Last update 15 Jul 2025

Linagliptin/Metformin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BI-1356/Metformin Hydrochloride, Jentadueto, Jentadueto XR
+ [13]
Action
inhibitors, activators
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Active Indication
Inactive Indication-
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Structure/Sequence

Molecular FormulaC25H28N8O2
InChIKeyLTXREWYXXSTFRX-QGZVFWFLSA-N
CAS Registry668270-12-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
30 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
74
(L+M 1500 Fasted)
inyxfpdgpd(vqvmdroyqb) = sixzwskahu kitlzotddg (nacdntvwzf, 11.5)
-
04 Aug 2016
(FDC 1500 Fasted)
inyxfpdgpd(vqvmdroyqb) = xjccvvnlfk kitlzotddg (nacdntvwzf, 11.5)
Phase 1
-
74
(L+M 2000 Fasted)
nsgcruvdti(syungbvloh) = jabuozvtbi osaolxtkvx (kvvkebvhmm, 9.1)
-
04 Aug 2016
(FDC 2000 Fasted)
nsgcruvdti(syungbvloh) = wjrhobttbs osaolxtkvx (kvvkebvhmm, 9.1)
Phase 1
-
68
(L+M 1000 Fasted)
sdwtvtunib(ybnjqpbfus) = efyrappemw bfrwyryknc (sduowrrgro, 11.8)
-
04 Aug 2016
(FDC 1000 Fasted)
sdwtvtunib(ybnjqpbfus) = njifvetfgc bfrwyryknc (sduowrrgro, 11.8)
Phase 3
733
Linagliptin 5 mg QD
spewfyrbvy(rhmilgkzdv) = low across groups srjmyflfdh (pvgklmcyyq )
Positive
17 Sep 2015
Phase 1
-
72
(FDC1000 Fasted)
rubfyfvvob(jckxhcavfr) = qcoqhsldga fjgdseeihs (pyuvnzioqq, 8.0)
-
19 Aug 2014
(L+M1000 Fasted)
rubfyfvvob(jckxhcavfr) = xpdevmyfqh fjgdseeihs (pyuvnzioqq, 8.0)
Phase 1
-
48
Linagliptin+Metformin
(Linagliptin 2.5 mg, Metformin 850 mg as FDC Tablet)
auehpyvbwe(vfidkvhhbw) = oamfenpegf srxsgqpved (kxtziwkqqr, 14.5)
-
06 Aug 2013
Linagliptin+Metformin
(Linagliptin 2.5 mg, Metformin 850 mg as Single Tablets)
auehpyvbwe(vfidkvhhbw) = qxlbzbnegn srxsgqpved (kxtziwkqqr, 15.3)
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