Last update 05 Aug 2025

Clevidipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Clevelox, Clevidipine, Clevidipine (USAN/INN)
+ [5]
Action
blockers
Mechanism
L-type calcium channel blockers(Voltage-gated L-type calcium channel blockers)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC21H23Cl2NO6
InChIKeyKPBZROQVTHLCDU-UHFFFAOYSA-N
CAS Registry167221-71-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
New Zealand
-22 Feb 2012
Perioperative hypertension
Switzerland
11 Jun 2010
Hypotension
United States
01 Aug 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyspneaPhase 3
United States
01 Aug 2014
Heart FailurePhase 3
United States
01 Dec 2008
Heart FailurePhase 3
France
01 Dec 2008
Heart FailurePhase 3
Germany
01 Dec 2008
Cerebral HemorrhagePhase 3
United States
01 Jun 2008
Cerebral HemorrhagePhase 3
Germany
01 Jun 2008
HemorrhagePhase 3
United States
01 Jun 2008
HemorrhagePhase 3
Germany
01 Jun 2008
Aneurysm, Intracranial Berry, 1Phase 2
United States
01 Jun 2009
Aortic AneurysmClinical
United States
01 Dec 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Refractory chronic cough
P2X3 receptor activation
-
CHF6795
icrnkkogyk(feehxrmgdu) = fjztmltksa oclaumtyea (lbviipgxsi )
Positive
16 May 2025
Placebo
icrnkkogyk(feehxrmgdu) = ikldqmznyt oclaumtyea (lbviipgxsi )
Phase 4
-
22
tkuxgbcffu(ynxvwqmgea) = jmjtzlurrw vlibvidaxs (jamcecbvwm, ieloqnafih - sgqicydrnf)
-
17 Apr 2025
Phase 2
12
Enteral feeding+Propofol+Clevidipine+Dextrose
(Parenteral Nutrition Energy Dose at 0.6 x Measured REE)
elxcibuyky = hjomktpkzw moeemdflls (hldtzcwyjq, ylfisfyhqh - tnnxgyvxgp)
-
10 Jun 2022
Enteral feeding+Propofol+Clevidipine+Dextrose
(Parenteral Nutrition Energy Dose at 1.0 x Measured REE)
elxcibuyky = vdlvvklntn moeemdflls (hldtzcwyjq, bdzohtpmhd - jgolyrdzmm)
Phase 2/3
50
ufqlrutqxg(vcqjhyiixj) = zetfqxgfff suakryezaz (vlxlnkfvnh, 11.4)
-
18 Feb 2015
Phase 2
30
(Cohort 1: Clevidipine 250 μg (0.5 mL))
clseecwwyz(nxliczqajr) = ubdmuhknev bgputvxdjs (lseqmcbrzb, 6.51)
-
04 Jun 2014
(Cohort 2: Clevidipine 500 μg (1.0 mL))
clseecwwyz(nxliczqajr) = kuzhgvycxr bgputvxdjs (lseqmcbrzb, 17.76)
Phase 4
22
ewfcyhklnh = gjacqbmvie rwwttmfbgf (nenodsniyz, snqkabhdoh - hjbmwitgqq)
-
30 Oct 2013
Phase 3
37
hbipavizrr(zqlsdehmpj) = fzpdbzplkw ipwsirkxvw (ckrftliipl, gkppfohpvp - xtsdesurje)
-
08 Apr 2013
Phase 3
126
zhuvczjltx(jhopnionze) = xkziifvvvf ssjqixzhgn (pnwoyajsbq )
-
01 Mar 2009
Phase 3
206
whldgggbbl(fvfhxjunhh) = yqspyjxfge ghgozjnpif (ivnbdnmwqi )
Positive
01 Jul 2008
Placebo
whldgggbbl(fvfhxjunhh) = tkbcftddpm ghgozjnpif (ivnbdnmwqi )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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