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Overview

Tags

Nervous System Diseases

Endocrinology and Metabolic Disease

Other Diseases

Small molecule drug

Biological products

Therapeutic radiopharmaceuticals

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	5
Endocrinology and Metabolic Disease	4
Neoplasms	3
Infectious Diseases	2
Immune System Diseases	2
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	17
Therapeutic radiopharmaceuticals	1
Biological products	1

Top 5 Target	Count

DPP-4 x PRKAB1	1
HSF1(heat shock transcription factor 1)	1
COX(Cyclooxygenases)	1
nAChRα1/β1/δ/γ(Acetylcholine receptor; alpha1/beta1/delta/gamma)	1
Cytokines x TIGIT	1

Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five compounds, mulberroside C ( 1), moracin P ( 2), moracin O ( 3), moracin M ( 4) and mulberrofuran K ( 5) from the ethyl acetate-soluble fraction. Compounds 1 approximately 4 showed significant inhibitory activities. Compounds 2 and 3 showed potent inhibitory activity (IC (50) 35.6 microM, 80.8 microM, respectively) in the replicon cell assay, which was confirmed by NS3 helicase inhibitory activity (IC (50) 42.9 microM, 27.0 microM, respectively).

01 Mar 2007·Journal of Medicinal FoodQ4 · MEDICINE

Effects ofPicrorrhizaRhizoma Water Extracts on the Subacute Liver Damages Induced by Carbon Tetrachloride

Q4 · MEDICINE

Article

Author: Ku, Sae-Kwang ; Keum, Kyoung-Yeon ; Lee, Hyeung-Sik

The hepatoprotective activity of Picrorrhiza rhizoma (PR) water extract was evaluated on carbon tetrachloride (CCl(4))-induced subacute hepatic damage, induced by subcutaneous injection of CCl(4) (0.15 mL/kg of body weight) in pure olive oil (7.92%, vol/vol) three times a week for 10 weeks. Animals were sacrificed 10 weeks after oral administration of PR extracts at 50, 100, or 200 mg/kg or silymarin at 100 mg/kg, which were administered simultaneously with CCl(4); changes in body weight, liver weight, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were observed along with differences in liver histopathology and histomorphometry. In addition, liver malondialdehyde as an index for lipid peroxidation, hydoxyproline as an index for collagen synthesis, and protein content were determined. Ten weeks of CCl(4) injections caused subacute hepatic damage, featuring significantly less body weight gain and hepatic protein contents and higher liver weight, serum AST and ALT levels, and hepatic malondialdehyde and hydroxyproline contents with subacute hepatic damage-related histopathology of the liver. However, the CCl(4)-induced toxic effects were dramatically and dose-dependently inhibited by PR extract treatment. Thus oral administration of PR extracts significantly reduced CCl(4)-induced subacute hepatic damage in rats, probably by exerting a protective effect against hepatocellular necrosis via its free radical scavenging ability.

01 Jan 2005·World Journal of GastroenterologyQ3 · MEDICINE

Changes of the intestinal endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma (3LL): An immunohistochemical quantitative study

Q3 · MEDICINE

Article

Author: Kim, Jong-Dae ; Lee, Hyeung-Sik ; Kim, Dae-Young ; Seo, Bu-Il ; Lee, Jae-Hyun ; Choi, Hae-Yun ; Ku, Sae-Kwang ; Seong, Seung-Kyoo

AIMTo study the distributions and frequencies of intestinal endocrine cells in the C57BL/6 mouse with immunohistochemical method using seven types of specific antisera against chromogranin A (CGA), serotonin, somatostatin, glucagons, gastrin, cholecystokinin (CCK)-8 and human pancreatic polypeptide (hPP) after abdominal subcutaneous implantation of murine lung carcinoma (3LL).METHODSThe experimental animals were divided into two groups, one is non-implanted Sham and the other is 3LL-implanted group. Samples were collected from six regions of intestinal tract at 28(th) d after implantation of 3LL cells (1X10(5) cell/mouse).RESULTSIn this study, five types of immunoreactive (IR) cells were identified except for gastrin and hPP. The regional distributions of the intestinal endocrine cells in the 3LL-implanted group were similar to those of the non-implanted Sham. However, significant decreases of IR cells were detected in 3LL-implanted group compared to those of non-implanted Sham. CGA- and serotonin-IR cells significantly decreased in 3LL-implanted groups compared to that of non-implanted Sham. Somatostatin-IR cells in the jejunum and ileum and CCK-8-IR cells in the jejunum of 3LL-implanted groups significantly decreased compared to that of non-implanted Sham. In addition, glucagon-IR cells were restricted to the ileum and colon of non-implanted Sham.CONCLUSIONImplantation of tumor cell mass (3LL) induced severe quantifiable changes of intestinal endocrine cell density and the abnormality in density of intestinal endocrine cells may contribute to the development of gastrointestinal symptoms such as anorexia and indigestion, frequently encountered in patients with cancer.

100 Deals associated with DONG WHA PHARM Co., Ltd.

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100 Translational Medicine associated with DONG WHA PHARM Co., Ltd.

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Pipeline

Pipeline Snapshot as of 28 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

2

4

Preclinical

Phase 1 Clinical

6

1

Phase 2 Clinical

Approved

5

16

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Dapagliflozin/Sitagliptin ( DPP-4 x SGLT2 )	Diabetes Mellitus, Type 2 More	Approved
DW-166HC	Hemophilia A More	Approved
Choline Alfoscerate ( nAChRα1/β1/δ/γ )	Cognition Disorders More	Approved
Zabofloxacin D-aspartate ( Bacterial DNA gyrase x Topoisomerase IV )	Respiratory Tract Infections More	Approved
Loxoprofen Sodium Hydrate ( COX )	Pain More	Approved