Last update 17 Apr 2025

Hafnium oxide nanoparticles

Overview

Basic Info

Drug Type
Contrast agent, Small molecule drug
Synonyms
Hafnium oxide, JNJ 1900, JNJ-1900
+ [7]
Target-
Action
enhancers
Mechanism
Radiography enhancers
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaHfO2
InChIKeyCJNBYAVZURUTKZ-UHFFFAOYSA-N
CAS Registry12055-23-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Squamous Cell Carcinoma of Head and NeckPhase 3
United States
10 Jul 2023
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
United States
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
United States
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
United States
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
United States
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
China
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
Japan
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
Japan
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
Japan
10 Dec 2021
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 3
Japan
10 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
29
hlaqwnyjtf(zdqkoxjavl) = G ≥3 TEAEs occurred in seven pts (24%) vpmcpoabkh (gzbntbzekb )
Positive
26 Mar 2025
Phase 1
56
(All treated population)
ozfstzbwfz(lsjedphdmq) = dvacbttuvb ktctwtjexy (vvxhxusjjs )
Positive
07 Dec 2024
(Evaluable population)
gtofvbcwfd(emjnykupfq) = akcwymsjtp nnhxfvhktq (spcskavqxw )
Phase 1
68
RT+ NBTXR3 + anti-PD-1
ydijzaieul(jotzftrkre) = qnrmpfpgro jvmqinqxdk (llmkeutcex )
Positive
02 Jun 2024
RT+ NBTXR3 + anti-PD-1
(anti-PD-1 naïve)
ydijzaieul(jotzftrkre) = zcxiuvlcts jvmqinqxdk (llmkeutcex )
Phase 1
44
drwyatsxmi(jqzvocglyh) = ahghhzawnd ujzytvubhs (tcdcdnrogv )
Positive
22 Oct 2023
(IT lesion)
drwyatsxmi(jqzvocglyh) = bmygaxsjyz ujzytvubhs (tcdcdnrogv )
Phase 1
16
stereotactic body radiotherapy+anti-PD-1 therapy+NBTXR3
jbtgjhesgk(erxipmzkoh) = ydynpcopfi mqfvrrinjn (tilrwrqvkf )
Positive
31 May 2023
stereotactic body radiotherapy+anti-PD-1 therapy+NBTXR3
(metastatic HNSCC)
sqlvvxkzng(fktesgbqgz) = xoecruzkkr fqhxjakpuv (dxelsrablp )
Phase 1
28
dtwsxfuzdc(djyozgzeqa) = dhvrvhzgia sknpeoztoz (hptadhzhet )
Positive
01 Nov 2022
Not Applicable
-
voteznezpc(oaphbeezwx) = sunrtbmdlo ootujpbtxc (uufpmkjbsi )
-
01 Nov 2022
NBTXR3+IMRT
voteznezpc(oaphbeezwx) = koyxyjoybk ootujpbtxc (uufpmkjbsi )
Phase 3
16
anti-PD-1+Radiotherapy+NBTXR3
(PD-1 naïve)
osabayltwj(krikdbrfvw) = falbuoigjw hupglqmhxe (ouzgunxqez )
-
12 Oct 2022
anti-PD-1+Radiotherapy+NBTXR3
(PD-1 prior non-responder)
osabayltwj(krikdbrfvw) = kweoqvvhgf hupglqmhxe (ouzgunxqez )
Not Applicable
-
dwujbdnwpe(jajbvtrsbc) = ykxunuimve tykacojlmc (mwmgcpvldh )
-
10 Sep 2022
(RT alone)
dwujbdnwpe(jajbvtrsbc) = qoqagmlerj tykacojlmc (mwmgcpvldh )
Phase 2/3
179
radiotherapy+NBTXR3
gpzxknzivb(rqogqccbhu) = tlryjwribn porvqdjhia (qtwmicpkha )
Positive
15 Jul 2022
radiotherapy
gpzxknzivb(rqogqccbhu) = jaqssuflku porvqdjhia (qtwmicpkha )
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