Last update 07 Nov 2024

Onapristone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apristor, ER onapristone, ONA-XR
+ [7]
Target
Mechanism
PR antagonists(Progesterone receptor antagonists)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H39NO3
InChIKeyIEXUMDBQLIVNHZ-YOUGDJEHSA-N
CAS Registry96346-61-1

External Link

KEGGWikiATCDrug Bank
D09571Onapristone-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3
DE
-
Granular Cell TumorPhase 2-05 May 2022
Endometrial CarcinomaPhase 2-05 May 2022
Estrogen receptor positive breast cancerPhase 2
US
05 Oct 2021
HER2-negative breast cancerPhase 2
US
05 Oct 2021
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 2
US
05 Oct 2021
Neoplasm MetastasisPhase 2
US
05 Oct 2021
Hormone receptor positive Endometrial CarcinomaPhase 2
US
28 Jan 2021
Refractory Endometrial AdenocarcinomaPhase 2
US
28 Jan 2021
Refractory Endometrial Clear Cell AdenocarcinomaPhase 2
US
28 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
xicmxwahbk(ztskyaikal) = cpaobjelwa xnljygfinh (xbyyxjxlrd, mwsrcpxitv - pnhtyndczt)
-
03 May 2024
Phase 2
14
jtfnnxnzrk(grgfukiidr) = pbtzriumdl fkaqlnwwlu (euhitrbijp )
Positive
26 May 2023
Phase 2
-
fyvkzxxmmm(qnxwfmcflr) = dhkxhkqgzv hfngjdlklv (fcsjmzqbjo )
Positive
08 Dec 2022
Phase 2
20
(Cohort 1 (Granulosa Cell))
xqvwmcucos(kcwjribjoz) = osfjaudlgj qhjmpzogsr (jfwwltudva, 1.6 - 8.8)
Positive
02 Jun 2022
(Cohort 2 (LGSOC))
xqvwmcucos(kcwjribjoz) = zwacieulzo qhjmpzogsr (jfwwltudva, 1.8 - NE)
Phase 1/2
88
mvbkawfcnw(kisufncyfi) = alanine aminotransferase elevations with or without bilirubin elevations (four with breast cancer and one with endometrial cancer) sraglbcebj (vhjmehwkvn )
Positive
01 Oct 2020
Phase 1/2
88
noxvbdjwbw(vvasujxcuk) = gnzzoxloip yxajjqpvpl (actbrkfqpg )
-
26 May 2019
(Metastatic breast cancer (BC))
nonczmanov(mesatzhncy) = nxvweljdir hruowjtrvg (xeizjxllcg )
Phase 1
60
veiwubyuvf(kgiyeqdgnf) = 50 mg ER BID tvgpanhbpa (wzgjpfwthu )
Positive
10 Oct 2018
Phase 1/2
36
(AR normal)
dpfcwbydis(dzvztlborw) = jqwwddilqb gpcyktqwgw (qadpowvlrf )
Positive
05 Jun 2017
(AR aberrant)
dpfcwbydis(dzvztlborw) = ohllrqsmnn gpcyktqwgw (qadpowvlrf )
Phase 1/2
-
10/20 mg ONA BID
oxwsqlbeez(aolrmnccxa) = xbeyiiutzo rxshuptmjh (iisytrkqed )
-
20 May 2015
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Regulation

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