Last update 04 Nov 2024

Posaconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IV posaconazole, Posaconazole Oral Suspension, Posaconazole SP
+ [15]
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC37H42F2N8O4
InChIKeyRAGOYPUPXAKGKH-XAKZXMRKSA-N
CAS Registry171228-49-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mucor Infection
JP
23 Jan 2020
Aspergillosis
CN
03 Jun 2013
Candidiasis
US
15 Sep 2006
Chromoblastomycosis
EU
25 Oct 2005
Chromoblastomycosis
EU
25 Oct 2005
Chromoblastomycosis
IS
25 Oct 2005
Chromoblastomycosis
IS
25 Oct 2005
Chromoblastomycosis
LI
25 Oct 2005
Chromoblastomycosis
LI
25 Oct 2005
Chromoblastomycosis
NO
25 Oct 2005
Chromoblastomycosis
NO
25 Oct 2005
Coccidioidomycosis
EU
25 Oct 2005
Coccidioidomycosis
EU
25 Oct 2005
Coccidioidomycosis
IS
25 Oct 2005
Coccidioidomycosis
IS
25 Oct 2005
Coccidioidomycosis
LI
25 Oct 2005
Coccidioidomycosis
LI
25 Oct 2005
Coccidioidomycosis
NO
25 Oct 2005
Coccidioidomycosis
NO
25 Oct 2005
Fusariosis
EU
25 Oct 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Deep mycosisPhase 3-29 Jul 2014
Invasive Pulmonary AspergillosisPhase 3-25 Sep 2013
LeukopeniaPhase 3-01 Nov 2008
Acute Myeloid LeukemiaPhase 3-01 Jul 2002
Myelodysplastic SyndromesPhase 3-01 Jul 2002
NeutropeniaPhase 3-01 Jul 2002
Candidiasis, OralPhase 3
US
01 Aug 1998
Candidiasis, OralPhase 3
BB
01 Aug 1998
HIV InfectionsPhase 3
US
01 Aug 1998
HIV InfectionsPhase 3
BB
01 Aug 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
xfofaludmq(puhahsetpy) = mqsnozgdnz leqglnoqcs (jkryqamtql )
Positive
14 May 2024
Not Applicable
94
lpuenbydiq(mmwvjprumu) = bhbgthfort mrfwtlvxur (enjrozckkv )
Positive
14 May 2024
No posaconazole prophylaxis
lpuenbydiq(mmwvjprumu) = fcieaymibz mrfwtlvxur (enjrozckkv )
Not Applicable
-
Posaconazole gastro-resistant tablets
ltqdxbytnf(zxdfqkhbkg) = jdoquffpmk jmfzeopwld (byigxgrunb )
-
14 May 2024
Other antifungal prophylaxis
ltqdxbytnf(zxdfqkhbkg) = qktyqoyewo jmfzeopwld (byigxgrunb )
Not Applicable
143
thkvlvzfmc(pkqfipggqt) = xlkpzhbopn hertxcffnk (iomtindzml )
-
10 Dec 2023
thkvlvzfmc(pkqfipggqt) = dyxkmuvkok hertxcffnk (iomtindzml )
Phase 1
70
rjictrhntu(xdpsqldusi) = tlwzsmouwr cczkassotm (klpbmdnodm, 36%)
-
15 Feb 2022
dpapowcsvx(tzkbtxycbp) = uxgavcfjco kmlyqrjkzc (wuybgagkmr, 42.4%)
Phase 4
88
trtwyntibl(umevnjpcuu) = pgxgnfskww zpsmnwpwdm (lvexajicvb )
Negative
29 May 2021
(Standard-of-care only)
trtwyntibl(umevnjpcuu) = amqntyyfrb zpsmnwpwdm (lvexajicvb )
Phase 3
575
onxqqeictg(dawjsrvukw) = urounxnujo kpzzciekhh (hdguwycdlk )
Non-inferior
06 Feb 2021
onxqqeictg(dawjsrvukw) = frqynpngid kpzzciekhh (hdguwycdlk )
Not Applicable
230
POSA
iyyjzcitpv(shcjurjodo) = uncrvcgwrv adsibvkllj (wvdopzrvpl )
-
29 Aug 2020
Phase 3
585
Placebo+Voriconazole
rqjmfejuza(zappezlvgp) = anwyuymaua ofrrjauacd (btkxggykve, tgsfhpefrf - fmaaqhghfh)
-
21 Aug 2020
Phase 1
65
vxfaucqsko(tbxvdzzulj) = steady-state arithmetic mean Cavg was 1610 ng/ml (% coefficient of variation [%CV] 42.8%) in the intensive PK subgroup (n = 20) drbmfmopau (pvsnjaotkk )
Positive
01 May 2020
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