This is a double-blind randomized controlled study. The study will last up to 16 weeks from the initial phone screen (it could take up to eight weeks to schedule and complete the initial screening process and schedule the 2 MRI visits). Once subjects have completed the screening process, they will begin the 8-week trial phase. Subjects will be assessed weekly throughout the study for efficacy and tolerability.
The investigators plan to recruit 80 participants with emotional dysregulation (ED) in the treatment arm. In addition, the investigators will aim to recruit 40age-, sex-, and parental-education matched participants without emotional dysregulation, and major psychopathology as Typically Developing (TD) control participants in the control arm.
Upon scheduling the baseline visit, only the emotional dysregulation (ED) participants will be randomized 1:1 to be exposed to NAC or placebo treatment for 8 weeks. Participants will complete baseline and post-treatment (endpoint) brain MRI acquisition. TD participants will complete the same screening and characterization process as the ED group and then will be invited to complete MRI eligibility screening and to be scanned twice, separated by an eight-week interval, but the TD will not complete the NAC treatment or receive a placebo. See Table 1 (Study Schema) for a complete list of characterization measures to be completed by each group.

Start Date01 Jan 2027

Sponsor / Collaborator

The Massachusetts General Hospital

[+1]

NCT07227649

/ Not yet recruitingPhase 2IIT

NAC-REPAIR: N-Acetylcysteine-facilitated Redox-Immune Modulation for Post-surgical Analgesia and Injury Recovery

This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response.
Methods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.

Start Date15 Oct 2026

Sponsor / Collaborator

University of Arizona

[+1]

NCT06260566

/ Not yet recruitingPhase 1IIT

A Phase 1 Trial of Tolerability of Enteral N-Acetylcysteine in Infants

Biliary atresia (BA) is a neonatal liver disease characterized by impaired bile flow and is the most common indication for pediatric liver transplantation. BA can be treated with the Kasai portoenterostomy (KP), a procedure that attempts to restore bile flow and slow disease progression. However, success of the KP procedure is quite variable, and lack of adjuvant medical therapies following KP is a major gap in pediatric hepatology.
This study begins to explore oral N-acetylcysteine (NAC) as a potential medical therapy in BA by determining whether an oral formulation can be given to infants. The primary objective is to determine tolerability of the oral NAC formulation. The primary outcome is tolerating at least 3 out of 4 total doses without emesis. The Bayesian Optimal Interval Design (BOIN) trial design will be used to determine the maximum tolerated dose of oral NAC. Our secondary objective is to assess palatability of the oral NAC formulation by comparing facial expressions when taking oral NAC versus other medications commonly given to cholestatic infants.

Start Date01 Oct 2026

Sponsor / Collaborator

Baylor College of Medicine

[+1]

100 Clinical Results associated with Acetylcysteine

100 Translational Medicine associated with Acetylcysteine

100 Patents (Medical) associated with Acetylcysteine

30,059

Literatures (Medical) associated with Acetylcysteine

31 Dec 2026·DRUG DELIVERY

Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.

Review

Author: O'neill, Allison F ; Huitema, Alwin D R ; Bleyer, Archie ; Bouffet, Eric ; Streefkerk, Nienke ; Masroor, Amirhossein ; Sullivan, Michael ; Fresneau, Brice ; Maibach, Rudolf ; Van Grotel, Martine ; Hoetink, Alexander E ; Rajput, Kaukab M ; Papadakis, Vassilios ; Knight, Kristin ; Brock, Penelope R ; Geller, James I ; Kogner, Per ; Veal, Gareth J ; Ansari, Marc ; Van Den Heuvel-Eibrink, Marry M

Cisplatin-induced hearing loss (CIHL) in pediatric cancer patients is an irreversible and highly prevalent adverse effect with a devastating impact on quality of life. Sodium thiosulfate (STS) has recently been approved for systemic administration as an otoprotective agent in children. However, implementation of systemic STS has its challenges, and there is currently limited evidence to support local STS for children. This review investigates the potential value of locally administered otoprotective agents other than STS with a focus on future pediatric implementation. We conducted a systematic review on the efficacy and safety of locally applied non-STS otoprotective agents in in vivo settings. This included a summary of investigated drug delivery methods and administration routes. We identified 70 preclinical and eight clinical studies. Agents were categorized based on their biological mechanisms: anti-inflammatory, chemical deactivators, calcium blockers, biologicals, and miscellaneous mechanisms. Preclinical studies investigated 45 different agents. Dexamethasone and N-acetylcysteine were identified as efficacious agents recurrently and progressed to clinical trials. Dexamethasone was investigated in three randomized clinical trials (RCTs) and three non-randomized clinical studies and showed statistically significant but not clinically relevant benefit in two trials. N-acetylcysteine was investigated in two clinical trials and one RCT and was minimally effective in the RCT and in one clinical study. Our review did not identify available studies of local alternative otoprotective agents that could reliably replace systemic STS in terms of safety and efficacy for pediatric patients. Further research on the optimal dosage, delivery method, and timing of otoprotective agents is needed.

31 Dec 2026·CNS oncology

Arginine deprivation induces prolonged autophagy activation and ROS-dependent cell death in glioblastoma multiforme

Article

Author: El-Jawhari, Yasmin ; Saad, Rawan ; Sarieddine, Majd ; El-Husseini, Nour ; El-Sibai, Mirvat ; Abi-Habib, Ralph J. ; Shaheen, Maha ; Abdelkhalek, Maya

BACKGROUND:

Arginine deprivation was shown to be selectively cytotoxic to GBM cells with cell death being caspase-independent, non-apoptotic. In this study, we assess the impact of prolonged arginine deprivation on GBM cells, the potential activation of autophagy, the mechanism of its activation, and its impact on cell cytotoxicity.

METHODS:

GBM cell lines A172 and U251 were used in this study and arginine deprivation was induced by a cobalt-substituted, PEGylated human arginase I [HuArgI (Co)-PEG5000].

RESULTS:

Arginine deprivation induced prolonged cytotoxicity up to 120 hours post-treatment. Cytotoxicity persisted despite cells overexpressing ASS-1. Arginine deprivation also induced a marked and sustained activation of autophagy, starting at 24 hours and lasting up to 120 hours post-treatment. Autophagy was shown to induce cell death since its inhibition by chloroquine significantly decreased cytotoxicity, indicating that the extensive activation of autophagy is resulting in cell death of GBM cells. Moreover, ROS was shown to accumulate in treated cells and neutralizing ROS using NAC did not affect the autophagic response but led to a complete reversal of cytotoxicity, demonstrating that death by autophagy is dependent on ROS generation.

CONCLUSION:

Arginine deprivation leads to sustained activation of autophagy and subsequent ROS-dependent cell death in GBM cells.

31 Dec 2026·Journal of the International Society of Sports Nutrition

A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance

Review

Author: Edwards, Sophie ; Cornelisse, Erik ; Prieto-Bellver, Gorka ; Rowland, Angela ; Rowland, Andrew ; Hopkins, Ashley M ; Karapetis, Christos S ; Menz, Bradley ; Wallen, Matthew P

BACKGROUND:

A growing body of evidence supports the use of supplements to enhance cycling performance through both direct and indirect mechanisms.

METHODS:

This review was informed by a structured literature search conducted in PubMed, Scopus and Web of Science for peer-reviewed studies published up to May 2025. Studies were included if they involved human participants, were published in English and evaluated outcomes related to endurance performance, recovery or physiological function.

RESULTS:

Direct enhancement with ergogenic supplements is primarily achieved via modulation of skeletal muscle energy metabolism. During exercise, adenosine triphosphate (ATP) resynthesis is driven by the phosphagen system, glycolysis, oxidative phosphorylation and beta-oxidation, with each system contributing according to the intensity and duration of the effort. Supplements such as beta-alanine, caffeine, carbohydrates, carnitine, creatine monohydrate, dietary nitrates, electrolytes, exogenous ketones, N-acetylcysteine and sodium bicarbonate support these energy systems by improving substrate utilization, buffering capacity, energy availability or resistance to fatigue. In addition to ergogenic supplements that directly enhance performance, medical supplements play an important indirect role by supporting bone health, connective tissue integrity, inflammation management, micronutrient status, muscle repair and gut function. Evidence-based options for cyclists include calcium, cherry juice, collagen, curcumin, iron, multivitamins, omega-3 fatty acids, pickle juice, probiotics, protein, vitamin C, vitamin D and zinc. Each contribute to either improved recovery, immune support or long-term physiological adaptation. Evidence quality varied substantially across supplements, with strongest support for Australian Institute of Sport (AIS) Group A compounds. The integration of physiological testing including assessments of maximal oxygen consumption (VO₂max), lactate threshold, metabolic substrate utilization and blood biomarkers may inform the development of individualized supplementation strategies tailored to training demands and competitive goals.

CONCLUSIONS:

This evidence-informed approach underscores the synergistic relationship between nutrition, training and performance optimization in cycling. Future research should explore personalized nutrition frameworks, interactions between multi-supplement protocols and the molecular mechanisms underpinning adaptation to endurance training and nutritional interventions.

133

News (Medical) associated with Acetylcysteine

01 Jul 2026

·www.apotex.com

Apotex completes previously announced strategic transaction with Cumberland Pharmaceuticals

TORONTO, July 1, 2026 /CNW/ – Apotex Health Corp. ("Apotex") (TSX: APTX), the largest Canadian-based pharmaceutical company, today announced the closing of its previously announced strategic transaction with Cumberland Pharmaceuticals Inc. ("Cumberland"), a U.S. biopharmaceutical company, to integrate Cumberland's U.S. branded businesses into Apotex. With the completion of the strategic transaction, Apotex adds a portfolio of established branded medicines to its U.S. business, expanding its specialty and hospital-focused presence across key therapeutic areas including acute care, oncology, infectious disease, and gastroenterology. "This milestone strengthens our ability to support patients and healthcare providers across the United States," said Jeff Watson, President & CEO of Apotex. "We look forward to integrating these important medicines into our portfolio and expanding access to high-quality treatments." "We are pleased to have completed this strategic transaction with Apotex, which will create more critical mass to better support patient care," said A.J. Kazimi, CEO of Cumberland Pharmaceuticals. The portfolio includes well-established brands, including Kristalose®, Caldolor®, Sancuso®, Vibativ®, Acetadote®, Vaprisol®, and Talicia®, which are prescribed across hospitals, oncology, infectious disease, and gastroenterology settings. About Apotex Apotex is a Canadian-based global health company. We improve everyday access to affordable, innovative medicines and health products for millions of people around the world, with a broad portfolio of generic, biosimilar, and innovative branded pharmaceuticals, and consumer health products. Headquartered in Toronto, with regional offices globally, including in the United States, Mexico, and India, we are the largest Canadian-based pharmaceutical company and a health partner of choice for the Americas for pharmaceutical licensing and product acquisitions. Learn more at www.apotex.com Forward-Looking Statements This press release may contain forward-looking information within the meaning of applicable securities laws, including statements about strengthening Apotex's ability to support patients and healthcare providers across the United States, Apotex integrating the acquired medicines into its portfolio and expanding access to high-quality treatments, and creating critical mass to better support patient care. Statements containing forward-looking information are not historical facts but instead represent management's expectations, estimates and projections regarding future events or circumstances. Forward-looking information is necessarily based on a number of opinions, estimates and assumptions that, while considered by Apotex to be appropriate and reasonable as of the date of this release, are subject to known and unknown risks, uncertainties, assumptions and other factors that may cause actual results to differ materially from those expressed or implied by such forward-looking information. Such risks and uncertainties include, but are not limited to, factors discussed under “Risk Factors” in Apotex's public filings and include risks associated with Apotex being unable to support patients and healthcare providers across the United States, failure to integrate the acquired medicines in Apotex's portfolio, failure to expand access to high-quality treatments and failure to create critical mass to better support patient care. Apotex undertakes no obligation to publicly update or review any forward-looking information, whether as a result of new information, future events or otherwise, except as expressly required under applicable securities laws. About Cumberland Pharmaceuticals Cumberland Pharmaceuticals Inc. is a Nashville-based biopharmaceutical company focused on developing new therapies for rare diseases. The company is advancing a late-stage pipeline of product candidates through a series of late-stage clinical studies. The treatments are being developed across multiple therapeutic areas to address serious patient conditions that represent unmet medical needs. Cumberland's Phase 2 clinical programs are evaluating ifetroban in patients with Duchenne Muscular Dystrophy, Systemic Sclerosis, Idiopathic Pulmonary Fibrosis and Cancer Metastasis. For more information, please visit www.cumberlandpharma.com Media contact: media@apotex.com

Phase 2Acquisition

24 Jun 2026

·www.prnewswire.com

Roamin Cat Should Have Held the Onions

Frisky Feline Poisoned by Discarded Sliders MINNEAPOLIS, June 24, 2026 /PRNewswire/ -- Sometimes a pet is named for his appearance, such as Spot or Red. Others practically name themselves by their behavior. From the moment Michael Nihart saw his new cat investigating the entire house, it was pretty clear that Roamin had his name, and that he likes mischief. "He's like a dog in a cat's body," joked Lisa Nihart, Michael's mom. "He's always getting into trouble and trying to sneak outside." Continue Reading "Cats often have very high curiosity, which in this case could have actually killed him." Post this Roamin found out the hard way how dangerous ingesting onions are for cats. That curious nature, however, can get pets into trouble. "Cats often have very high curiosity, which in this case could have actually killed him," said Dr. Renee Schmid, a senior veterinary toxicologist and director of Veterinary Medicine at Pet Poison Helpline. "Roamin got into the trash and ingested two White Castle™ sliders with diced onion. Although the high fat and salt content can cause gastrointestinal upset, it was the onions that caused us the most concern." In honor of National Onion Day on June 27, the toxicology experts at Pet Poison Helpline want to warn pet lovers that toxic doses of onions by pets can result in oxidative damage to the red blood cells, making the cells more likely to rupture. It can also cause gastroenteritis, resulting in nausea, oral irritation, drooling, abdominal pain, vomiting and diarrhea. With onions, poisoning may have a delayed onset, and clinical signs may not be apparent for several days. Left untreated, it can result in death. "Not only do White Castle sliders have onions on them, but they also have onions in them," Lisa Nihart explained. "Being a veterinary technician, I knew onions were dangerous to cats, so I called Pet Poison Helpline. They recommended I take Roamin to the hospital." Roamin was taken to Wellhaven Pet Health Maple Grove for evaluation and treatment. "Nobody had any idea what to do," Lisa Nihart said. "It's a good thing we already had a case started with Pet Poison Helpline, because the hospital team was able to begin evaluating her immediately. Because I'm a tech, I thought I could monitor and treat him at home." Based on the timing of the ingestion, it was too late to induce vomiting or provide additional decontamination, so an anti-emetic was given, bloodwork was performed and subcutaneous fluids were administered. Nihart decided to take Roamin home and was given antioxidants to administer to help minimize red cell damage and advised to recheck bloodwork every two to three days to evaluate for anemia. Roamin would also need to return the veterinary hospital if he was lethargic, not eating, or had any other abnormal behavior. After several days, Michael noticed that Roamin was still not his normal rambunctious self and had pale coloring to his gums, which could indicate anemia. He insisted that something was wrong, and his mom took the cat back to the hospital for a recheck of his bloodwork and potentially additional treatment. By that time, Roamin's blood cells were showing signs of significant damage. Roamin's red blood cell count was dangerously low, and his bloodwork was consistent with red blood cell damage caused by the toxic components of onions. "We recommended a very aggressive treatment," Dr. Schmid said. "One of our veterinary toxicologists who managed Roamin's case advised to start intravenous fluids, an additional antioxidant and glutathione replacer called N-Acetylcysteine, as well as additional antioxidants. Fortunately for Roamin, he remained stable enough to not need a blood transfusion." Roamin remained in the hospital for several days and continued to have bloodwork monitoring for two weeks to ensure his red blood cells had returned to normal, healthy numbers. While Roamin's exposure had a happy ending, onion poisoning, and any Allium species in general, be challenging to relay the potential severity with pet owners. Many pet foods and products contain onion or garlic to enhance flavoring. When it comes to determining the toxicity of garlic and onions, the dose matters. The amounts added to pet products are well below a dose where poisoning could occur, but that doesn't mean those foods aren't toxic at larger doses. Also, because signs of poisoning often do not develop until several days to a week after the ingestion, many pet owners will assume their pet is out of the woods and may choose not to be more aggressive with their initial care. Unfortunately, this can result in fatal consequences. "I'm really glad Michael is so focused on Roamin," Lisa Nihart added. "He noticed the changes in his behavior and talked me into going back to the hospital. It probably saved Roamin's life." Pet Poison Helpline created Toxin Tails to educate the veterinary community and pet lovers on the many types of poisoning dangers facing pets, both in and out of the home. All the pets highlighted in Toxin Tails have been successfully treated for the poisoning and fully recovered. About Pet Poison Helpline Pet Poison Helpline®, your trusted source for toxicology and pet health advice in times of potential emergency, is available 24 hours, seven days a week for pet owners and veterinary professionals who require assistance treating a potentially poisoned pet. Per incident and subscription service options are available. We are an independent, nationally recognized animal poison control center triple licensed by the Boards of Veterinary Medicine, Medicine and Pharmacy providing unmatched professional leadership and expertise. Our veterinarians and board-certified toxicologists provide treatment advice for all species, including dogs, cats, birds, small mammals, large animals and exotic species. As the most cost-effective option for animal poison control care, Pet Poison Helpline's fee of $89 per incident includes follow-up consultations for the duration of the case. The company also offers pethelpline(SM) and pethelplinePRO(SM) subscription services directly to pet lovers. Based in Minneapolis, Pet Poison Helpline is available in North America by calling 800-213-6680. Additional information, including a chat feature for pet owners, can be found online at . Contact: Curtis Steinhoff Pet Poison Helpline® (602) 300-8466 [email protected] SOURCE Pet Poison Helpline 21% more press release views with Request a Demo

28 May 2026

·www.prnewswire.com

Nevisense detects skin barrier damage by chemicals used in household cleaning products in a new ex-vivo study

STOCKHOLM, May 28, 2026 /PRNewswire/ -- SciBase Holding AB ("SciBase") (STO: SCIB) , a leader in AI-based devices for detection and prevention in dermatology, announced today the publication of a scientific project with the Swiss Institute of Allergy and Asthma Research (SIAF) in Davos, Switzerland. Nevisense and its underlying Electrical Impedance Spectroscopy (EIS) technology were used to show that surfactants in household cleaning products disrupt the human skin barrier. In the study, human ex vivo skin samples were exposed to Sodium dodecyl sulfate (SDS), a surfactant in household cleaning products which is known to impair the barrier. Also, skin that was affected by SDS were treated with N-acetylcysteine (NAC) and nicotinamide (NAM) to promote recovery of skin barrier function. Nevisense was used in the study to detect the changes in the skin barrier and detected that short-term exposure to SDS rapidly disrupts human skin barrier integrity within minutes as well as the effect of NAC and NAM. Skin barrier research is an expanding area in dermatology. Disruption of skin barrier function plays a key role in the development and severity of e.g. contact dermatitis from chemical substances "We are happy to see that Nevisense and EIS-technology continue to provide value in this type of research. This study further strengthens the role of Nevisense as an effective research device and show the potential to become the state-of-the-art research tool within the skin barrier research," said Pia Renaudin, CEO of SciBase. The full results of the study have now been published in the scientific journal Allergy " Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms," - Li - Allergy, DOI: For additional information, please contact: Pia Renaudin, CEO, tel. +46732069802, e-mail: [email protected] Certified Advisor (CA): DNB Carnegie Investment Bank AB (publ) Phone: +46 8 588 68 570, E-mail: [email protected] About SciBase SciBase is a global medical technology company, specializing in early detection and prevention in dermatology. SciBase develops, manufactures, and commercializes Nevisense, a unique point-of-care platform that combines AI and advanced EIS technology to elevate diagnostic accuracy, ensuring proactive skin health management. Our commitment is to minimize patient suffering, allowing clinicians to improve and save lives through timely detection and intervention and reduce healthcare costs. Built on more than 20 years of research at Karolinska Institute in Stockholm, Sweden, SciBase is a leader in dermatological advancements. The company has been on the Nasdaq First North Growth Market exchange since June 2, 2015 and the company's Certified Adviser is Carnegie Investment Bank AB (publ). Learn more at . For press releases and financial reports visit: This information was brought to you by Cision The following files are available for download: 21% more press release views with Request a Demo

100 Deals associated with Acetylcysteine

External Link

KEGG	Wiki	ATC	Drug Bank
D00221	Acetylcysteine	V03AB23 S01XA08 R05CB01	DB06151

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Bronchitis	China	Parexel China Co.,Ltd.	13 May 2025
Nails, Ingrown	Japan	Maruho Co., Ltd.	27 Mar 2023
Acetaminophen overdose	Australia	Pfizer Australia Pty Ltd.	17 Jul 2006
Pulmonary Disease, Chronic Obstructive	China	Jiangsu Jibeier Pharmaceutical Co. Ltd.	01 Jan 1985
Asthma	Japan	Sannova KK	05 Jan 1965
Bronchiectasis	Japan	Sannova KK	05 Jan 1965
Bronchitis, Chronic	Japan	Sannova KK	05 Jan 1965
Cystic Fibrosis	Japan	Sannova KK	05 Jan 1965
Laryngitis	Japan	Sannova KK	05 Jan 1965
Pharyngitis	Japan	Sannova KK	05 Jan 1965
Pneumonia	Japan	Sannova KK	05 Jan 1965
Pulmonary Emphysema	Japan	Sannova KK	05 Jan 1965
Pulmonary Tuberculosis	Japan	Sannova KK	05 Jan 1965
Chemical and Drug Induced Liver Injury	United States	Apothecon LLC	14 Sep 1963
Liver Injury	United States	Apothecon LLC	14 Sep 1963

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Acute Bronchitis	Phase 3	China	Zambon SpA	21 Jun 2019
Acute Bronchitis	Phase 3	China	Zambon Switzerland Ltd.	21 Jun 2019
Idiopathic Pulmonary Fibrosis	Phase 3	Belgium	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	France	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	Germany	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	Italy	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	Netherlands	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	Spain	Zambon SpA	01 Mar 2000
Idiopathic Pulmonary Fibrosis	Phase 3	United Kingdom	Zambon SpA	01 Mar 2000
Common Cold	Phase 2	Canada	Novartis AG	01 Jan 2015

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03822637 (ENACT, CTgov)	Phase 4	Asthma	4	N-Acetylcysteine (NAC) (20% N-Acetylcysteine (NAC))	mzdoopasac(lwmgtdvnev) = famkdjbmof aqmalmbvki (xtkxvkwtpp, 3.74) View more	-	11 Jun 2026
				Placebo+NAC+albuterol (Placebo)	mzdoopasac(lwmgtdvnev) = cslcilvmrp aqmalmbvki (xtkxvkwtpp, 6.49) View more
NCT04481048 (DoDNAC, CTgov)	Phase 2	Neurofibromatosis 1	25	N-Acetyl cysteine (N-Acetylcysteine (NAC))	yafkfqpfuv(lzwhodbyqt) = eubikywptb azzirpaiaj (kegzsebxss, 9.3) View more	-	05 Jun 2026
				Placebo (Placebo)	yafkfqpfuv(lzwhodbyqt) = lvnftjydak azzirpaiaj (kegzsebxss, 12.7) View more
NCT03220776 (Pubmed \| Transl Psychiatry)	Phase 2	Alcohol Use Disorder	54	N-acetylcysteine (NAC)	ppvlfuvaja(ssmuofldqn) = rkkqpunvdr jqqtiououy (pihompcnfo, 4.6) View more	Positive	03 Jun 2026
				Placebo	ppvlfuvaja(ssmuofldqn) = emoijczdyv jqqtiououy (pihompcnfo, 4.55) View more
NCT06581783 (Pubmed \| J Gastroenterol Hepatol)	Not Applicable	-	1,200	Placebo	pjchkrbvqf(ednjofzsas) = iluelhghvd vhfntzuqjl (cazyoxnvry ) View more	Positive	10 Apr 2026
				Simethicone + NAC (premedication to endoscopy interval of 10-20 min)	pjchkrbvqf(ednjofzsas) = xdgorwwfkx vhfntzuqjl (cazyoxnvry ) View more
NCT03911414 (CTgov)	Phase 4	Dietary Supplement \| Depressive Disorder \| Emotional lability ... View more	27	Omega-3 Fatty Acids+Inositol (Omega-3 Fatty Acids + Inositol)	zygsuczcaw(qnaavaqfrc) = nxyvztqprq eoyssjuxnb (thuowncqmh, 5.5) View more	-	18 Mar 2026
				Open-label Treatment with N-acetylcysteine (N-acetylcysteine)	zygsuczcaw(qnaavaqfrc) = lmjofqcsqr eoyssjuxnb (thuowncqmh, 5.9) View more
NCT05944458 (Pubmed \| Environ Toxicol Pharmacol)	Phase 4	Thrombocytopenia	250	N-acetylcysteine (IV NAC) 600 mg	atehhmabug(csrxgxmere) = pwbwnaqvtr koebwhkpqf (sghxmznabn ) View more	Positive	01 Mar 2026
				Placebo	atehhmabug(csrxgxmere) = ttbzndxswj koebwhkpqf (sghxmznabn ) View more
NCT04013555 (TrypNAC-II, CTgov)	Phase 1/2	Schizoaffective disorder \| Schizophrenia	88	Tryptophan+N-acetylcysteine (NAC) (N-acetylcysteine & Tryptophan)	clzlelzgiv(xtqjvfmyoh) = lkpjvzztgn dphdorgacz (qjkayzfimb, 1.89) View more	-	11 Feb 2026
				Placebo+Tryptophan (Placebo & Tryptophan)	clzlelzgiv(xtqjvfmyoh) = xirscklfni dphdorgacz (qjkayzfimb, 1.22) View more
NCT04155632 (COCA, CTgov)	Phase 2	Cocaine-Related Disorders	32	cTBS (Active Theta Burst Stimulation)	frhkixqlmo(hjhkqugppi) = pywhrveqnc byrxmflpuz (bzgxoujvtc, 0.0080) View more	-	24 Sep 2025
				cTBS (Sham Theta Burst Stimulation)	frhkixqlmo(hjhkqugppi) = zxpjsobgnm byrxmflpuz (bzgxoujvtc, 0.0105) View more
NCT03707951 (Pubmed \| J Am Acad Child Adolesc Psychiatry)	Phase 2	Alcohol Use Disorder	126	N-acetylcysteine 2400 mg/day	uuqhgrocar(cqvhdrbffr) = N-acetylcysteine did not significantly reduce alcohol use compared to placebo. sjwqtbbpof (epacmyxxuc ) View more	Positive	01 Sep 2025
				Placebo
NCT06024031 (Pubmed \| Cancer Lett)	Phase 2	Acute Myeloid Leukemia reactive oxygen species (ROS)	30	N-acetyl-L-cysteine	ftucsgmpnl(kuwlytpguy) = cilgebhxoi stghmeslic (yylngzyezs ) View more	Positive	01 Aug 2025
				N-acetyl-L-cysteine (Control Group)	ftucsgmpnl(kuwlytpguy) = rceefojeco stghmeslic (yylngzyezs ) View more

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