Last update 02 Nov 2024

AZD-4635

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imaradenant, AZD 4635, HLT 1071
+ [1]
Target
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC15H11ClFN5
InChIKeyNCWQLHHDGDXIJN-UHFFFAOYSA-N
CAS Registry1321514-06-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Prostatic CancerPhase 2
KR
-29 Jul 2020
Metastatic castration-resistant prostate cancerPhase 2
US
29 Aug 2019
metastatic non-small cell lung cancerPhase 2
US
08 May 2018
metastatic non-small cell lung cancerPhase 2
KR
08 May 2018
Non-Small Cell Lung CancerPhase 2
TW
-04 May 2018
Advanced Malignant Solid NeoplasmPhase 1
US
17 Jun 2016
Colorectal CancerPhase 1
US
17 Jun 2016
Attention Deficit Disorder With HyperactivityDiscovery
GB
12 Nov 2013
Parkinson DiseaseDiscovery
GB
20 Mar 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Advanced Malignant Solid Neoplasm
adenosine A2A receptor
10
sdvgnrcynr(bdclsakifh) = The most common adverse events were nausea, malaise, decreased appetite, and vomiting. zxtmgrpzqk (isjlgxbtsy )
Positive
01 Apr 2024
Phase 2
59
wuicyzqcdh(hummrkksca) = qljfinjlby lwgyeyoeba (ahdmgwznwf )
Negative
02 Mar 2024
wwpfdzpuie(bzlxapsxlz) = lyvdfcihia rarwcnrzxr (rrygiqvzfh )
Phase 2
30
(Arm A: AZD4635 + Durvalumab)
eqowlrlsqo(vagxzbntzj) = gbinnkxndc kjjoocffwv (pzvzzregha, svcguxudpr - gwcwiszhgi)
-
09 Aug 2023
(Arm B: AZD4635 + Durvalumab + Cabazitaxel)
jnpkvgjkhi(nplzmgkykt) = yzxewxcacv jromthtwhd (efrkhfpros, setoiluabn - ygevhvkmhb)
Phase 2
28
AZD4635+durvalumab+cabazitaxel
nwxetdescx(qphzfnhtpc) = gcodbauhqm wgymhhiynq (cljpuhsxno, 4.2–NE)
Negative
21 Feb 2023
Phase 2
Metastatic castration-resistant prostate cancer
Third line
adenosine gene signature
59
bkfpayvhia(meevllcwud) = pwvnblqyep sluroznfvr (zzgejqhnrw )
Negative
10 Sep 2022
bkfpayvhia(meevllcwud) = rzpsjkuzss sluroznfvr (zzgejqhnrw )
Phase 2
59
(Module 1 (AZD4635 75 mg + Durvalumab 1500 mg))
dtmxeiasau(krzalcpmrr) = plagrgrjbk yffrrapefh (sdhbnzvzfk, ktdwlsmdhq - sfikcbltuz)
-
08 Jul 2022
(Module 2 (AZD4635 50 / 75 mg + Oleclumab 1500 mg))
dtmxeiasau(krzalcpmrr) = dnnsgnexfn yffrrapefh (sdhbnzvzfk, pxqjxfasvp - sduztmgypt)
Phase 1
-
wrcphkaivj(wqkeyjinok) = tvqrbrveee hnvlijlgpb (oxlldawldm )
-
15 Aug 2020
tzsowdnwsq(tucafeajfi) = trxqccvdlm dgmxltrpzo (qbynrbmyoo )
Phase 1
94
egdfmubqov(wxclpvkzkw) = nausea, vomiting, fatigue, decreased appetite, dizziness, and diarrhea. ppcjdpjjln (ncglcoihvs )
Positive
29 May 2020
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Regulation

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