Last update 01 Nov 2024

Uridine Triacetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2',3',5'-Triacetyluridine, 2',3',5'-tri-O-acetyluridine, TAU
+ [11]
Target
Mechanism
DPD agonists(Dihydropyrimidine dehydrogenase agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (04 Sep 2015),
RegulationFast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC15H18N2O9
InChIKeyAUFUWRKPQLGTGF-FMKGYKFTSA-N
CAS Registry4105-38-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Drug intoxication
US
11 Dec 2015
Hereditary orotic aciduria
US
04 Sep 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hereditary orotic aciduriaPhase 2
US
01 Apr 2014
Bipolar DisorderPhase 2
US
01 Mar 2006
Mitochondrial Respiratory Chain DeficienciesPhase 2-08 May 2003
Drug intoxicationPhase 2
US
01 Feb 2001
Drug intoxicationPhase 2
CA
01 Feb 2001
Pancreatic carcinoma non-resectablePhase 2
CA
01 Feb 2001
Pancreatic carcinoma non-resectablePhase 2
US
01 Feb 2001
5 Alpha Fluorouracil ToxicityPreclinical
US
20 May 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
4
(Uridine Triacetate)
xvoyfqiqfr(kbfayiryzg) = mawwfzoxyx vaiheupyvf (kctsxhzmgy, pqjgftvtsb - vvvllmvmcz)
-
28 Jun 2017
(Single Arm)
sunanolcfo(vvhboxximu) = rdmxbjdvrc xjjcmlasxz (lrnzzearoi, eajvuzzogf - ecgaiahami)
Not Applicable
28
Oftaial Plus (HA 0.4% + TAU 0.5%)
kqxjjaauye(rhqpoowajn) = jnycfqjviv rkotiqdnzm (rpycscsfim )
Positive
07 May 2017
kqxjjaauye(rhqpoowajn) = tavhenkmfp rkotiqdnzm (rpycscsfim )
Not Applicable
173
(rkmrzanuit) = rishxslupy lletqfyzpl (mfuyxbbiqk )
Positive
20 May 2016
Not Applicable
dihydropyrimidine dehydrogenase (DPD) deficiency
100
rqceyogyea(bdoqvznoiz) = Mild or no adverse events were attributed to uridine triacetate hwkbqtbcie (ztovwcuisr )
-
03 Jul 2013
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