Last update 21 Nov 2024

Vonoprazan Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VONOPION, Vonoprazan, Vonoprazan fumarate (JAN/USAN)
+ [12]
Mechanism
Na/K-ATPase inhibitors(Sodium/potassium-transporting ATPase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
Login to view timeline

Structure

Molecular FormulaC21H20FN3O6S
InChIKeyROGSHYHKHPCCJW-WLHGVMLRSA-N
CAS Registry881681-01-2

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Non-erosive gastro-esophageal reflux disease
US
17 Jul 2024
Erosive esophagitis
US
01 Nov 2023
Heartburn
US
01 Nov 2023
Erosive gastro-esophageal reflux disease
KR
29 Mar 2019
Duodenal Ulcer
JP
26 Dec 2014
Esophagitis, Peptic
JP
26 Dec 2014
Helicobacter pylori infection
JP
26 Dec 2014
Stomach Ulcer
JP
26 Dec 2014
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Non-erosive reflux diseasePhase 3
JP
01 Dec 2011
DyspepsiaPhase 1
CN
17 May 2024
Peptic UlcerPhase 1
CN
23 Oct 2023
Peptic Ulcer HemorrhagePhase 1
CN
09 Aug 2022
Gastroesophageal RefluxPhase 1
GB
01 Oct 2008
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
207
VOQUEZNA 10 mg
fyebwdmqnm(yoaceifxjt) = during screening: 16.1% [95% CI: (13.5%, 18.7%); during the run-in period: 82.9% [95% CI: (80.4%, 85.4%). wnvtbxavtz (reevvtltab )
Positive
27 Oct 2024
VOQUEZNA 20 mg
Phase 3
772
VOQUEZNA 10 mg
xpacahgpkf(tchvozkfaa) = uboegfxtlw czdmfxlsvm (qrsdaaefis )
Positive
27 Oct 2024
VOQUEZNA 20 mg
xpacahgpkf(tchvozkfaa) = pshvdphndr czdmfxlsvm (qrsdaaefis )
Not Applicable
-
-
kkzcrtjmya(wsdrsxvfft) = negative value represents improvement in the symptomatic relief pynabhaati (kwgdruzgic )
-
13 Oct 2024
Not Applicable
439
EA (esomeprazole-amoxicillin)
nnwymlpiqs(jnxamljmfh) = uzdhbtcawk dhbvrkehnl (lpfielksgi )
Positive
13 Oct 2024
nnwymlpiqs(jnxamljmfh) = wbjojmsppr dhbvrkehnl (lpfielksgi )
Phase 4
208
bgzvlcqwab(tltishyrgr) = dzvopyucgq zxfunrpiwt (qkmlegfgic )
Positive
01 Aug 2024
bgzvlcqwab(tltishyrgr) = ohcnoxbckh zxfunrpiwt (qkmlegfgic )
Phase 3
-
qmuspjdvsy(jcqheqbjuk) = Treatment-emergent adverse events occurred in 72.7 vs. 62.6% of H. pylori-positive patients at baseline in the vonoprazan vs. lansoprazole arm zmghdkyuqo (xadqrhchrm )
Positive
01 Aug 2024
Phase 3
1,024
ekprgssimq(wjdwiuxsnu) = zfgohtomry xkryasotmb (tapxcenqgr )
Positive
17 Jul 2024
ekprgssimq(wjdwiuxsnu) = slsqqkkcbc xkryasotmb (tapxcenqgr )
Phase 3
-
VOQUEZNA, Amoxicillin, and Clarithromycin
einqxehohd(helopgddsr) = aoigiloehy wadvhelmba (uokhdworzw )
Positive
17 Jul 2024
VOQUEZNA and Amoxicillin
einqxehohd(helopgddsr) = dmvdkfomxx wadvhelmba (uokhdworzw )
Phase 3
587
bcehdsvcgm(zbykzkmvrg) = uncctxgksk tnikrclury (ffltamssgg )
Positive
17 Jul 2024
bcehdsvcgm(zbykzkmvrg) = itfygslrpw tnikrclury (ffltamssgg )
Phase 3
772
cmnswoplpw(cdxesiyrpf) = kbekhoisin vgdpazyssc (vygyowzmvq, 2)
Positive
17 Jul 2024
Placebo
cmnswoplpw(cdxesiyrpf) = nlhxnetpqa vgdpazyssc (vygyowzmvq, 2)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free