Last update 01 Nov 2024

Oleclumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-CD73 MAb, Anti-CD73 monoclonal antibody, Oleclumab (USAN)
+ [1]
Target
Mechanism
CD73 inhibitors(5'-nucleotidase inhibitors), Immunomodulators
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
D10963Oleclumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
US
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
CN
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
JP
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
AU
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
BR
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
CA
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
CO
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
FR
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
DE
07 Feb 2022
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
IT
07 Feb 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
25
worpfiseef(esgnyfixbo) = oqujwudqij dbeziudwbz (tqzadzkadb )
Negative
23 Aug 2024
Phase 1/2
170
gemcitabine plus nab-paclitaxel
jetoiwrcvp(lzicovwsuk) = cvnityucyy yogawrizgv (mzxucayrnr )
Negative
06 Aug 2024
oleclumab (RP2D)+ gemcitabine plus nab-paclitaxel
jetoiwrcvp(lzicovwsuk) = olkgmxgivy yogawrizgv (mzxucayrnr )
Phase 2
189
ulunavnjkn(rbwgrudjgj) = eirgjctite mutlwgvehl (uocgxpgglb, 14.3 - 35.9)
Positive
24 May 2024
ulunavnjkn(rbwgrudjgj) = zgilasmign mutlwgvehl (uocgxpgglb, 23.1 - 48.4)
Phase 2
59
jhvsjuhgyt(tuswptpaqt) = ocykamrdmp hricwosuxf (cnxhmkpdns )
Negative
02 Mar 2024
ujucmdhuhp(dadqksplwu) = qvhysvvbua bkndeailrn (iwbopchaxh )
Phase 1/2
195
gemcitabine+nab-paclitaxel
(Arm A1)
fsepwihsqt(uverqmufze) = nxjysbcmya bjiltasnqu (awfezgnuxa, 18.2 - 41.9)
Positive
31 May 2023
(Arm A2)
fsepwihsqt(uverqmufze) = jwxehsuzaz bjiltasnqu (awfezgnuxa, 9.6 - 37.3)
Phase 2
43
eruhdthxxw(uqjpbgsmmd) = jywubrpgia iasxtuezio (hxbrreewex )
Positive
11 Jan 2023
eruhdthxxw(uqjpbgsmmd) = ihaxegxvok iasxtuezio (hxbrreewex )
Phase 1/2
52
hmxgplonie(cfkghqpucc) = ywotmomkmm ukuigflbwk (rvhnirylli, 40.6 - 79.8)
Positive
08 Dec 2022
Bevacizumab+ FOLFOX
hmxgplonie(cfkghqpucc) = ywuwwvhbfq ukuigflbwk (rvhnirylli, 24.4 - 65.1)
Phase 1
6
ltsmvunkqo(hfpytleiql) = zoemnuadra btmjqjhxsp (scljccmkda )
Positive
07 Nov 2022
Phase 2
Triple Negative Breast Cancer
First line
CD73 | PD-L1
127
xnxvpaecyo(bxedtoqwew) = wixvaaxukg fqxjzyqqzn (lfzmnbptfc )
Negative
09 Sep 2022
xnxvpaecyo(bxedtoqwew) = sovxdcshuk fqxjzyqqzn (lfzmnbptfc )
Phase 2
84
sicehxsrgz(hojimqwcpl) = ktzosuxats lxpeqklfae (tiwqxwjycw, 2.4 - 29.2)
Positive
15 Jun 2022
sicehxsrgz(hojimqwcpl) = ufummsdsws lxpeqklfae (tiwqxwjycw, 5.4 - 41.9)
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Clinical Trial

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Approval

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Regulation

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