

+ [1]

Inactive Organization

Cumbre Pharmaceuticals, Inc.

Drug Highest PhasePhase 3

First Approval Date-

RegulationPriority Review (US), Fast Track (US), Orphan Drug (US), Qualified Infectious Disease Product (US), Special Review Project (CN)

Structure

Molecular FormulaC65H81FN6O15

InChIKeyOPZFMLLAJBIKAN-UHFFFAOYSA-N

CAS Registry922717-97-3

Clinical Trials associated with Rifaquizinone

CTR20221320 / CompletedPhase 1

评价注射用TNP-2092单剂给药、多剂连续静脉输注给药在中国健康受试者中的安全性、耐受性和药代动力学特征的单中心、随机、双盲、安慰剂对照、剂量递增I期临床试验

[Translation] A single-center, randomized, double-blind, placebo-controlled, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetic characteristics of single-dose and multiple-dose continuous intravenous infusion of TNP-2092 for injection in healthy Chinese subjects

评价注射用TNP-2092在中国健康受试者中单剂、多剂连续静脉输注给药的安全性和耐受性；评价注射用TNP-2092在中国健康受试者中单剂、多剂连续静脉输注给药的药代动力学特征。

[Translation]

To evaluate the safety and tolerability of TNP-2092 for injection as a single dose or multiple doses of continuous intravenous infusion in healthy Chinese subjects; To evaluate the pharmacokinetic characteristics of TNP-2092 for injection as a single dose or multiple doses of continuous intravenous infusion in healthy Chinese subjects.

Start Date07 Jul 2022

Sponsor / Collaborator

University of Iowa Pharmaceuticals

[+1]

NCT06394518 / CompletedPhase 1

A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants

This is a phase 1, single-center, randomized, double-blind, placebo-controlled, dose-escalation clinical trial of single and multiple intravenous doses of TNP-2092 for injection in healthy Chinese participants.

Start Date07 Jul 2022

Sponsor / Collaborator

TenNor Therapeutics Suzhou Ltd.

NCT05074134 / CompletedPhase 1

An Open Label Phase 1 Study in Healthy Adult Male Subjects to Investigate the Absorption, Metabolism, and Excretion of [14C]-TNP-2092 Following a Single Intravenous Dose Administration

This is an open-label, single dose, Phase 1 study conducted at a single study center in the United States (USA). This study will evaluate the absorption, metabolism and elimination (AME), mass balance, safety and tolerability of a single dose of intravenously administered [14C]-TNP-2092.
Healthy men aged 18 to 55, will be screened, and subjects who meet all eligibility criteria and provide written informed consent will be enrolled into the study within 28 days of Screening.
Subjects will be admitted to the clinical unit on the day prior to dosing (Day -1). Subjects will fast overnight and then given a standard breakfast 30 min prior to dosing.
Six subjects will be enrolled in the study and each will receive a single intravenous (IV) dose of 300 mg/3 μCi [14C]-TNP-2092 administered over 60 minutes (±10 minutes).

Start Date16 Oct 2021

Sponsor / Collaborator

TenNor Therapeutics Suzhou Ltd.

100 Clinical Results associated with Rifaquizinone

100 Translational Medicine associated with Rifaquizinone

100 Patents (Medical) associated with Rifaquizinone

Literatures (Medical) associated with Rifaquizinone

01 May 2022·Current Medicinal ChemistryQ2 · MEDICINE

A Comparative Insight on the Newly Emerging Rifamycins: Rifametane, Rifalazil, TNP-2092 and TNP-2198

Q2 · MEDICINE

Review

Author: Nazli, Adila ; He, Yun ; Xu, Huacheng ; Wang, Zhi-Peng ; He, David L

Abstract::

Rifamycins are considered a milestone for tuberculosis (TB) treatment because of their proficient sterilizing ability. Currently, available TB treatments are complicated and need a long duration, which ultimately leads to failure of patient compliance. Some new rifamycin derivatives, i.e., rifametane, TNP-2092 (rifamycin-quinolizinonehybrid), and TNP-2198 (rifamycin-nitromidazole hybrid) are under clinical trials, which are attempting to overcome the problems associated with TB treatment. The undertaken review is intended to compare the pharmacokinetics, pharmacodynamics and safety profiles of these rifamycins, including rifalazil, another derivative terminated in phase II trials, and already approved rifamycins. The emerging resistance of microbes is an imperative consideration associated with antibiotics. Resistance development potential of microbial strains against rifamycins and an overview of chemistry, as well as structure-activity relationship (SAR) of rifamycins, are briefly described. Moreover, issues associated with rifamycins are discussed as well. We expect that newly emerging rifamycins shall appear as potential tools for TB treatment in the near future.

01 Aug 2020·Future microbiologyQ3 · BIOLOGY

Rifamycin use for treatment of Helicobacter pylori infection: a review of recent data

Q3 · BIOLOGY

Review

Author: Boyanova, Lyudmila ; Markovska, Rumyana ; Kandilarov, Nayden ; Hadzhiyski, Petyo ; Mitov, Ivan

Helicobacter pylori eradication has become increasingly challenging. We focused on recent data about rifamycin resistance and rifamycin-containing regimens. Rifampin (rifampicin) resistance rates were <1–18.8% (often ≤7%), while those to rifabutin were 0–<4%. To detect rifabutin resistance by rifampin, 4 mg/l breakpoint was suggested. Eradication success by rifaximin-based regimens was disappointing (<62%), while that of rifabutin-containing regimens was 54.5–>96%, reaching >81% in four studies. Some newer rifamycin analogs like TNP-2092 need further investigation. Briefly, although rifabutin-based regimens carry a risk of adverse effects or increasing mycobacterial resistance, they may be a rational choice for some multidrug-resistant H. pylori strains and as a third-line eradication therapy. Bismuth addition to rifabutin-based therapy and combined rifabutin-containing capsules (Talicia) are promising treatment options.

01 Jul 2020·Diagnostic microbiology and infectious diseaseQ4 · MEDICINE

In vitro activity of TNP-2092 against periprosthetic joint infection–associated staphylococci

Q4 · MEDICINE

Article

Author: Schmidt-Malan, Suzannah M ; Ma, Zhenkun ; Patel, Robin ; He, Shijie ; Yuan, Ying ; Fisher, Cody R

Staphylococci are the most common causes of periprosthetic joint infection (PJI). TNP-2092 is an investigational hybrid drug composed of rifamycin and quinolizinone pharmacophores conjugated via a covalent linker. We determined minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm bactericidal concentration (MBBC) values of TNP-2092 against 80 PJI-associated Staphylococcus aureus and Staphylococcus epidermidis isolates compared to ciprofloxacin and rifampin alone and in combination, alongside daptomycin and vancomycin. TNP-2092 exhibited the following activity against S. aureus: MIC₅₀/MIC_90, ≤0.0075/0.015 μg/mL; MBC₅₀/MBC₉₀, 0.5/4 μg/mL; and MBBC₅₀/MBBC₉₀, 0.5/2 μg/mL, and the following activity against S. epidermidis: MIC₅₀/MIC₉₀, ≤0.0075/0.015 μg/mL; MBC₅₀/MBC₉₀, 0.015/0.125 μg/mL; and MBBC₅₀/MBBC₉₀, 0.06/0.25 μg/mL. TNP-2092 MIC, MBC, and MBBC values were >8 μg/mL for 1 isolate, while MIC values were ≤0.25 μg/mL and MBC and MBBC values were ≤4 μg/mL for all other isolates. Results of this study show that TNP-2092 has promising in vitro activity against PJI-associated staphylococci.

News (Medical) associated with Rifaquizinone

27 Feb 2024

·www.businesswire.com

Helicobacter Pylori Infection Pipeline Insight Report 2024: Insights About 5+ Companies and 5+ Pipeline Drugs Featuring TenNor Therapeutics, Servatus Biopharmaceuticals, and TenNor Therapeutics - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "Helicobacter Pylori Infection - Pipeline Insight, 2024" clinical trials has been added to ResearchAndMarkets.com's offering. This report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Helicobacter Pylori Infection pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Report Highlights The companies and academics are working to assess challenges and seek opportunities that could influence Helicobacter Pylori Infection R&D. The therapies under development are focused on novel approaches to treat/improve Helicobacter Pylori Infection. Helicobacter Pylori Infection Emerging Drugs Chapters This segment of the Helicobacter Pylori Infection report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases. Helicobacter Pylori Infection Emerging Drugs TNP-2198: TenNor Therapeutics (Suzhou) Limited Rifasutenizole (TNP-2198) is a new molecule entity discovered and developed by TenNor specifically for the treatment of H. pylori infection. Its multi-targeting synergistic mechanism delivers low drug resistance frequencies, maintaining excellent bactericidal activities against H. pylori strains isolated from various regions. Rifasutenizole has the potential to streamline the eradication regimes of H. pylori so as to improve the compliance and enable a seamless connection to the urea breath test (UBT), rendering the possibility of carrying out screening-eradication on large scale. TenNor is currently conducting a multi-center, randomized, double-blind, bismuth-containing quadruple therapy-controlled Phase III study to evaluate the efficacy and safety of Rifasutenizole in the primary treatment of patients with H. pylori infection. SVT1C4610: Servatus Biopharmaceuticals SVT1C4610 is a live biotherapeutic type of drug. Its mechanism include Bacteria replacements, gastrointestinal microbiome modulators. Its main therapeutic area is infectious disease control. Currently, the drug is in phase I stage of its clinical trial for the treatment of H. pylori infection. Major Players in Helicobacter Pylori Infection There are approx. 5+ key companies which are developing the therapies for Helicobacter Pylori Infection. The companies which have their Helicobacter Pylori Infection drug candidates in the most advanced stage, i.e. Phase III include, TenNor Therapeutics (Suzhou) Limited. Helicobacter Pylori Infection: Pipeline Development Activities The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Helicobacter Pylori Infection therapeutic drugs key players involved in developing key drugs. Pipeline Development Activities The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Helicobacter Pylori Infection drugs. Phases Late stage products (Phase III) Mid-stage products (Phase II) Early-stage product (Phase I) along with the details of Pre-clinical and Discovery stage candidates Discontinued & Inactive candidates Route of Administration Products have been categorized under various ROAs such as Oral Intravenous Subcutaneous Parenteral Topical Molecule Type Products have been categorized under various Molecule types such as Recombinant fusion proteins Small molecule Monoclonal antibody Peptide Polymer Gene therapy Product Type Helicobacter Pylori Infection Report Insights Helicobacter Pylori Infection Pipeline Analysis Therapeutic Assessment Unmet Needs Impact of Drugs Helicobacter Pylori Infection Report Assessment Pipeline Product Profiles Therapeutic Assessment Pipeline Assessment Inactive drugs assessment Unmet Needs Key Players TenNor Therapeutics (Suzhou) Limited Servatus Biopharmaceuticals TenNor Therapeutics Inc. Key Products TNP-2198 SVT-1C4610 TNP-2092 For more information about this clinical trials report visit https://www.researchandmarkets.com/r/ck4nzd About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

Phase 3Phase 1Phase 2Gene Therapy

23 Nov 2023

·www.prnewswire.com

Prosthetic Joint Infections Pipeline Research Report 2023: Comprehensive Insights on 5+ Companies and 5 Drugs

DUBLIN, Nov. 23, 2023 /PRNewswire/ -- The "Prosthetic joint infections - Pipeline Insight, 2023" clinical trials has been added to ResearchAndMarkets.com's offering. This report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Prosthetic joint infections pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. "Prosthetic joint infections- Pipeline Insight, 2023" report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Prosthetic joint infections pipeline landscape is provided which includes the disease overview and Prosthetic joint infections treatment guidelines. The assessment part of the report embraces, in depth Prosthetic joint infections commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Prosthetic joint infections collaborations, licensing, mergers and acquisition, funding, designations and other product related details. Report Highlights The companies and academics are working to assess challenges and seek opportunities that could influence Prosthetic joint infections R&D. The therapies under development are focused on novel approaches to treat/improve Prosthetic joint infections. Prosthetic joint infections Emerging Drugs Chapters This segment of the Prosthetic joint infections report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases. Prosthetic joint infections Emerging Drugs TNP 2092: TenNor Therapeutics TNP-2092 is a multi-targeting drug conjugate that exerts antibacterial activity by inhibiting three essential targets in bacterial biofilms: RNA polymerase, DNA gyrase and topoisomerase IV. TNP-2092 has demonstrated strong bactericidal activity, a low frequency for the development of resistance, and an excellent safety profile. The drug is in Phase II clinical developmental studies for the treatment of bacterial infections and skin and soft tissue infections. In January 2020, TenNor Therapeutics received FDA Orphan Drug Designation for TNP-2092 to treat prosthetic joint infections. PLG0206: Peptilogics PLG0206 is an intravenous antibiotic derived from the cationic antibiotic peptide (eCAP) platform. PLG0206 works by targeting and disrupting bacterial membranes leading to the death of bacterial cells. PLG0206 has been granted FDA Orphan Drug Designation and Qualified Infectious Disease Product Designation for the treatment of prosthetic joint infections (PJI). Currently, the drug is in the Phase I stage of its development for the treatment of PJI. Prosthetic joint infections: Therapeutic Assessment This segment of the report provides insights about the different Prosthetic joint infections drugs segregated based on following parameters that define the scope of the report, such as: Major Players in Prosthetic joint infections There are approx. 5+ key companies which are developing the therapies for Prosthetic joint infections. The companies which have their Prosthetic joint infections drug candidates in the most advanced stage, i.e. phase II include, TenNor Therapeutics. Prosthetic joint infections: Pipeline Development Activities The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Prosthetic joint infections therapeutic drugs key players involved in developing key drugs. Pipeline Development Activities The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Prosthetic joint infections drugs. Key Questions Answered How many companies are developing Prosthetic joint infections drugs? How many Prosthetic joint infections drugs are developed by each company? How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Prosthetic joint infections? What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Prosthetic joint infections therapeutics? What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies? What are the clinical studies going on for Prosthetic joint infections and their status? What are the key designations that have been granted to the emerging drugs? Key Players Adaptive Phage Therapeutics TenNor Therapeutics Peptilogics Key Products Bacteriophage TNP 2092 PLG0206 Phases Late stage products (Phase III) Mid-stage products (Phase II) Early-stage product (Phase I) along with the details of Pre-clinical and Discovery stage candidates Discontinued & Inactive candidates Route of Administration Products have been categorized under various ROAs such as Oral Intravenous Subcutaneous Parenteral Topical Molecule Type Products have been categorized under various Molecule types such as Recombinant fusion proteins Small molecule Monoclonal antibody Peptide Polymer Gene therapy Product Type Prosthetic joint infections Report Insights Prosthetic joint infections Pipeline Analysis Therapeutic Assessment Unmet Needs Impact of Drugs Prosthetic joint infections Report Assessment Pipeline Product Profiles Therapeutic Assessment Pipeline Assessment Inactive drugs assessment Unmet Needs For more information about this clinical trials report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

Orphan DrugPhase 2Phase 1Clinical ResultQualified Infectious Disease Product

24 May 2021

·www.globenewswire.com

Acute Bacterial Skin and Skin Structure Infections Pipeline Featuring Plethora of Emerging Drugs, Key Companies

Los Angeles, USA, May 24, 2021 (GLOBE NEWSWIRE) -- Acute Bacterial Skin and Skin Structure Infections Pipeline Featuring Plethora of Emerging Drugs, Key Companies Ceftobiprole Medocaril under Phase III trials is expected to turn out to be the most effective treatment of Acute Bacterial Skin and Skin Structure Infections. DelveInsight’s ‘Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Pipeline Insights’ report offers a detailed picture of the ABSSSI emerging therapies expected to enter the Acute Bacterial Skin and Skin Structure Infections market along with detailed coverage of the pipeline therapies under development in pre-clinical as well as clinical stages of development, partnerships taking place in the domain, recent happenings in space and growth prospects across the Diabetes domain. Some of the key highlights of the ABSSSI Pipeline report: Request for Sample to know more about the therapies that are set to grab maximum patient pool @ ABSSSI Emerging Therapies and Forecast Acute Bacterial Skin and Skin Structure Infection is a bacterial infection of the skin and associated tissues. The FDA defines skin and skin structure infections as an acute bacterial skin and skin structure infection or ABSSSI if the infection is accompanied by redness, edema, and/or induration of a minimum surface area of 75 cm2, accompanied by lymph node enlargement or systemic symptoms such as fever ≥38°C (100.4°F). Some of the most common bacterial pathogens that cause Acute Bacterial Skin and Skin Structure Infections are Streptococcus pyogenes and Staphylococcus aureus, including methicillin-resistant S.aureus. Less common causes include other Streptococcus species, Enterococcus faecalis, or Gram Negative bacteria. The severity of Acute Bacterial Skin and Skin Structure Infections has led to an increasing emphasis on the identification of novel strategies to treat this disease. For more information on emerging drugs, visit Acute Bacterial Skin and Skin Structure Infections Pipeline Analysis ABSSSI Pipeline Drugs Request for Sample to know more @ Acute Bacterial Skin and Skin Structure Infections Pipeline Analysis, Key Companies and Futuristic Trends Acute Bacterial Skin and Skin Structure Infections Drugs and Therapeutic Assessment The ABSSSI Pipeline report presents comprehensive insights into active ABSSSI pipeline assets segmented by Stage, ABSSSI Product Type, Route of Administration, Molecule Type, Target, and Indications of various drugs. By Product Type By Stage By Molecule Type By Route of Administration By Mechanism of Action By Targets By Stage and Route of AdministrationBy Stage and Product Type Reach out for Rich and Deep Market Assessment and Consulting Solutions Scope of the Report Coverage: GlobalKey Players: Basilea Pharmaceutica, TenNor Therapeutics, Innovation Pharmaceuticals, Debiopharm Group, MicuRx Pharmaceuticals, Taxis Pharmaceuticals, Botanix pharmaceuticals, Motif Bio, KBP Biosciences, Atox Bio and others. Key ABSSSI Pipeline Therapies: Ceftobiprole medocaril, TNP-2092, Brilacidin, Afabicin, Contezolid acefosamil, TXA709, Cannabidiol, KBP-7072, Nemonoxacin, AB-103 and others. Reach out @ Acute Bacterial Skin and Skin Structure Infections Pipeline: Novel therapies and emerging technologies Table of Contents Visit to know more of what’s covered @ ABSSSI Emerging Therapies Related ReportsAcute Bacterial Skin And Skin Structure Infections MarketDelveInsight's "Acute Bacterial Skin and Skin Structure Infections - Market Insights, Epidemiology, and Market Forecast-2030" report. Acne Vulgaris MarketDelveInsight's "Acne Vulgaris Market Insights, Epidemiology, and Market Forecast-2030" report. Moderate To Severe Atopic Dermatitis MarketDelveInsight's "Moderate to Severe Atopic Dermatitis (AD) - Market Insights, Epidemiology, and Market Forecast-2030" report. Acral Lentiginous Melanoma MarketDelveInsight's "Acral lentiginous melanoma - Market Insights, Epidemiology, and Market Forecast-2030" report. Androgenetic Alopecia MarketDelveInsight's "Androgenetic Alopecia Market Insights, Epidemiology, and Market Forecast-2030" report. Related Posts ABSSSI Market and Key Treatments Atopic Dermatitis MarketRosacea Pipeline and Therapies Marijuana Clinical TrialsOpiate Withdrawal Cocktail About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing end-to-end comprehensive solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve. For more insights, visit Pharma, Healthcare, and Biotech News

100 Deals associated with Rifaquizinone

External Link

KEGG	Wiki	ATC	Drug Bank
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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Skin and skin structure infections	Phase 3	CN	TenNor Therapeutics Suzhou Ltd.	26 Feb 2022
Irritable bowel syndrome with diarrhea	Phase 2	CN	TenNor Therapeutics Suzhou Ltd.	09 Sep 2021
Hyperammonemia	Phase 2	CN	TenNor Therapeutics Suzhou Ltd.	27 Aug 2020
Liver Cirrhosis	Phase 2	CN	TenNor Therapeutics Suzhou Ltd.	27 Aug 2020
Hepatic Encephalopathy	Phase 2	CN	TenNor Therapeutics Suzhou Ltd.	25 Aug 2020
Gram-Positive Bacterial Infections	Phase 2	US	TenNor Therapeutics Suzhou Ltd.	20 Apr 2019
Skin Diseases, Bacterial	Phase 2	US	TenNor Therapeutics Suzhou Ltd.	20 Apr 2019
Prosthetic joint infection	Phase 1	US	TenNor Therapeutics Suzhou Ltd.	01 Mar 2021
Helicobacter pylori infection	Phase 1	-	TenNor Therapeutics Suzhou Ltd.	07 Nov 2016
Diabetic foot infection	IND Approval	CN	Dan Nuo Yi Yao （ Zhong Shan ） You Xian Gong Si	27 Dec 2023

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT06135675 (CTgov)	Phase 1/2	Hyperammonemia \| Liver Cirrhosis	36	TNP-2092 capsules (TNP-2092 Capsules 100mg Twice Daily(BID))	wvnlupdyjv(ncflztqnhn) = prxkwikmlj ucgmhszvpw (eopctbekzx, uwiqjnuhut - wrwdacfond) View more	-	10 May 2024
				TNP-2092 capsules (TNP-2092 Capsules 300mg BID)	wvnlupdyjv(ncflztqnhn) = byptdbdsjh ucgmhszvpw (eopctbekzx, pnewjvfwbc - hnseofvxop) View more
NCT03964493 (P2_ABSSSI, CTgov)	Phase 2	Skin Diseases, Bacterial \| Gram-Positive Bacterial Infections \| Skin and skin structure infections	120	TNP-2092 (TNP-2092)	bvxfjmgvud(zbnbczbmoo) = rghvlzolib zezpfronih (vgdzlfekdp, vuvzqoswoz - qqdrpcygmo) View more	-	01 Dec 2023
				Vancomycin (Vancomycin)	bvxfjmgvud(zbnbczbmoo) = wibowhpyqg zezpfronih (vgdzlfekdp, avsixlmull - wrculjzlhk) View more
NCT03964493 (P2_ABSSSI, Biospace) Manual	Phase 2	Skin and skin structure infections	-	TNP-2092	bancgptjoo(hdxvkkkvec) = huxqeziajb vnbjvpajfo (jgqhwpqook ) View more	Positive	11 Nov 2019
				vancomycin	bancgptjoo(hdxvkkkvec) = tlrpohwdnv vnbjvpajfo (jgqhwpqook ) View more

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