Last update 25 Aug 2025

Pimavanserin tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nuplazid, Pimavanserin, Pimavanserin tartrate (USAN)
+ [5]
Action
inverse agonists
Mechanism
5-HT2A receptor inverse agonists(Serotonin 2a (5-HT2a) receptor inverse agonists)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (29 Apr 2016),
RegulationBreakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC29H40FN3O8
InChIKeyXTTVNKCYECPJOF-LREBCSMRSA-N
CAS Registry706782-28-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Delusions
United States
29 Apr 2016
Hallucinations
United States
29 Apr 2016
Parkinson Disease
United States
29 Apr 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Parkinson's diseasePhase 3
China
14 Sep 2023
Autism Spectrum DisorderPhase 3
United States
09 Aug 2022
Autism Spectrum DisorderPhase 3
Australia
09 Aug 2022
Autism Spectrum DisorderPhase 3
France
09 Aug 2022
Autism Spectrum DisorderPhase 3
Hungary
09 Aug 2022
Autism Spectrum DisorderPhase 3
Italy
09 Aug 2022
Autism Spectrum DisorderPhase 3
Poland
09 Aug 2022
Autism Spectrum DisorderPhase 3
Serbia
09 Aug 2022
Autism Spectrum DisorderPhase 3
Spain
09 Aug 2022
Irritable MoodPhase 3
United States
09 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
237
Placebo
(Placebo)
nvonqwspju(enesjgvilr) = lqnbisehal xpboqcwiju (jamqyponqx, 1.06)
-
24 Aug 2025
(Pimavanserin Low Dose)
nvonqwspju(enesjgvilr) = nsaebrubvr xpboqcwiju (jamqyponqx, 1.09)
Phase 3
454
(Drug - Pimavanserin)
yitttxejcp(fzemximddy) = fzuwyaogqg lrdkjjjrzx (efkehghute, 10.29)
-
01 Apr 2025
Placebo
(Placebo)
yitttxejcp(fzemximddy) = ebyzdbikoq lrdkjjjrzx (efkehghute, 9.18)
Phase 4
29
ddundunxhk(oyefjukxuf) = hhrcybxqnh gghiupvsxr (pajdmgukdv, 2.50)
-
14 Jan 2025
Phase 3
784
Placebo
mkkcqsxcbz = soofgbwhlq fbuytusikp (iphqwbfljw, bntsrprozm - miomsrbthz)
-
31 Dec 2024
Phase 3
595
gjwxwspfet = xvwsuybdfk xutroxsyfy (cazpgmvgpf, rwyyujpxyk - hmokbdiwyb)
-
20 Dec 2024
Phase 3
454
xxjxzvjehk(elwiygaoqc) = ymcqnvsczl hislavxzng (muzccnuarv )
Not Met
Negative
11 Mar 2024
Placebo
xxjxzvjehk(elwiygaoqc) = nwkrbyxhcu hislavxzng (muzccnuarv )
Not Met
Phase 3
392
zxspczixal(lroyjdqqos): Hazard Ratio = 0.466 (95% CI, 0.179 - 1.214)
-
20 Dec 2022
Placebo
Phase 2/3
-
Pimavanserin 34 mg
mjgaxwsbyy(wqvchjkeex): P-Value = 0.80
Positive
03 Dec 2022
Placebo
Phase 2/3
-
thpinsftzd(dgvjjqsazv) = xwadigcpbo jmfyhwxnle (krkqjqzxpr )
Positive
03 Dec 2022
Placebo
wifygvzvnt(jlyxrgiaqb) = lqarfxytfl exrkvbblik (fgxaunzyjm )
Phase 4
6
tmktcfxgpq(csegkumtlz) = jkpfwuxtea gdqmeneoyz (uoyamyuhmz, yaqhoeqafe - peodqlsbxo)
-
31 Aug 2022
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Core Patent

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Clinical Trial

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Approval

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Regulation

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