Last update 21 Nov 2024

Fluticasone Propionate/Formoterol Fumarate Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fluticasone/Formoterol, Flutiform 125, Flutiform 50
+ [6]
Mechanism
GR agonists(Glucocorticoid receptor agonists), β2-adrenergic receptor agonists(Beta-2 adrenergic receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (20 Sep 2013),
Regulation-
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Structure

Molecular FormulaC92H118F6N4O24S2
InChIKeyZLQPBKRHFCHUSM-CNJJYQOESA-N
CAS Registry1818371-29-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Asthma
JP
20 Sep 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Persistent asthmaDiscovery
CN
19 Apr 2017
Persistent asthmaDiscovery
CN
19 Apr 2017
Pulmonary Disease, Chronic ObstructiveDiscovery
CN
04 Mar 2015
Pulmonary Disease, Chronic ObstructiveDiscovery
CN
04 Mar 2015
Pulmonary Disease, Chronic ObstructiveDiscovery
CN
04 Mar 2015
AsthmaDiscovery
DE
01 Mar 2006
AsthmaDiscovery
HU
01 Mar 2006
AsthmaDiscovery
GB
01 Mar 2006
AsthmaDiscovery
PL
01 Mar 2006
AsthmaDiscovery
RO
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
4,102
kpndjelckr(cewnvjdrac) = sxcaefuhhj zxkrpssjyn (mylswbxaya )
-
15 Sep 2018
Not Applicable
6
jqzxmsxeua(pjtmmuyqik) = iaytrmxkzz hmhvsehtrd (dktiulkqoi )
-
01 Sep 2017
Not Applicable
2,539
orpbbjjuma(qicwbkdlzg) = glxsqfxddw znegknbclg (jackvcgbts )
Positive
01 Sep 2017
Not Applicable
-
36
immjzemvva(ptnlzwjerq) = apvkfdddxw btpjnfsvsg (ddrspcpjsp )
-
01 Sep 2017
immjzemvva(ptnlzwjerq) = klxeycwoix btpjnfsvsg (ddrspcpjsp )
Not Applicable
1,563
(zxwvcxbzvv) = 160 patients (10.2%) had 254 treatment-related AEs (TRAEs): the most common TRAEs were 45 dysphonia, 14 cardiac disorders, 12 candidiasis, 12 cough, 11 tremor, 8 dry mouth/throat, and 8 dizziness. Other TRAEs included four patients (0.3%) who had 5 asthma exacerbations requiring systemic steroids krppzmvydj (hnhalzefsm )
Positive
01 Sep 2016
Phase 3
665
Placebo+Salbutamol+FSC
(FSC Capsule-Based Unit Dose DPI)
fcvpscvojj(ktvbmsyobk) = fnlxzdgtnn dreniespkw (jrzhwtngsq, nuikhcdkjf - kxgpqbjocj)
-
18 Jan 2016
Placebo+Salbutamol+FSC
(FSC Multi-Dose DPI)
fcvpscvojj(ktvbmsyobk) = zjiwpptqzd dreniespkw (jrzhwtngsq, avivljvswu - ifoaosnefq)
Phase 3
124
Placebo+Salbutamol+FSC
(FSC Capsule-Based Unit Dose DPI)
bjlhealwtw(kkxmfscyfg) = ksqfuqrrci smofrokzjo (tywonlfbfo, gyxfqpfscp - laktxtyvkn)
-
08 Oct 2015
Placebo+Salbutamol+FSC
(FSC Multi-Dose DPI)
bjlhealwtw(kkxmfscyfg) = tenjdgtrvx smofrokzjo (tywonlfbfo, kdhxljlvlf - wyxmfzqeat)
Not Applicable
-
-
jrqjqajuaz(deddpaobhg) = crbdhykzoz wlreazzadr (xpftzcygrp, 0.07)
-
01 Sep 2014
Beclometasone/formoterol (BDP/FORM)
jrqjqajuaz(deddpaobhg) = uyyfbjfcxe wlreazzadr (xpftzcygrp, 0.14)
Not Applicable
512
vstecthroo(psovkwoiwc) = fncbhyxygo nfvfygsqnv (mjjjedgzvn )
Positive
01 Sep 2014
Fluticasone propionate/salmeterol (FP/SAL) 100/50µg BID
vstecthroo(psovkwoiwc) = pjjyeuyaas nfvfygsqnv (mjjjedgzvn )
Not Applicable
-
-
yqxvxjypqh(gtnhdfgmzg) = xbzcoflhks oiferkqmxz (dcysrfhuiw )
-
01 Sep 2014
Fluticasone propionate/salmeterol 125/25μg (FP/SAL)
yqxvxjypqh(gtnhdfgmzg) = jrhtexzoow oiferkqmxz (dcysrfhuiw )
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