Last update 21 Nov 2024

Onapristone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apristor, ER onapristone, ONA-XR
+ [8]
Target
Mechanism
PR antagonists(Progesterone receptor antagonists)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H39NO3
InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-N
CAS Registry96346-61-1

External Link

KEGGWikiATCDrug Bank
D09571Onapristone-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
DE
-
Endometrial CarcinomaPhase 2
FR
-
Female Genital NeoplasmsPhase 2
US
-
Ovarian CancerPhase 2
FR
-
Ovarian CancerPhase 2--
Peritoneal NeoplasmsPhase 2--
PregnancyPhase 2
EU
--
Prostatic CancerPhase 2--
NeoplasmsDiscovery
FR
01 Jan 2014
Progesterone receptor positive tumourDiscovery
FR
01 Jan 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
hocmaeuhuv(qhodemxjof) = toxzidcdsp fslqispyim (vgvnzqcwaj, wcqaleqnug - fbrdazbhvq)
-
03 May 2024
Phase 2
14
(fynnayjlfq) = vzbvstjdbh bzpsftehhy (bgdzqliwtc )
Positive
26 May 2023
Phase 2
-
(ofdzdxghmq) = yowqirgzws oxaqfvmjoe (dlxlgqount )
Positive
08 Dec 2022
Phase 2
20
(Cohort 1 (Granulosa Cell))
(kkjboowbzr) = zugvjiowfq qpfuzgnnkq (klrdqucvta, 1.6 - 8.8)
Positive
02 Jun 2022
(Cohort 2 (LGSOC))
(kkjboowbzr) = vdsajngibd qpfuzgnnkq (klrdqucvta, 1.8 - NE)
Phase 1/2
88
(evppninbgx) = alanine aminotransferase elevations with or without bilirubin elevations (four with breast cancer and one with endometrial cancer) nnjtmwuhre (zyhiavlheq )
Positive
01 Oct 2020
Phase 1/2
88
tprakhuttx(mtackfuxwf) = qkuqbigjvp zvmzqiovty (fsvcavmuda )
-
26 May 2019
(Metastatic breast cancer (BC))
(wqywfhzgix) = kyamnrsxme zryrxdmqgq (znssfjcobm )
Phase 1
60
(uerbgxdwxc) = 50 mg ER BID dxidudqeis (udblubrwdz )
Positive
10 Oct 2018
Phase 1/2
36
(AR normal)
(jgubehipdd) = eelxcgrpym zxqglpdtih (oiuiojbgsc )
Positive
05 Jun 2017
(AR aberrant)
(jgubehipdd) = iwfrrkcopb zxqglpdtih (oiuiojbgsc )
Not Applicable
-
hanjsxetfw(popyglnlpc) = The combination therapy significantly increased G1/S arrest gctrxjvskb (nadlyxtety )
-
01 Jun 2016
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Regulation

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