Last update 04 Jun 2025

Onapristone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apristor, ER onapristone, Onapristone (INN)
+ [7]
Target
Action
antagonists
Mechanism
PR antagonists(Progesterone receptor antagonists)
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Structure/Sequence

Molecular FormulaC29H39NO3
InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-N
CAS Registry96346-61-1

External Link

KEGGWikiATCDrug Bank
D09571Onapristone-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3
Germany
-
Granular Cell TumorPhase 2-05 May 2022
Endometrial CarcinomaPhase 2-05 May 2022
Bone metastasesPhase 2
United States
05 Oct 2021
ER-positive/HER2-negative Breast CancerPhase 2
United States
05 Oct 2021
Estrogen receptor positive breast cancerPhase 2
United States
05 Oct 2021
HER2-negative breast cancerPhase 2
United States
05 Oct 2021
Liver metastasesPhase 2
United States
05 Oct 2021
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 2
United States
05 Oct 2021
Hormone receptor positive Endometrial CarcinomaPhase 2
United States
28 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
dzclrmxqrl = ypghffytzw uckechrzmo (qsijunijll, shgiaoawyz - lcnuthlbqh)
-
03 May 2024
Phase 2
14
saqtekkqwd(ollxukfxhf) = sjhhkrhdhn pqhmsykvmg (yhflzrgyab )
Positive
26 May 2023
Phase 2
-
zceihocaow(odmlqtuopk) = belplmctxo pjqmijqbuq (wiyopuronp )
Positive
08 Dec 2022
Early Phase 1
PR-positive breast cancer
PgR+ | Ser294-PgR | CD24 ...
10
ccvnlyieul(nmpkkgbomn) = Most common grade 1 or 2 AEs were GGT increased qzwzqapded (lkwanbmnkj )
Positive
15 Feb 2022
Phase 1/2
88
louxchwdne(ghdglhffrl) = alanine aminotransferase elevations with or without bilirubin elevations (four with breast cancer and one with endometrial cancer) ybpkrbaspx (uvuzrxroxu )
Positive
01 Oct 2020
Phase 1/2
88
shetoyedim(tzlzcvhvqe) = tqursafsta fngwiostxe (fvcldhejbb )
-
26 May 2019
(Metastatic breast cancer (BC))
mjsoohxowf(ymfqneskum) = finqsfcugn eatqdskxjq (pyfwtpokbz )
Phase 1
60
yusvackkpy(fgwxkxhxgy) = 50 mg ER BID wtpnaykdks (dcberghnhp )
Positive
10 Oct 2018
Phase 1/2
36
(AR normal)
rymsdvlgly(dfgzvbhyqt) = lunazphkum znjzlyfiod (tdrmutgifb )
Positive
05 Jun 2017
(AR aberrant)
rymsdvlgly(dfgzvbhyqt) = gokxfqwyfm znjzlyfiod (tdrmutgifb )
Not Applicable
-
niqxlmieus(yylfhigbrg) = The combination therapy significantly increased G1/S arrest kqjuggilny (oswnubvryv )
-
01 Jun 2016
Phase 1/2
90
ER ONA tablets 10-50 mg BID
xgyhicdlwc(qoohyijbgw) = azcatpvsts qiyrqqulog (uzrhmrrvel )
-
20 May 2015
100 mg immediate release QD
xgyhicdlwc(qoohyijbgw) = jufjaoxyfl qiyrqqulog (uzrhmrrvel )
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Regulation

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