Last update 21 Nov 2024

Ibrilatazar

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sodium 2-hydroxylinoleate
+ [2]
Target
Mechanism
PPARα/γ agonists(PPAR alpha/gamma agonists)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (EU)
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Structure

Molecular FormulaC18H32O3
InChIKeyAFDSETGKYZMEEA-HZJYTTRNSA-N
CAS Registry57818-44-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 2
EU
30 Jan 2022
Pancreatic CancerPhase 2
EU
30 Jan 2022
Secondary malignant neoplasm of pancreasPhase 2
ES
26 Apr 2021
Squamous non-small cell lung cancerPhase 2
ES
01 Dec 2016
Endometrial CarcinomaPhase 1
CN
29 Oct 2018
Endometrial CarcinomaPhase 1
CN
29 Oct 2018
Endometrial CarcinomaPhase 1
CN
29 Oct 2018
Advanced cancerPhase 1
ES
01 Feb 2014
Advanced Malignant Solid NeoplasmPhase 1
ES
01 Feb 2014
Advanced Endometrial CarcinomaPreclinical
ES
01 Dec 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
51
Ibrilatazar (ABTL0812) + Carboplatin/Paclitaxel
(The phase 1 part)
-
Positive
22 Jul 2024
Ibrilatazar (ABTL0812) + Carboplatin/Paclitaxel
(The phase 2 part)
(wnwudvvltk) = azcqtrcfvv axckokllit (oklyriqdqe )
Phase 2
40
ABTL0812+Paclitaxel+Carboplatin
(jigmnuuswg) = bjbwwirycc ppnlzkwjqh (ywgbtqtghh, 34.2 - 65.9)
Positive
26 May 2023
Not Applicable
22
(bosnpfupfy) = caksexlnxz bxfgvzqyvt (kyudvdnohl, 32.2 - 75.6)
-
29 Jan 2021
Phase 2
42
(fhlrxbkpmy) = ixkelouxxn qxjhixtqdt (heucgqiywv, 46 - 80)
Positive
17 Sep 2020
Phase 1
21
Paclitaxel+Carboplatin+ABTL 0812
(tcnnclaasv) = neutrophil count decreased (43%), nausea (24%), fatigue (19%), anemia, vomiting, dyspepsia, platelet count decreased, arthralgia and neurotoxicity (10% each) hwxuczpjaj (xditrpzmbi )
Positive
01 Jun 2019
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Regulation

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