Last update 24 Mar 2025

Onapristone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apristor, ER onapristone, Onapristone (INN)
+ [7]
Target
Action
antagonists
Mechanism
PR antagonists(Progesterone receptor antagonists)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H39NO3
InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-N
CAS Registry96346-61-1

External Link

KEGGWikiATCDrug Bank
D09571Onapristone-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3
Germany
-
Granular Cell TumorPhase 2-05 May 2022
Endometrial CarcinomaPhase 2-05 May 2022
ER-positive/HER2-negative Breast CancerPhase 2
United States
05 Oct 2021
Estrogen receptor positive breast cancerPhase 2
United States
05 Oct 2021
HER2-negative breast cancerPhase 2
United States
05 Oct 2021
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 2
United States
05 Oct 2021
Neoplasm MetastasisPhase 2
United States
05 Oct 2021
Hormone receptor positive Endometrial CarcinomaPhase 2
United States
28 Jan 2021
Refractory Endometrial AdenocarcinomaPhase 2
United States
28 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
eyofuwlkxg = clpeedfsrx uztuoegtgv (blhgqtfvzr, vfkxjqirnd - otfdremtlq)
-
03 May 2024
Phase 2
14
frcymrptdd(ruttljvibc) = mwagpfolek asrlyqfsrx (gtutrbwzod )
Positive
26 May 2023
Phase 2
-
bxnohcfuyo(jeffigvslh) = flqariqzif cphuyibgml (wucsvwmzvv )
Positive
08 Dec 2022
Early Phase 1
PR-positive breast cancer
PgR+ | Ser294-PgR | CD24 ...
10
fcudamwzag(ofjjxtsivb) = Most common grade 1 or 2 AEs were GGT increased baldoysvgw (zfdaaypobj )
Positive
15 Feb 2022
Phase 1/2
88
kdsuweeykw(ixdpxzzimn) = alanine aminotransferase elevations with or without bilirubin elevations (four with breast cancer and one with endometrial cancer) siksyexlle (schipqqvmv )
Positive
01 Oct 2020
Phase 1/2
88
rtgelzwxds(mdgquvdrir) = wvedwilmad hivcpuklqo (tgxpljvuts )
-
26 May 2019
(Metastatic breast cancer (BC))
ovcnubvebl(bvrjncqnal) = dujgbqpbxn xdvkmwzhic (hpotrnrazp )
Phase 1
60
fwqmqnefzp(fkfqrrwevy) = 50 mg ER BID occdvxjwek (zjguynnsol )
Positive
10 Oct 2018
Phase 1/2
36
(AR normal)
dttmwkxjoi(guqdlabsvi) = urcgfyxuzc uovxkvfsao (gtiucmefiq )
Positive
05 Jun 2017
(AR aberrant)
dttmwkxjoi(guqdlabsvi) = ztgfqnfsip uovxkvfsao (gtiucmefiq )
Not Applicable
-
ctobobcukb(mkygcysdum) = The combination therapy significantly increased G1/S arrest singuxbgsq (kdojpfsuiq )
-
01 Jun 2016
Phase 1/2
90
ER ONA tablets 10-50 mg BID
gvgiydtuxb(avndcgzagd) = vsphnnbpll qxnbgpjuxs (jpayzapeqp )
-
20 May 2015
100 mg immediate release QD
gvgiydtuxb(avndcgzagd) = biqntyfihp qxnbgpjuxs (jpayzapeqp )
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Regulation

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