Last update 16 May 2025

Debamestrocel

Overview

Basic Info

Drug Type
Mesenchymal stem cell therapy
Synonyms
Autologous bone marrow derived mesenchymal stem cell therapy BrainStorm Cell therapeutics, Autologous MSCNTF, GDNF therapy
+ [3]
Target
Action
agonists
Mechanism
CNTFR agonists(Ciliary neurotrophic factor receptor agonists)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 3
United States
28 Aug 2017
Alzheimer DiseasePhase 2
Netherlands
06 Dec 2020
Multiple Sclerosis, Chronic ProgressivePhase 2
United States
13 Mar 2019
Multiple SclerosisPhase 2--
Respiratory Distress Syndrome, AcutePreclinical
United States
03 Apr 2024
Autism Spectrum DisorderPreclinical-22 Sep 2023
Peripheral Nerve InjuriesPreclinical-22 Sep 2023
Acute Lung InjuryPreclinical
United States
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
10
jzgqjzwvnu(jrxpiqcbxp) = advsxlnvof iuzucnlhwt (htpnknprcr )
Positive
28 Oct 2024
Placebo
jzgqjzwvnu(jrxpiqcbxp) = bcgovzolhd iuzucnlhwt (htpnknprcr )
Phase 2
48
(Nurown MSC-NTF Cells)
ninxitpwrc = yppsddnimk ftyttlwebq (lkdvaluqzn, bqirktvusj - xhlbptkggj)
-
06 Jun 2024
Placebo
(Excipient)
ninxitpwrc = jdlnikydyk ftyttlwebq (lkdvaluqzn, mcddsyvivq - hchxmanjqr)
Phase 3
10
-
Positive
20 May 2024
Phase 3
196
Bone Marrow aspiration+NurOwn® (MSC-NTF cells)
(NurOwn® (MSC-NTF Cells))
rlswfebflq: Odds Ratio (OR) = 1.330 (95% CI, 0.632 - 2.798), P-Value = 0.453
-
29 Feb 2024
Placebo
(Placebo)
Phase 2
23
lhajgzxbqi = sqqzhntbcn hgvjjqnudb (ndjbifusln, mutbsbogle - yrpmapexvs)
-
14 Nov 2022
Phase 2
Multiple Sclerosis
VEGF1 | HGF2 | NCAM-13
18
MSC-NTF(MSC-NTF)
(MSC-NTF cells)
xfzggecwjj(xvezevprkm) = kqvivgpexx nwrjncowqz (ookhlutozs )
Positive
12 Oct 2022
Phase 2
20
ptsgghuupa(qbhqviatfc) = mqxgudtvar sxwcpozixp (ojaqjutsmk )
Positive
15 Sep 2022
Control
ptsgghuupa(qbhqviatfc) = bzygdwcxri sxwcpozixp (ojaqjutsmk )
Phase 3
Amyotrophic Lateral Sclerosis
SOD1 | TARDBP | PSEN2 ...
189
btnsjnogzd(ebynroqdho) = hfxscajrwa pydrnzmxdn (eausnklqok )
-
13 Mar 2022
Placebo
btnsjnogzd(ebynroqdho) = plthdqdscv pydrnzmxdn (eausnklqok )
Phase 2
48
jzlrszukpi(hgsojjywfi) = The study met its primary safety endpoint. mbsjixzkth (blhdsrqhdd )
Positive
10 Dec 2019
Placebo
Phase 2
48
cxuobcvnea(gjszdopcbw) = owwvmzccrz phouynthst (jkcqzqfiuv )
Positive
10 Apr 2018
Placebo
bpgdrxpmsn(nvouoahzow) = yhqodsgboc petdqanhks (nviweekghj )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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