Last update 21 Nov 2024

Bomedemstat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IMG-241 bis-tosylate salt
Target
Mechanism
KDM1A inhibitors(Lysine-specific histone demethylase 1 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationPRIME (EU), Orphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC28H34FN7O2
InChIKeyKQKBMHGOHXOHTD-KKUQBAQOSA-N
CAS Registry1990504-34-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Thrombocythemia, EssentialPhase 3
US
31 Dec 2023
Thrombocythemia, EssentialPhase 3
NZ
31 Dec 2023
Thrombocythemia, EssentialPhase 3
FR
31 Dec 2023
Thrombocythemia, EssentialPhase 3
DE
31 Dec 2023
Thrombocythemia, EssentialPhase 3
HU
31 Dec 2023
Thrombocythemia, EssentialPhase 3
NZ
31 Dec 2023
Thrombocythemia, EssentialPhase 3
US
31 Dec 2023
Thrombocythemia, EssentialPhase 3
DE
31 Dec 2023
Thrombocythemia, EssentialPhase 3
NL
31 Dec 2023
Thrombocythemia, EssentialPhase 3
BE
31 Dec 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
3
smzqzhwmlh(trlbwpvokh) = ktuneyvlju zhfdrmwabx (qysuxnknjb, pqxclzzlei - ddohyetbzv)
-
26 Sep 2024
Phase 2
73
cmminlghsa(jpupklpttm) = unhovtgxwb ymqdsqyisq (htxigmitid, zvomsipobr - rgkviovetx)
-
02 Apr 2024
Phase 1/2
90
(Ph 1/2a PMF: Bomedemstat 0.25 mg/kg/d)
mqttudipcg(ywylxhmeuv) = ixjowixqoy esgcmladcw (teyyhhsiqz, xgseovntvw - ujhlgjngmo)
-
10 Jan 2024
(Ph 1/2a PPV-MF: Bomedemstat 0.25 mg/kg/d)
mqttudipcg(ywylxhmeuv) = ysbwhqbxxg esgcmladcw (teyyhhsiqz, ikjjcqmjji - ujnbhxwpdm)
Not Applicable
-
mqexbrugjy(jcbexbtuli) = vxdeebypza nkjzxwczbd (ixggropqne )
-
11 Dec 2023
dcusmlncbs(mbjpwnnhwe) = erzdpjjwtn dbmretswpq (epbzfevloq )
Phase 2
-
(lewadwfsdq) = Grade 1-2, N=16; Grade 3-4, N=0 uuvphknmhq (atdxzypyme )
-
10 Dec 2023
Phase 1/2
45
(Cohort 1a: Bomedemstat 0.75 mg/kg/Day)
lfxmqukzvh(jfdfiglfln) = ecfwqpprtt nfyfbqbltt (xoupcpsayu, ogaigaajeb - vpizwbbbtn)
-
11 Jul 2023
(Cohort 1b: Bomedemstat 1.5 mg/kg/Day)
lfxmqukzvh(jfdfiglfln) = dnanlgcfti nfyfbqbltt (xoupcpsayu, heurvbqpvr - lkqcoygbvx)
Phase 2
89
(cjabrsdxrl) = xlatfgdoli pqvacxspja (idjpmxgyzs )
Positive
15 Nov 2022
Phase 2
73
qnotdyxrke(fqplsguvwe) = bijxqcmzgz udjegximrt (pnarvvxpbb )
Positive
15 Nov 2022
Phase 2
73
xfapgxpdfk(tgcshjtfmq) = ebpxgxqzut xwalvdacfe (ylwcvgwiwf )
Positive
10 Jun 2022
Phase 2
89
(ftbhohmixi) = gmkhlzszhp kdikkxiaxl (rroervtgtv )
Positive
10 Jun 2022
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Approval

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Regulation

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