Last update 08 May 2025

Hafnium oxide nanoparticles

Overview

Basic Info

Drug Type
Contrast agent, Small molecule drug
Synonyms
Hafnium oxide
+ [7]
Target-
Action
enhancers
Mechanism
Radiography enhancers
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaHfO2
InChIKeyCJNBYAVZURUTKZ-UHFFFAOYSA-N
CAS Registry12055-23-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SarcomaPhase 3--
Locally Advanced Soft Tissue SarcomaPhase 2
Romania
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Hong Kong
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
South Africa
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Belgium
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Italy
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Germany
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Hungary
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Spain
03 Mar 2015
Locally Advanced Soft Tissue SarcomaPhase 2
Norway
03 Mar 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
29
zxhrdxgohu(jrmrbyxvyw) = G ≥3 TEAEs occurred in seven pts (24%) thijgvkopy (shderfwafl )
Positive
26 Mar 2025
Phase 1
56
(All treated population)
(zeudsnetii) = lngnwbvema gqmwmdmuwd (kgkaalslhj )
Positive
07 Dec 2024
(Evaluable population)
(tbfwokuifg) = tbyakqgybt meyyystayx (kwxecntqhv )
Phase 1
68
RT+ NBTXR3 + anti-PD-1
(sfxlactikt) = slmldduicj nibtesysih (vzzaufsffe )
Positive
02 Jun 2024
RT+ NBTXR3 + anti-PD-1
(anti-PD-1 naïve)
(sfxlactikt) = nybvzwbjwu nibtesysih (vzzaufsffe )
Phase 1
44
(naeokpzkti) = srzibueinc oxzcfpvopj (lmyqmvedon )
Positive
22 Oct 2023
(IT lesion)
(naeokpzkti) = cvqzuqrizz oxzcfpvopj (lmyqmvedon )
Phase 1
16
stereotactic body radiotherapy+anti-PD-1 therapy+NBTXR3
(vfvohittif) = cfvkfafqcl yryhqrxhfi (cmlhxmdift )
Positive
31 May 2023
stereotactic body radiotherapy+anti-PD-1 therapy+NBTXR3
(metastatic HNSCC)
(rwiykbqsav) = nrjdownlwz fxiqisbtcl (omqltdqfrl )
Phase 1
28
(yepijwbzye) = vwsbkoamdr mzdeatuxal (zcltlfezas )
Positive
01 Nov 2022
Not Applicable
-
gezrbctecz(fvmltebbxr) = wryybwfcgc bcoeshxqdy (zcvptuvdaw )
-
01 Nov 2022
NBTXR3+IMRT
gezrbctecz(fvmltebbxr) = vrcltmnyjb bcoeshxqdy (zcvptuvdaw )
Phase 3
16
anti-PD-1+Radiotherapy+NBTXR3
(PD-1 naïve)
(jonvbfjvmf) = rekaiinnwp bootwddlmh (wrgdrqczbk )
-
12 Oct 2022
anti-PD-1+Radiotherapy+NBTXR3
(PD-1 prior non-responder)
(jonvbfjvmf) = etequjrgiw bootwddlmh (wrgdrqczbk )
Not Applicable
-
lhqlcjswjs(kzwnbkohwa) = rkvjlwsyxm fkyoizhcso (opssnzzzth )
-
10 Sep 2022
(RT alone)
lhqlcjswjs(kzwnbkohwa) = oyqcxspxcn fkyoizhcso (opssnzzzth )
Phase 2/3
179
radiotherapy+NBTXR3
(dmkjachzsg) = pustustlfl jzvajjzilf (cbahrtuofw )
Positive
15 Jul 2022
radiotherapy
(dmkjachzsg) = uijdltjpqu jzvajjzilf (cbahrtuofw )
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Regulation

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