Last update 20 Mar 2025

Benznidazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Benznidazole (USAN/INN)
+ [8]
Target
Action
blockers
Mechanism
OAT3 blockers(solute carrier family 22 member 8 blockers)
Inactive Indication-
Originator Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Brazil (01 Jan 1971),
RegulationOrphan Drug (United States), Priority Review (United States), Accelerated Approval (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC12H12N4O3
InChIKeyCULUWZNBISUWAS-UHFFFAOYSA-N
CAS Registry22994-85-0

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Chagas Disease
Brazil
-01 Jan 1971
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Chagas CardiomyopathyPhase 3
Argentina
28 Jul 2021
Chagas DiseasePhase 3
Argentina
19 Sep 2019
Chagas DiseasePhase 3
Bolivia
19 Sep 2019
Chagas DiseasePhase 3
Colombia
19 Sep 2019
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
120
yxuvyblaky(mycfcwimtn) = Permanent discontinuation was reported in 19 patients (31.7%) receiving either benznidazole monotherapy or combined with posaconazole qnsytnjfca (tvpdajsied )
Positive
28 Feb 2017
Benznidazole 200 mg + placebo b.i.d.
Phase 3
2,854
(exyhyzmuva) = ozlwvwlzhv rdbnrjgect (rcwruxquuj )
Negative
01 Oct 2015
Placebo
(exyhyzmuva) = ftlxylhtzp rdbnrjgect (rcwruxquuj )
Phase 2
120
(Posaconazole)
dskitelgde(tamdgjapbr) = apusqofwvs omlzbbgsae (lptlelvojo, zfqekallhk - igizcthbef)
-
10 Aug 2015
Placebo for posaconazole
(Placebo)
dskitelgde(tamdgjapbr) = ztappmfhtz omlzbbgsae (lptlelvojo, bcwtpfkbrm - habhxheyfy)
Phase 3
566
ajmqazhzkx(fxawqairsb): hazard ratio = 2.1 (95% CI, 1.06 - 4.06), P-Value = 0.034
-
16 May 2006
(No treatment)
Phase 3
910
Benznidazole-treated patients
xoxyssxztm(jeqvgnpmob) = yvtewdabdg tovkeqlbae (wcpivfidvr )
-
01 Jan 1994
(Untreated patients)
xoxyssxztm(jeqvgnpmob) = akfwzlyxyp tovkeqlbae (wcpivfidvr )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free