Serelaxin

Montreal, Quebec – November 19, 2025 – Thryv Therapeutics Inc., a clinical-stage biotechnology company advancing a series of novel serum glucocorticoid inducible kinase 1 (SGK1) inhibitors for inherited cardiac arrhythmias, cardiometabolic diseases, and cardiomyopathies, today announced that new preclinical data will be presented at the American Heart Association’s Scientific Sessions 2025, taking place November 8–10 in New Orleans, Louisiana. The American Heart Association’s Scientific Sessions bring together global experts to exchange the latest advancements in cardiovascular science, clinical care, and research. Thryv Therapeutics is honored to contribute to this important dialogue with its recent research highlighting the potential of SGK1 inhibition as a novel therapeutic strategy for cardiovascular disease, including heart failure. Dr. Rudolph currently serves as Head of Global Medical Affairs and Cross-TA Medical Affairs at Boehringer Ingelheim, where she leads a global transformation to build a market-leading Medical Affairs organization focused on external engagement, digital/AI integration, evidence generation, advanced analytics, and learning. “We are thrilled to welcome Amy Rudolph to our Board of Directors,” said Paul Truex, Chairman and CEO of Thryv Therapeutics. “Her extensive experience in medical affairs, evidence generation, and cross-functional drug development will be invaluable as we progress our SGK1 inhibitor pipeline toward late-stage clinical studies.” “We are also deeply grateful to Scott Weiner for his many contributions to the Board of Directors,” added Truex. “We’re pleased that he will remain closely involved with Thryv in an advisory capacity.” Prior to joining Boehringer Ingelheim, Dr. Rudolph held leadership roles at Novartis Pharmaceutical Corporation, where she served as Head of HCS (Healthcare Systems) Partnerships in Global Drug Development and Head of Evidence and Launch Excellence in Global Medical Affairs. Earlier in her career, she held key positions at Pfizer Inc., where she was responsible for the atherosclerosis and stroke platforms, early development, and licensing/technology evaluations, and began her scientific career with G.D. Searle/Pharmacia/Pfizer. Over the course of her career, Dr. Rudolph has played key roles in the development and launch of multiple cardiovascular therapies, including Inspra, Eliquis, Lipitor, Diovan, Diovan/HCT, Exforge, Tekturna, and Entresto, as well as in the development of Serelaxin and Amturnide. Dr. Rudolph earned her Ph.D. in Biochemistry and Molecular Biology from Washington University in St. Louis and is an inventor on 13 patents and numerous scientific publications spanning preclinical research, drug development, and real-world evidence. “I am honored to join Thryv Therapeutics’ Board of Directors,” said Amy Rudolph. “Thryv’s science and patient-centered mission resonate deeply with me, and I look forward to supporting the company’s continued progress in addressing serious cardiovascular conditions.” Dr. Rudolph joins the Board of Directors as Scott Weiner, who has served as a valued member since 2021, transitions to an observer role. Mr. Weiner will remain on the Board of Directors of the company’s subsidiary, Thryv Therapeutics USA, Inc., while also serving as an advisor to the company. About Thryv’s SGK1 Inhibitor Platform Thryv Therapeutics is advancing a portfolio of potent and selective SGK1 (serum and glucocorticoid-regulated kinase 1) inhibitors that target the fundamental mechanisms driving electrical and structural remodeling in the heart. THRV-1268, the company’s lead clinical candidate, is a best-in-class, highly selective SGK1 inhibitor with the potential to transform the treatment landscape for Long QT Syndrome (LQTS), heart failure (HF), and atrial fibrillation (AFib)—three serious cardiac conditions with urgent unmet medical needs. About Thryv Therapeutics Inc. Thryv Therapeutics Inc. is a privately owned company based in Montreal, Quebec, Canada. Thryv is pioneering a precision medicine approach to treat genetic channelopathies, cardiometabolic diseases, and cardiomyopathies with potent and highly selective inhibitors of serum glucocorticoid inducible kinase 1 (SGK1). For more information, please visit www.thryvtrx.com. Media Inquiries brittany@thryvtrx.com | 514 973 0915

Eli Lilly is discontinuing a Phase 2 relaxin treatment candidate for heart failure and chronic kidney disease, a spokesperson for the company confirmed to Endpoints News . The drug, an under-the-skin injection known as volenrelaxin, was being tested in an approximately 450-patient trial in people with worsening chronic heart failure who have preserved ejection fraction, or HFpEF. It was also in a Phase 2 chronic kidney disease trial. That study was terminated “due to a lack of foreseeable clinical benefit,” according to an update to the US federal trials database this week. The trial began just three months ago and only enrolled eight patients, versus an original expectation of 280 patients, according to historical records of the trial. A trial of the drug in the EU was stopped in November, according to a European clinical trials database. “Details will be shared at a future medical meeting. No safety concerns were identified,” the Lilly spokesperson said Tuesday afternoon. Volenrelaxin is still listed on the Indianapolis pharma giant’s pipeline page. Many large pharmas will announce shifts to their clinical development plans during quarterly earnings. Lilly’s quarterly update is slated for Feb. 6. The biologic aims to activate the relaxin family peptide receptor 1. The first big program in the space was Novartis’ serelaxin, but it failed a Phase 3 in 2017 . Still in the game are AstraZeneca, with AZD5462 in Phase 2b in chronic heart failure, and Tectonic Therapeutic, which went public last year hoping to break into the space with its mid-stage candidate called TX45. Tectonic’s shares $TECX tanked 40% on Tuesday in an apparent reaction to the news. Its shares had regained about 10% in premarket trading on Wednesday. Leerink Partners analyst David Risinger noted in a Tuesday evening report that Lilly’s candidate “employed a human relaxin analog fused with a serum albumin-binding VHH domain to extend its half-life.” Tectonic’s TX45, meanwhile, uses an Fc-fusion approach that is similar to AstraZeneca’s candidate, Risinger added. The analyst also noted differences in trial endpoints and particular HFpEF patients being studied. Lilly’s work in heart failure also includes a Phase 3 of its obesity and diabetes medication tirzepatide. Last August, the trial showed tirzepatide helped reduce the risk of heart failure in patients with HFpEF. A Phase 1 is also investigating a long-acting “atrial natriuretic peptide” for heart failure. Retatrutide, its so-called “triple G” candidate for cardiometabolic health, is also being tested in patients with chronic kidney disease. Editor’s note: This story was updated to include stock reaction and information from an analyst note.