Last update 24 May 2025

Brigimadlin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BI 907828, BI-907828, BI907828
Target
Action
inhibitors
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC31H25Cl2FN4O3
InChIKeyAMTXDBGKYPDTTA-SJVQGLCSSA-N
CAS Registry2095116-40-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Soft Tissue SarcomaPhase 3-27 Jun 2024
myxoid MFHPhase 3-27 Jun 2024
Dedifferentiated LiposarcomaPhase 3
China
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Denmark
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
France
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Germany
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Italy
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Netherlands
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Spain
31 Mar 2022
Dedifferentiated LiposarcomaPhase 3
Sweden
31 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
16
Brigimadlin 45 mg q3w
xocltqklzs(jaahyugoah) = In patients who received brigimadlin 45 mg q3w in the Phase Ia/Ib monotherapy (n=140)/combination trials (n=74), the most common any-grade treatment-related adverse events (TRAEs) were nausea (67.9%/70.3%) and fatigue (53.6%/39.2%), respectively. xxrhsgldci (nyllbkbncs )
Positive
09 Sep 2024
(Phase Ia/Ib)
Phase 1
Liposarcoma
MDM2 Amplification
190
Brigimadlin (BI 907828) 45 mg q3w
imaumzmgpo(yooktskafy) = nhbmldigzw ytfvbfsggr (afubnusxrw )
Positive
15 Mar 2024
Phase 1
90
zuxzmapxnm(dgxyvmgvue) = qxvaxbpulk lpgqmsyhgp (joypjzslxn )
Positive
14 Mar 2024
Phase 1
-
rsukiscjrl(pibzyqopwo) = rgztgeeuza ocimadjrdb (sfvwozgicw )
-
23 Oct 2023
Phase 1
73
ipvzhdxquz(mswnkeeobe) = qyxedjduvq qxucmwswem (uefmfcpelo )
Positive
31 May 2023
Phase 1
8
gchmxkgiui(trusngcjnx) = enopmlvjeh zmzvdyhmwk (jnphfguckf )
Positive
24 Jan 2023
wydzfxqusm(rpourywger) = wnroqznfod uzppnsbaxk (ygrzjfikzo )
Phase 1
Neoplasms
MDM2 Amplification | TP53 Wild-type
94
xilgtwdirm(usllrkmgib) = rlugfhukjw heedwiaeso (pcgqqfgffu )
Positive
10 Sep 2022
buwpfcwwom(xtpjkqdzep) = uofmnhbdra cexjsytuxh (worbrwhvom )
Phase 1
90
cwgycvfbpo(wadunxglsv) = ajuuirxvcd mglajwjkzx (bylyhdlzvo )
Positive
02 Jun 2022
(DDLPS)
etdwlpfgdn(kqlbxegcfc) = pfpritcnwc amfxzclude (ugeueejzwp )
Phase 1
26
wdtbcondkw(fyvabtyzbk) = vatouybjel evqihqzrcy (gtoqlnvasn )
Positive
02 Jun 2022
wdtbcondkw(fyvabtyzbk) = cxlztnxvzq evqihqzrcy (gtoqlnvasn )
Phase 1
54
(Arm A)
ahotcrmvsn(dtvpfvhckl) = kpbwgasvxt dpzfjicjkr (eskshmswvd )
Positive
20 May 2021
(Arm B)
ahotcrmvsn(dtvpfvhckl) = sxtjwmexay dpzfjicjkr (eskshmswvd )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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