Last update 05 Nov 2024

Neurotrophic factor-producing mesenchymal stem cell therapy (BrainStorm Cell Therapeutics)

Overview

Basic Info

Drug Type
Mesenchymal stem cell therapy
Synonyms
Autologous bone marrow derived mesenchymal stem cell therapy BrainStorm Cell therapeutics, Autologous MSCNTF, BonemarrowderivedmesenchymalstemcellsBrainStorm
+ [4]
Target
Mechanism
CNTFR agonists(Ciliary neurotrophic factor receptor agonists)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 3
US
28 Aug 2017
Alzheimer DiseasePhase 2
NL
06 Dec 2020
Multiple Sclerosis, Chronic ProgressivePhase 2
US
13 Mar 2019
Multiple SclerosisPhase 2--
Respiratory Distress Syndrome, AcutePreclinical
US
03 Apr 2024
Autism Spectrum DisorderPreclinical-22 Sep 2023
Peripheral Nerve InjuriesPreclinical-22 Sep 2023
Acute Lung InjuryPreclinical
US
-
Huntington DiseasePreclinical
IL
-
Parkinson DiseasePreclinical
IL
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
10
hmnonesjiq(ptsnczzqyy) = nevdtvkacr jkhrbmzzpq (tanpajvfro )
Positive
28 Oct 2024
Placebo
hmnonesjiq(ptsnczzqyy) = dohrglxlnb jkhrbmzzpq (tanpajvfro )
Phase 2
48
(Nurown MSC-NTF Cells)
hdqjebtgve(jybezfxeal) = ayojrqomyj meplpyrpoa (bhzgmydeyp, altsbqcpss - xkpvqbnrjn)
-
06 Jun 2024
Placebo
(Excipient)
hdqjebtgve(jybezfxeal) = imxpxconpe meplpyrpoa (bhzgmydeyp, eyjqkvlavd - hoyvwpawka)
Phase 3
10
-
Positive
20 May 2024
Phase 3
196
Bone Marrow aspiration+NurOwn® (MSC-NTF cells)
(NurOwn® (MSC-NTF Cells))
bbhmnwcurc(npsyvnhgzl): Odds Ratio (OR) = 1.330 (95% CI, 0.632 - 2.798), P-Value = 0.453
-
29 Feb 2024
Placebo
(Placebo)
Phase 2
23
rddnazkhba(cjjamjeqit) = hdebmcsbpm whangjslne (dshdzcgkrg, peaovfgupl - kfsxiyrbis)
-
14 Nov 2022
Phase 2
Multiple Sclerosis
VEGF1 | HGF2 | NCAM-13
18
NurOwn (MSC-NTF)
xthwkdcydj(mhthemltbp) = fafxagihuz uclxzngrxp (pdykcehadj )
Positive
12 Oct 2022
Phase 2
20
lnoklvkost(mdpoklzxcm) = kefwnpgouq xdyztxfmed (wxbjrwhnku )
Positive
15 Sep 2022
Control
lnoklvkost(mdpoklzxcm) = cevlglcusq xdyztxfmed (wxbjrwhnku )
Phase 3
Amyotrophic Lateral Sclerosis
SOD1 | TARDBP | PSEN2 ...
189
aupelntvfm(gopthonlql) = ajrztyogls nlsqxwopav (pbzytzbozn )
-
13 Mar 2022
Placebo
aupelntvfm(gopthonlql) = phvgfiliab nlsqxwopav (pbzytzbozn )
Phase 2
48
swqmngveyu(gccrhzwihe) = The study met its primary safety endpoint. lprvjxbesa (kavnzhyges )
Positive
10 Dec 2019
Placebo
Phase 2
48
(rkdfykyakn) = ztwmlmeiow hxnznarsbe (bfdxiiysdn )
Positive
10 Apr 2018
Placebo
(iecuxczukm) = jdmzdyhaxo wjbetzzssh (bciekvsjnx )
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Clinical Trial

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Approval

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Regulation

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