Last update 01 Nov 2024

Akathisia, Drug-Induced

Last update 01 Nov 2024

Basic Info

Synonyms

Acathisia, Drug Induced, Acathisia, Drug-Induced, Akathisia caused by drug

+ [26]

Introduction

A condition associated with the use of certain medications and characterized by an internal sense of motor restlessness often described as an inability to resist the urge to move.

Drugs associated with Akathisia, Drug-Induced

Pimavanserin tartrate

Target

5-HT2A receptor

Mechanism

5-HT2A receptor inverse agonists

Active Org.

ACADIA Pharmaceuticals, Inc. [+1]

Originator Org.

ACADIA Pharmaceuticals, Inc.

Active Indication

Delusions [+11]

Inactive Indication

Agitation [+7]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date29 Apr 2016

Trihexyphenidyl Hydrochloride

Target

mAChRs

Mechanism

mAChRs antagonists

Active Org.

Towa Pharmaceutical Co., Ltd. [+3]

Originator Org.

Lederle Laboratories

Active Indication

Dyskinesias [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date13 May 1949

Haloperidol Lactate

Target

D2 receptor

Mechanism

D2 receptor antagonists

Active Org.-

Originator Org.

Johnson & Johnson

Active Indication-

Inactive Indication

Akathisia, Drug-Induced [+4]

Drug Highest PhaseWithdrawn

First Approval Ctry. / Loc.

First Approval Date12 Apr 1967

Clinical Trials associated with Akathisia, Drug-Induced

IRCT20191218045795N7 / SuspendedPhase 3IIT

The effectiveness of cyproheptadine in the treatment of acute akathisia caused by neuroleptics

Start Date21 Mar 2023

Sponsor / Collaborator-

IRCT20191218045795N5 / RecruitingPhase 3IIT

The effect of mirtazapine on neuroleptic-induced acute akathisia

Start Date07 Feb 2022

Sponsor / Collaborator-

IRCT20191218045795N1 / CompletedPhase 3IIT

The effect of trazodone on neuroleptic-induced acute akathisia

Start Date03 Feb 2019

Sponsor / Collaborator-

100 Clinical Results associated with Akathisia, Drug-Induced

100 Translational Medicine associated with Akathisia, Drug-Induced

0 Patents (Medical) associated with Akathisia, Drug-Induced

Literatures (Medical) associated with Akathisia, Drug-Induced

01 Dec 2024·Asian Journal of Psychiatry

Management of tardive dyskinesia and tardive dystonia with clozapine: A retrospective study

Article

Author: Chakrabarti, Subho ; Chaurasia, Nishtha ; Grover, Sandeep

AIMThis retrospective study aimed to evaluate the long-term effectiveness of switching to clozapine in the management of tardive syndromes (TS).METHODOLOGYThe treatment records of patients who had TS at the time of starting clozapine, were reviewed and demographic and clinical data was extracted on a predesigned performa.RESULTSAbout three-fourth (74.2 %) of the study subjects had tardive dystonias and two-third (69.7 %) had tardive dyskinesia at the time of starting clozapine. About half (48.5 %) of the patients had both tardive dystonia and dyskinesia. A small proportion (13.6 %) also had tardive akathisia at the time of starting clozapine. About three-fourth (72.2 %) of the patients had >50 % reduction, and about two-third (66.6 %) of the patients had >75 % reduction and nearly half (54.5 %) of the patients had complete resolution of dyskinesia at the last follow-up. Similar trends were seen in reduction in dystonia, i.e., >50 % reduction in 74.3 %, >75 % reduction in 62.2 % and complete resolution was seen in 56.1 %.CONCLUSIONSThe present study suggest that clozapine is useful in the management of drug induced tardive dyskinesia and tardive dystonia.

01 Nov 2024·Current Drug Safety

Antidepressant-induced Paradoxical Anxiety, Akathisia, and Complex Vocal Tics in a Patient with Panic Disorder and Crohn’s Disease: A Case Report

Article

Author: Lim, Leslie ; HK Koh, Azriel ; Loh, Soon Shan

Background:Antidepressant-induced paradoxical anxiety is a fairly common phenomenon seen in patients who are initiated on antidepressants. However, akathisia is a very uncommon manifestation of antidepressants. Much more rarely, antidepressants are also associated with the emergence of motor and vocal tics. This case adds to the growing literature of rare adverse events induced by antidepressants and aims to stimulate future research into the mechanism and risk factors of this phenomenon.Case Presentation:In this case report, we describe a patient with panic disorder and co-morbid Crohn’s disease who developed worsening anxiety, akathisia and vocal tics upon initiation of fluvoxamine. This is the first case report to describe the emergence of both akathisia and vocal tics in the same patient following antidepressant initiation. After discontinuation of fluvoxamine, the patient’s symptoms resolved.Conclusion:Antidepressant-induced akathisia and tics are often distressing both to the patient and their loved ones, and they can be very puzzling to the clinician. It is important for clinicians to recognise that, although rare, antidepressants can have the adverse effects of akathisia and tics in patients. When these symptoms arise, it should prompt immediate discontinuation of the offending antidepressant.

11 Mar 2024·SLEEP

Restless legs syndrome, neuroleptic-induced akathisia, and opioid-withdrawal restlessness: shared neuronal mechanisms?

Article

Author: Earley, Christopher J ; García-Borreguero, Diego ; Ferré, Sergi ; Chang, Joy H ; Winkelman, John W ; Belcher, Annabelle M

AbstractRestlessness is a core symptom underlying restless legs syndrome (RLS), neuroleptic-induced akathisia, and opioid withdrawal. These three conditions also share other clinical components suggesting some overlap in their pathophysiology. Recent prospective studies demonstrate the frequent incidence of RLS-like symptoms during opioid withdrawal and supervised prescription opioid tapering. Based on the therapeutic role of µ-opioid receptor (MOR) agonists in the three clinical conditions and recent preclinical experimental data in rodents, we provide a coherent and unifying neurobiological basis for the restlessness observed in these three clinical syndromes and propose a heuristic hypothesis of a key role of the specific striatal neurons that express MORs in akathisia/restlessness.

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Akathisia, Drug-Induced

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