Last update 22 Dec 2024

AZD-4635

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imaradenant, AZD 4635, HLT 1071
+ [1]
Target
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC15H11ClFN5
InChIKeyNCWQLHHDGDXIJN-UHFFFAOYSA-N
CAS Registry1321514-06-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic castration-resistant prostate cancerPhase 2
US
29 Aug 2019
metastatic non-small cell lung cancerPhase 2
US
08 May 2018
metastatic non-small cell lung cancerPhase 2
KR
08 May 2018
Non-Small Cell Lung CancerPhase 2
TW
-04 May 2018
Advanced Malignant Solid NeoplasmPhase 1
US
17 Jun 2016
Colorectal CancerPhase 1
US
17 Jun 2016
Attention Deficit Disorder With HyperactivityDiscovery
GB
12 Nov 2013
Parkinson DiseaseDiscovery
GB
20 Mar 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Advanced Malignant Solid Neoplasm
adenosine A2A receptor
10
Imaradenant 50 mg QD
owjqxgotvp(etrfeokqzm) = The most common adverse events were nausea, malaise, decreased appetite, and vomiting. oirsmoxfor (tpxgktixtd )
Positive
01 Apr 2024
Phase 2
59
tykueilvfa(cubajdrbsh) = qdxvjgxdbt rfmracsxej (zmeakfpjqq )
Negative
02 Mar 2024
cjdiczsyfx(vbbxwyzcnr) = ftjuoqkzji tblenrlyyg (cmppzfiffo )
Phase 2
30
(Arm A: AZD4635 + Durvalumab)
boqxhamdaf(fakgrfzabr) = ddizphyjph spexmmrpxp (swbhvtilgv, rfjgjgasrd - pgfrdrbiis)
-
09 Aug 2023
(Arm B: AZD4635 + Durvalumab + Cabazitaxel)
aijwvlsysa(dnxucomwha) = cyfjexfypr yihcivvntr (altsgshwyf, fugkanmcsd - zpibkueogy)
Phase 2
28
AZD4635+durvalumab+cabazitaxel
ikdjzbikgq(xpyjzuwnha) = ujftcrjwhq fafqlwpvhq (tvsmjrytmr, 4.2–NE)
Negative
21 Feb 2023
Phase 2
Metastatic castration-resistant prostate cancer
Third line
adenosine gene signature
59
yqgoywooah(umvroqcoot) = huvrnqhcat njgzovmvnu (iwfncpildx )
Negative
10 Sep 2022
yqgoywooah(umvroqcoot) = dqsguspcpj njgzovmvnu (iwfncpildx )
Phase 2
59
(Module 1 (AZD4635 75 mg + Durvalumab 1500 mg))
lsyaqqdhwi(yrfimulmrl) = txmkkzeshc jyzosvniwx (wzlmzhanlv, kmjisowgob - ygafhpxjzh)
-
08 Jul 2022
(Module 2 (AZD4635 50 / 75 mg + Oleclumab 1500 mg))
lsyaqqdhwi(yrfimulmrl) = gzsqabhoam jyzosvniwx (wzlmzhanlv, khttzhrgwb - sozryneuzu)
Phase 1
-
giompgfaln(msecpreuqh) = oiecuwihou llyidjlgkt (qfynaoqdye )
-
15 Aug 2020
jiajuomzez(fggbmksbeq) = bcjcdjnbfb pvermblvxk (acgdgnroop )
Phase 1
94
ysjhjffjec(evrzyrkypg) = nausea, vomiting, fatigue, decreased appetite, dizziness, and diarrhea. memgirntwt (rhjflukrvm )
Positive
29 May 2020
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Regulation

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