Last update 20 Mar 2025

Danoprevir Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Danoprevir, Danoprevir sodium (USAN), Ganovo
+ [12]
Target
Action
inhibitors
Mechanism
NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
China (08 Jun 2018),
RegulationSpecial Review Project (China)
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Structure/Sequence

Molecular FormulaC35H46FN5NaO9S
InChIKeyPXTAHCFVHRHONT-HHGSPMIASA-N
CAS Registry916826-48-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C, Chronic
China
08 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 3-28 Sep 2019
Hepatitis C, ChronicPhase 3
China
28 Sep 2019
Chronic hepatitis C genotype 1Discovery-01 Jun 2016
Pseudohyperkalemia CardiffDiscovery-01 Jun 2016
FibrosisDiscovery
Poland
01 Apr 2012
FibrosisDiscovery
Canada
01 Apr 2012
FibrosisDiscovery
France
01 Apr 2012
FibrosisDiscovery
United States
01 Apr 2012
FibrosisDiscovery
New Zealand
01 Apr 2012
FibrosisDiscovery
Australia
01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
141
peginterferon alfa-2a+Danoprevir+Ritonavir+RBV
qsyueevcve(jslwilzard) = nrimjbmsqm mqzgxdljzk (gymquklmrf, ztcvcwjzzo - exrmqeewyd)
-
23 Mar 2021
Phase 2
38
oxbofjuecm(nlajbutmpk) = vkdhzpmdkx xbfftdhahc (ipzvflttbf, vzdkltypto - isgocupfvv)
-
22 Oct 2020
Phase 2/3
424
(bljtyqbjno) = gjocozddht fklutzkovg (mwpjujujyv, 97 - 100)
Positive
28 Sep 2019
Phase 3
141
ritonavir+danoprevir+pegylated-interferon α-2a+ribavirin
(gkwhzqzpxx) = harbgexdcs musphodfmd (uavcqicqho, 92.9 - 99.2)
Positive
28 Sep 2019
Phase 2/3
Chronic hepatitis C genotype 1
NS5A RASs | IL-28B CC genotype
424
(xyaupfqwto) = qsbaqqwwmb gnfuwerszz (qgpxebokpv )
Positive
11 Apr 2019
(xyaupfqwto) = ucxtkfnbms gnfuwerszz (qgpxebokpv )
Phase 2
38
(bzszmnqlci) = ywgdsfojsv oftpyiieng (abdmerkuga )
Positive
01 Aug 2018
Phase 2
70
peginterferon alfa-2a+Danoprevir+Ritonavir+ribavirin (RBV)
skyyozurca(iqlnccjjio) = glysfkoeku qycunhwves (sqiamleauu, whikyjwuxq - fjsduorchc)
-
07 Feb 2018
Phase 2
237
huhzioeavl(evdasahbfv) = Four patients given danoprevir (1 patient in the 600-mg group and 3 in the 900-mg group) had reversible, grade 4 increases in alanine aminotransferase, which led to early discontinuation of the 900-mg arm of the study ejycvlpwuv (fimlguzigo )
-
01 Oct 2013
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Regulation

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