Delving into the Latest Updates on Hydroxyproline with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(2S,4R)-4-Hydroxyproline, (2S,4R)-4-羟脯氨酸, L-hydroxyproline

Target-

Mechanism-

Therapeutic Areas

Congenital DisordersEndocrinology and Metabolic DiseaseUrogenital Diseases+ [1]

Active Indication-

Inactive Indication

Hyperoxaluria, PrimaryNephrocalcinosisNephrolithiasis, Calcium Oxalate

Originator Organization-

Active Organization-

Inactive Organization

National Institutes of Health

Drug Highest PhasePendingPhase 1/2

First Approval Date-

Regulation-

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Primary hyperoxaluria is an inborn error of metabolism that results in marked overproduction of oxalate by the liver. The excess oxalate causes kidney failure and can cause severe systemic disease due to oxalate deposition in multiple body tissues.
Metabolic pathways that lead to oxalate are poorly understood, but recent evidence suggests that hydroxyproline may play a role. Sources of hydroxyproline include the diet and bone turnover. If hydroxyproline can be confirmed as a significant factor in primary hyperoxaluria, diet modification might be of value in reducing the severity of disease.
This protocol, in which hydroxyproline labelled with a cold isotope is infused intravenously in patients with primary hyperoxaluria, will allow the researchers to measure the amount of oxalate produced from hydroxyproline. The contribution of hydroxyproline metabolism to the amount of oxalate excreted in urine in will be able to be determined for patients with each of the known types of primary hyperoxaluria.

Start Date01 Sep 2013

Sponsor / Collaborator

Mayo Clinic

[+2]

100 Clinical Results associated with Hydroxyproline

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100 Translational Medicine associated with Hydroxyproline

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100 Patents (Medical) associated with Hydroxyproline

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69

Literatures (Medical) associated with Hydroxyproline

01 Mar 2025·Food Chemistry

Long-term feeding of high plant-based diets supplemented with additive mixtures improves the fillet quality of rainbow trout, Oncorhynchus mykiss

Article

Author: Chen, Da ; Singha, Krishna Pada ; Kumar, Vikas

Although more sustainable, feeding fish solely plant protein (PP) deteriorates their fillet quality more than animal counterparts, which additives can alleviate. This study investigated the effects of supplementing high PP diets with two additive mixtures on the fillet quality of rainbow trout (Oncorhynchus mykiss). Fish (∼2.2g) were fed with four isonitrogenous (42 % CP) and isolipidic (20 % lipid) diets: fishmeal-based (FM), plant-based (PP), PP + A1 (PP with a mixture of krill meal, taurine, and organic selenium) and PP + A2 (PP with a mixture of proline, hydroxyproline, and vitamin C) diets, for seven months. Different diets significantly (p < 0.05) affected fatty acid composition, textural profile, hydroxyproline and collagen content, and genes related to collagen synthesis. The short-term (ice vs. -20 °C) and long-term (-20 °C, 90 days) storage conditions showed significant (p < 0.05) effects on different fillet quality attributes, including protein secondary structures. Overall, supplementing additive mixtures improved the fresh and stored fillet quality.

01 Sep 2016·PainQ1 · MEDICINE

Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

Q1 · MEDICINE

Article

Author: Price, Theodore J ; Schmidt, Robert E ; Vogt, Sherri K ; Davidson, Steve ; Valtcheva, Manouela V ; Golden, Judith P ; Ray, Pradipta R ; Gereau, Robert W ; Copits, Bryan A ; Ghetti, Andrea

AbstractWe introduce a strategy for preclinical research wherein promising targets for analgesia are tested in rodent and subsequently validated in human sensory neurons. We evaluate group II metabotropic glutamate receptors, the activation of which is efficacious in rodent models of pain. Immunohistochemical analysis showed positive immunoreactivity for mGlu2 in rodent dorsal root ganglia (DRG), peripheral fibers in skin, and central labeling in the spinal dorsal horn. We also found mGlu2-positive immunoreactivity in human neonatal and adult DRG. RNA-seq analysis of mouse and human DRG revealed a comparative expression profile between species for group II mGluRs and for opioid receptors. In rodent sensory neurons under basal conditions, activation of group II mGluRs with a selective group II agonist produced no changes to membrane excitability. However, membrane hyperexcitability in sensory neurons exposed to the inflammatory mediator prostaglandin E2 (PGE2) was prevented by (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC). In human sensory neurons from donors without a history of chronic pain, we show that PGE2 produced hyperexcitability that was similarly blocked by group II mGluR activation. These results reveal a mechanism for peripheral analgesia likely shared by mice and humans and demonstrate a translational research strategy to improve preclinical validation of novel analgesics using cultured human sensory neurons.

01 Sep 2015·Journal of Dermatological ScienceQ2 · MEDICINE

(2R/S,4R)-2-(2,4-Dihydroxyphenyl)thiazolidine-4-carboxylic acid prevents UV-induced wrinkle formation through inhibiting NF-κB-mediated inflammation

Q2 · MEDICINE

Letter

Author: Han, Yu Kyeong ; Lee, Eun Kyeong ; Ha, Young Mi ; Lee, Bonggi ; An, Hye Jin ; Moon, Hyung Ryong ; Kim, Dae Hyun ; Chung, Hae Young ; Chun, Pusoon ; Chung, Ki Wung ; Son, Sujin ; Yun, Hwi Young ; Moon, Kyoung Mi ; Ullah, Sultan

This study examined inhibitory effects of (2R/S,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid on wrinkle formation using Hs27 human dermal fibroblasts and HR-1 hairless mouse.In this study Hs27 human dermal fibroblasts were pretreated with MHY384 followed by UVA exposure and type 1 procollagen concentration in culture medium was measured using an ELISA kit.This study resulted that, (2R/S,4R)-2-(2,4-Dihydroxyphenyl)thiazolidine-4-carboxylic acid prevented UV-induced wrinkle formation through inhibiting NF-κB-mediated inflammation using Hs27 human dermal fibroblasts and HR-1 hairless mouse.This study concluded that MHY384 could be potentially used to prevent wrinkle formation and would be a novel additive for anti-aging cosmetics.

100 Deals associated with Hydroxyproline

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Hydroxyproline	-	DB08847

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hyperoxaluria, Primary	Phase 2	US	National Institutes of Health	30 Sep 2013
Nephrocalcinosis	Phase 2	US	National Institutes of Health	30 Sep 2013
Nephrolithiasis, Calcium Oxalate	Phase 2	US	National Institutes of Health	30 Sep 2013

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2014	Not Applicable	Hyperoxaluria	-	Hydroxyproline (Patients with PH type 1)	(fthguuwhwp) = bzhokwdhzq hadejtqfjs (wkvlytyyvj, 11) View more	Positive	11 Nov 2014
ASN2012	Not Applicable	-	4	Hydroxyproline (Normal Subjects)	wbivvsrkqn(krsulfiobj) = omwphpaqle xylajbpzih (qayiblcmeb, 3.7) View more	-	30 Oct 2012